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Ace+Method+Development+Kits
Catalog Number:
(10404-052)
Supplier:
Bioss
Description:
Orphan nuclear receptor that can act as a repressor or activator of transcription. An important repressor of nuclear receptor signaling pathways such as retinoic acid receptor, retinoid X, vitamin D3 receptor, thyroid hormone receptor and estrogen receptor pathways. May regulate gene expression during the late phase of spermatogenesis. Together with NR2C1, forms the core of the DRED (direct repeat erythroid-definitive) complex that represses embryonic and fetal globin transcription including that of GATA1. Binds to hormone response elements (HREs) consisting of two 5'-AGGTCA-3' half site direct repeat consensus sequences. Plays a fundamental role in early embryonic development and embryonic stem cells. Required for normal spermatogenesis and cerebellum development. Appears to be important for neurodevelopmentally regulated behavior (By similarity). Activates transcriptional activity of LHCG. Antagonist of PPARA-mediated transactivation.
Catalog Number:
(76082-688)
Supplier:
Bioss
Description:
SEMA6A belongs to a subfamily characterized by an extracellular semaphorin domain, a transmembrane domain, and a long cytoplasmic tail. Members of this class can repel sympathetic and dorsal root ganglion axons in vitro, consistent with a traditional role as guidance signals. However, the length of the cytoplasmic tail, which includes an EVL-binding site in SEMA6A and an Src-binding site in SEMA6B, suggests that these semaphorins may also function as receptors. SEMA6A is expressed in developing neural tissue and is required for proper development of the thalamocortical projection. SEMA6A directly links the Ena/VASP and the semaphorin protein families since the SEMA6A protein is capable of selective binding to the protein EVL (Ena/VASP-like protein.
Catalog Number:
(89417-522)
Supplier:
Prosci
Description:
TCTN2 Antibody: TCTN2 is a member of the Tectonic protein family, a group of evolutionarily conserved secreted and transmembrane proteins that regulate the Hedgehog (Hh)-mediated patterning of the neural tube. While the expression pattern and function of TCTN2 is not known, it is 49% similar to TCTN1. TCTN1 is expressed during embryonic development in regions that participate in Hh signaling, beginning in the gastrulation stages in the ventral node. Mice expressing mutant TCTN1 die between E13.5 and E16.5 and display holoprosencephaly, a defect associated with reduced Hh signaling, indicating the role of TCTN1 as an Hh activator. At later stages in development, TCTN1 is thought to also act as a repressor on the Hh pathway in the anterior and posterior neural tube.
Supplier:
TCI America
Description:
CAS Number: 70728-23-3
MDL Number: MFCD02093461 Molecular Formula: C8H8O7 Molecular Weight: 216.15 Purity/Analysis Method: >98.0% (T) Form: Crystal Melting point (°C): 134 Specific rotation [a]20/D: -96 deg (C=0.5, CHCl3) Storage Temperature: <0°C
Catalog Number:
(10354-388)
Supplier:
Bioss
Description:
Ephrin B proteins are thought to play key roles in cellular functions as diverse as neuronal migration and blood vessel development. Ephrin B molecules expressed at the membrane surface bind to the Ephrin B family receptors on target cells during cell to cell contact. This interaction leads to cell signaling in the target cell but also generates a reverse signal in the cell expressing Ephrin B on its surface. This reverse signaling event is thought to be critical for vessel maturation and neuronal development. Importantly, tyrosine phosphorylation of Ephrin B is thought to be a critical component of this reverse signaling event. Recent work demonstrated that Tyr331 of Ephrin B was phosphorylated in HEK293 cells after stimulation by the soluble Ephrin B2 receptor tyrosine kinase.
Catalog Number:
(10748-492)
Supplier:
Prosci
Description:
T-cadherin Antibody: T-cadherin was initially identified as cadherin-type cell adhesion molecule expressed in various neuronal populations in a temporally and spatially restricted pattern during axon growth. T-cadherin is an atypical member of the cadherin family because it does not possess the typical transmembrane and cytoplasmic domains but is instead anchored to the plasma membrane by glycosylphosphatidylinositol (GPI) linkage. T-cadherin may play a role in malignant tumor development as loss of the chromosome locus containing the T-cadherin gene correlates with the development of a variety of cancers. Recently it has been shown that T-cadherin can act as a receptor for hexameric and high-molecular weight forms of adiponectin, suggesting that T-cadherin may also play a role in metabolic regulation.
Catalog Number:
(10354-390)
Supplier:
Bioss
Description:
Ephrin B proteins are thought to play key roles in cellular functions as diverse as neuronal migration and blood vessel development. Ephrin B molecules expressed at the membrane surface bind to the Ephrin B family receptors on target cells during cell to cell contact. This interaction leads to cell signaling in the target cell but also generates a reverse signal in the cell expressing Ephrin B on its surface. This reverse signaling event is thought to be critical for vessel maturation and neuronal development. Importantly, tyrosine phosphorylation of Ephrin B is thought to be a critical component of this reverse signaling event. Recent work demonstrated that Tyr331 of Ephrin B was phosphorylated in HEK293 cells after stimulation by the soluble Ephrin B2 receptor tyrosine kinase.
Catalog Number:
(89280-014)
Supplier:
Genetex
Description:
Rabbit Polyclonal Antibody to WWTR1
Catalog Number:
(TCT3178-200MG)
Supplier:
TCI America
Description:
CAS Number: 30363-03-2
MDL Number: MFCD04116312 Molecular Formula: C21H12Br3N3 Molecular Weight: 546.06 Purity/Analysis Method: >98.0% (HPLC,N) Form: Crystal Color: White Melting point (°C): 361
Supplier:
TCI America
Description:
CAS Number: 112811-65-1
MDL Number: MFCD00153201 Molecular Formula: C8H5F3O3 Molecular Weight: 206.12 Purity/Analysis Method: >98.0% (GC,T) Form: Crystal Color: White Melting point (°C): 118
Catalog Number:
(TCT2238-5G)
Supplier:
TCI America
Description:
CAS Number: 2085-33-8
MDL Number: MFCD00191693 Molecular Formula: C27H18AlN3O3 Molecular Weight: 459.44 Purity/Analysis Method: >98.0% (T) Form: Crystal Color: Pale Yellow Melting point (°C): 418
Catalog Number:
(TCD3491-25G)
Supplier:
TCI America
Description:
CAS Number: 50583-51-2
MDL Number: MFCD02682986 Molecular Formula: C20H18O10 Molecular Weight: 418.35 Purity/Analysis Method: >97.0% (HPLC,T) Form: Crystal Specific rotation [a]20/D: -168 deg (C=1, EtOH)
Supplier:
TCI America
Description:
CAS Number: 31121-11-6
Molecular Formula: C9H13NO Molecular Weight: 151.21 Purity/Analysis Method: >98.0% (GC,T) Form: Clear Liquid Boiling point (°C): 140 Specific Gravity (20/20): 1.08 Lambda max.: 245 nm (Hexane)Storage Temperature: 0-10°C
Supplier:
TCI America
Description:
CAS Number: 627-18-9
MDL Number: MFCD00002942 Molecular Formula: C3H7BrO Molecular Weight: 138.99 Purity/Analysis Method: >93.0% (GC) Form: Clear Liquid Boiling point (°C): 140 Flash Point (°C): 102 Specific Gravity (20/20): 1.60
Catalog Number:
(TCB3800-25G)
Supplier:
TCI America
Description:
CAS Number: 35822-58-3
MDL Number: MFCD01075696 Molecular Formula: C11H15BrO2 Molecular Weight: 259.14 Purity/Analysis Method: >97.0% (GC) Form: Clear Liquid Boiling point (°C): 116 Flash Point (°C): 112 Specific Gravity (20/20): 1.29
Supplier:
TCI America
Description:
CAS Number: 105669-53-2
MDL Number: MFCD04039895 Molecular Formula: C6H14N2O Molecular Weight: 130.19 Purity/Analysis Method: >97.0% (GC,T) Form: Clear Liquid Boiling point (°C): 96 Flash Point (°C): 70 Specific Gravity (20/20): 0.95
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