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Ace+Method+Development+Kits
Supplier:
TCI America
Description:
CAS Number: 39608-31-6
MDL Number: MFCD00021747 Molecular Formula: C11H13NO4 Molecular Weight: 223.23 Purity/Analysis Method: >97.0% (HPLC) Form: Clear Liquid
Supplier:
TCI America
Description:
CAS Number: 102390-98-7
Molecular Formula: C12H19F9O3Si Molecular Weight: 410.35 Purity/Analysis Method: >97.0% (GC) Form: Clear Liquid Color: Colorless Specific Gravity (20/20): 1.24
Catalog Number:
(10396-464)
Supplier:
Bioss
Description:
Plays an important role in the normal skeletal development. May regulate the expression of other genes involved in chondrogenesis by acting as a transcription factor for these genes.
Catalog Number:
(TCP2112-1G)
Supplier:
TCI America
Description:
CAS Number: 3130-75-4
MDL Number: MFCD00196079 Molecular Formula: C12H11NO4 Molecular Weight: 233.22 Purity/Analysis Method: >98.0% (HPLC,T) Form: Crystal Color: White Melting point (°C): 117 Lambda max.: 290 nm (EtOH)
Supplier:
TCI America
Description:
CAS Number: 348-67-4
MDL Number: MFCD00002622 Molecular Formula: C5H11NO2S Molecular Weight: 149.21 Purity/Analysis Method: >99.0% (T) Form: Crystal Specific rotation [a]20/D: -24 deg (C=4, HCl (1+1))
Catalog Number:
(77438-422)
Supplier:
Bioss
Description:
This gene encodes an eye lens-specific protein found at the junctions of lens fiber cells, where it may contribute to cell junctional organization. It acts as a receptor for calmodulin, and may play an important role in both lens development and cataractogenesis. Mutations in this gene have been associated with cataract formation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Sep 2009]
Catalog Number:
(10461-184)
Supplier:
Bioss
Description:
Plays a role as a transcriptional repressor during development. May play a role in the control of cell survival. Overexpression of RERE recruits BAX to the nucleus particularly to POD and triggers caspase-3 activation, leading to cell death.
Catalog Number:
(75793-892)
Supplier:
Prosci
Description:
bHLH proteins are essential for neurogenesis, myogenesis, hematopoiesis and sex determination. HES1 (Hairy and Enhancer of Split 1) is a basic Helix-Loop-Helix (bHLH) transcriptional repressor regulated by the Notch pathway and expressed in various tissues. HES1 is well known in development of different tissues, particularly endoderm derived endocrine organs like pancreas and neuroendocrine cells of lung. HES1 controls normal development by regulating proliferation and differentiation and so cell fate. Notch signaling plays both oncogenic and tumor suppressor roles depending on cell type. In contrast to T cell acute lymphoblastic leukemia (ALL), where Notch activation promotes leukemogenesis, induction of Notch signaling in B cell ALL (B-ALL) leads to growth arrest and apoptosis. The Notch target HES1 is sufficient to reproduce this tumor suppressor phenotype in B-ALL by interacting and activating PARP-1 and regulating proapoptotic signals.
Catalog Number:
(10798-042)
Supplier:
Prosci
Description:
CD3e molecule, epsilon is also known as CD3E, is a T-cell surface single-pass type I membrane glycoprotein. CD3E contains 1 Ig-like (immunoglobulin-like) domain and 1 ITAM domain. CD3E, together with CD3-gamma, CD3-delta and CD3-zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T cell receptor-CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The genes encoding the epsilon, gamma and delta polypeptides are located in the same cluster on chromosome 11. The epsilon polypeptide plays an essential role in T-cell development. CD3E plays an essential role in T-cell development, and defects in CD3E gene cause severe immunodeficiency. CD3E gene has also been linked to a susceptibility to type I diabetes in women. CD3E has been shown to interact with TOP2B, CD3EAP and NCK2.
Catalog Number:
(10464-124)
Supplier:
Bioss
Description:
Lipin 1 is a member of the Lipin family of nuclear proteins. This family contains three members: Lipin 1, Lipin 2 and Lipin 3, all of which contain a nuclear signal sequence, a highly conserved amino-terminal (NLIP) domain and a carboxy-terminal (CLIP) domain. LPIN1 (Lipin 1) is crucial for normal adipose tissue development and metabolism. LPIN1 selectively activates a subset of PGC1 alpha target pathways, including fatty acid oxidation and mitochondrial oxidative phosphorylation by inducing expression of the nuclear receptor PPARalpha. LPIN1 also inactivates the lipogenic program and suppresses circulating lipid levels. An abundance of LPIN1 promotes fat accumulation and insulin sensitivity, whereas a deficiency in LPIN1 may deter normal adipose tissue development, resulting in insulin resistance and lipodystrophy, a heterogeneous group of disorders characterized by loss of body fat, fatty liver, hypertriglyceridemia and insulin resistance.
Catalog Number:
(10412-898)
Supplier:
Bioss
Description:
Separase is a cysteine protease that is essential for mitotic progression by separating sister chromatids. Each cell must receive one chromatid of every chromosome, during mitosis. Cohesin plays an important role in cohering sister chromatids during the prophase through anaphase stages of mitosis, making certain that genomic information is replicated accurately. As the cellular division process continues, separase destroys cohesin by means of cleavage, allowing the chromatids to separate and divide with the cell. Separase activity is highly regulated. It not only cleaves cohesin at the onset of anaphase but also cleaves itself, promoting downregulation of separase after anaphase. Should a human cell become an aneuploid (one too many or too few chromatids), the embryo most likely will not survive. Should the embryo survive, it will most likely develop severe birth defects or later develop malignant cancers.
Catalog Number:
(10448-592)
Supplier:
Bioss
Description:
CGI-99 is a 244 amino acid protein that localizes to the nucleus, as well as to the cytoplasm, and belongs to the UPF0568 family. Expressed in a variety of tissues with particularly high levels in heart and skeletal muscle, CGI-99 functions as a homodimer that interacts with Ninein and is thought to regulate Ninein function. CGI-99 is overexpressed in brain tumor tissue, suggesting a role in tumor development and metastasis. The gene encoding CGI-99 maps to human chromosome 14, which houses over 700 genes and comprises nearly 3.5% of the human genome. Chromosome 14 encodes the presinilin 1 (PSEN1) gene, which is one of the three key genes associated with the development of Alzheimer's disease (AD). The SERPINA1 gene is also located on chromosome 14 and, when defective, leads to the genetic disorder ?-antitrypsin deficiency, which is characterized by severe lung complications and liver dysfunction.
Catalog Number:
(470129-200)
Supplier:
TMW Media Group
Description:
Learn healthy eating habits and help kids avoid the flu! fun music and lyrics with Grammy award winners The Kingston Trio and Minstrel Magicians Julie and Brownie. Join the Grammy award winning Kingston Trio along with their guests Julie and Brownie for a song filled program as kids learn how to avoid colds and flu and develop healthy eating choices that will last a lifetime.
Supplier:
TCI America
Description:
CAS Number: 23790-39-8
Molecular Formula: C15H28O Molecular Weight: 224.39 Purity/Analysis Method: >95.0% (GC) Form: Clear Liquid Boiling point (°C): 134 Specific Gravity (20/20): 0.89
Supplier:
TCI America
Description:
CAS Number: 189028-93-1
MDL Number: MFCD08061377 Molecular Formula: C20H18FNO4 Molecular Weight: 355.37 Purity/Analysis Method: >98.0% (HPLC,N) Form: Crystal Color: White Melting point (°C): 92
Catalog Number:
(TCA2523-100MG)
Supplier:
TCI America
Description:
CAS Number: 875770-34-6
MDL Number: MFCD20134145 Molecular Formula: C18H32N6O5S Molecular Weight: 444.55 Purity/Analysis Method: >95.0% (HPLC) Form: Crystal Melting point (°C): 110 Storage Temperature: <0°C
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