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Beginning-to-end Solutions for Cell Culture, Bioprocess, and Drug Discovery

Since the introduction of our first products almost 100 years ago, laboratory professionals have come to rely on the Corning brand for quality products with features that make it easier to get work done. Whether cell culture, bioprocess, or drug discovery, the Corning brand delivers innovative vessels, advanced surfaces, and quality media that help you get it right from the start.

Organoid Counting Software for the Corning® Cell Counter

Critical for the scientific discovery process when it comes to high throughput diagnostic workflows and research-based testing for COVID-19.

Traditionally, Corning’s cloud-based automated cell counter has focused on rapidly capturing the detailed-analysis of 2D cell cultures. The addition of the organoid counting application expands our cell counting capabilities into the vastly developing 3D space. The robust organoid counting software package is designed to meet the unique needs of customers as 3D populations are known to vary in morphologies dependent on numerous environmental factors or protocols. Engineered to account for complex shapes and sizes, the organoid counting software introduces two versions of the 3D counting algorithm.

Version 1 (V1) is for use with cultures of irregular morphology. The machine learning algorithm for V1 is trained to engulf the individual outer membranes within the field of view in order to calculate accurate surface area and orgs./mL data. Version 2 (V2) of the 3D algorithm is for use with spherical objects. Other than obtaining prompt surface area and orgs./mL data; V2 will be optimal for differentiating individual spherical objects within clusters. The software is shipped with a 0.2 mm gridless counting chamber, equipping the user with all the necessary devices to successfully determine their 3D counts with the Corning Cell Counter.

  • Accurate – powered by machine learning artificial intelligence
  • Multi-informative – organoids per milliliter of solution and surface area data
  • Fast – three-second analysis utilizing cloud-based processing
  • Cost-efficient and versatile – compatible with a standard 0.1 mm counting chambers and 0.2 mm counting chambers. No consumables required.
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Corning® Matrigel® Matrix for Organoid Culture

Corning Matrigel Matrix for Organoid Culture is a solubilized basement membrane preparation that has been optimized for organoid culture.

  • Quality tested for ability to form and maintain stable 3D domes/droplets on multi-well plates
  • Elastic Modulus (matrix stiffness) measured using a rheometer
  • Protein concentrations determined by Lowry method
  • Mouse colonies routinely screened for pathogens via Mouse Antibody Production (MAP) testing
  • Extensive PCR testing is performed to screen for a number of pathogens
  • Tested and found negative for bacteria, fungi, and mycoplasma
  • Endotoxin units measured by Limulus Amoebocyte Lysate assay

Verified to support both mouse and human organoid growth and differentiation from healthy and/or diseased tissue, each lot has a specific elastic modulus value indicating the stiffness of the gel formed and is qualified to form stable 3D domes commonly used in organoid culture protocols. Available in 10 ml LDEV-free, Phenol Red-free format.

Corning Matrigel Matrix for Organoid culture is extracted from the Engelbreth-Holm-Swarm (EHS) mouse sarcoma, a tumor rich in extracellular matrix proteins, including Laminin (a major component), Collagen IV, heparin sulfate proteoglycans, entactin/nidogen, and a number of growth factors.

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Cell Culture Solutions

At Corning, cells are in our culture. In our continuous efforts to improve efficiencies and develop new tools and technologies for life science researchers, we have scientists working in Corning R&D labs across the globe, doing what you do every day. From seeding starter cultures to expanding cells for assays, our technical experts understand your challenges and your increased need for more reliable cells and cellular material. Explore our wide selection of cell culture products for each step of the process.
Bioprocess Solutions

Corning customized cell culture products enable efficient scale-up and production in Bioprocess. From vessels to media to surfaces to closed systems, Corning can provide the necessary cell culture platform to accomplish your goal – right from the start.
Bioprocess: Cell Acquisition, Buffer & Media Prep, Seed & Expand, Bioproduction, and Store
 
Drug Discovery Solutions

With our comprehensive line of plasticware, assay products, and Corning® Epic® Technology for label-free detection, we continue to be an industry leader, providing products and services that allow researchers to bring drugs to market more quickly and efficiently.
Drug Discovery: Assay Preparation, Assay Development, Screening, and Storage
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