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Ace+Method+Development+Kits
Catalog Number:
(75793-890)
Supplier:
Prosci
Description:
bHLH proteins are essential for neurogenesis, myogenesis, hematopoiesis and sex determination. HES1 (Hairy and Enhancer of Split 1) is a basic Helix-Loop-Helix (bHLH) transcriptional repressor regulated by the Notch pathway and expressed in various tissues. HES1 is well known in development of different tissues, particularly endoderm derived endocrine organs like pancreas and neuroendocrine cells of lung. HES1 controls normal development by regulating proliferation and differentiation and so cell fate. Notch signaling plays both oncogenic and tumor suppressor roles depending on cell type. In contrast to T cell acute lymphoblastic leukemia (ALL), where Notch activation promotes leukemogenesis, induction of Notch signaling in B cell ALL (B-ALL) leads to growth arrest and apoptosis. The Notch target HES1 is sufficient to reproduce this tumor suppressor phenotype in B-ALL by interacting and activating PARP-1 and regulating proapoptotic signals.
Catalog Number:
(10412-894)
Supplier:
Bioss
Description:
Separase is a cysteine protease that is essential for mitotic progression by separating sister chromatids. Each cell must receive one chromatid of every chromosome, during mitosis. Cohesin plays an important role in cohering sister chromatids during the prophase through anaphase stages of mitosis, making certain that genomic information is replicated accurately. As the cellular division process continues, separase destroys cohesin by means of cleavage, allowing the chromatids to separate and divide with the cell. Separase activity is highly regulated. It not only cleaves cohesin at the onset of anaphase but also cleaves itself, promoting downregulation of separase after anaphase. Should a human cell become an aneuploid (one too many or too few chromatids), the embryo most likely will not survive. Should the embryo survive, it will most likely develop severe birth defects or later develop malignant cancers.
Catalog Number:
(10450-672)
Supplier:
Bioss
Description:
Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Among GPI-anchored ephrin-A ligands, EFNA5 most probably constitutes the cognate/functional ligand for EPHA5. Functions as an axon guidance molecule during development and may be involved in the development of the retinotectal, entorhino-hippocampal and hippocamposeptal pathways. Together with EFNA5 plays also a role in synaptic plasticity in adult brain through regulation of synaptogenesis. In addition to its function in the nervous system, the interaction of EPHA5 with EFNA5 mediates communication between pancreatic islet cells to regulate glucose-stimulated insulin secretion (By similarity).
Catalog Number:
(10464-118)
Supplier:
Bioss
Description:
Lipin 1 is a member of the Lipin family of nuclear proteins. This family contains three members: Lipin 1, Lipin 2 and Lipin 3, all of which contain a nuclear signal sequence, a highly conserved amino-terminal (NLIP) domain and a carboxy-terminal (CLIP) domain. LPIN1 (Lipin 1) is crucial for normal adipose tissue development and metabolism. LPIN1 selectively activates a subset of PGC1 alpha target pathways, including fatty acid oxidation and mitochondrial oxidative phosphorylation by inducing expression of the nuclear receptor PPARalpha. LPIN1 also inactivates the lipogenic program and suppresses circulating lipid levels. An abundance of LPIN1 promotes fat accumulation and insulin sensitivity, whereas a deficiency in LPIN1 may deter normal adipose tissue development, resulting in insulin resistance and lipodystrophy, a heterogeneous group of disorders characterized by loss of body fat, fatty liver, hypertriglyceridemia and insulin resistance.
Catalog Number:
(10750-844)
Supplier:
Prosci
Description:
DCLK1 Antibody: DCLK1 is one of three doublecortin-like kinases similar to the Ca2+/calmodulin-dependent protein kinase (CaMK) family. DCLK1 mRNA, like that of the homologous DCLK2 and DCLK3, is highly expressed in adult brain, but only DCLK1 and DCLK2 transcripts are present in human fetal brain and the developing mouse embryo, suggesting that DCLK1 and DCLK2 may play roles in cortical development. The DCLK proteins are homologous to Doublecortin (DCX), a gene that is mutated in X-linked human lissencephaly. In mouse models where the DCX gene has been disrupted, DCLK1 expression increases slightly and appears to compensate for the loss of DCX, as mice mutant for both DCX and DCLK1 show a severe phenotype including perinatal lethality, disorganized neocortical layering, and profound hippocampal cytoarchitectural disorganization. Unlike DCLK1, DCLK2 expression does not change in DCX-null mice.
Catalog Number:
(77440-448)
Supplier:
Bioss
Description:
Component of secretory vesicle machinery in developing neurons that acts as a regulator of neurite outgrowth. Regulates the secretory vesicle transport by controlling the accumulation of Rab6-containing secretory vesicles in the pericentrosomal region restricting anterograde secretory transport during the early phase of neuronal differentiation, thereby inhibiting neuritogenesis.
Catalog Number:
(10471-658)
Supplier:
Bioss
Description:
Probable transcription factor required for the expression of a subset of genes involved in interneurons migration and development. Functions in the specification of cortical interneuron subtypes and in the migration of GABAergic interneuron precursors from the subpallium to the cerebral cortex.
Catalog Number:
(10471-660)
Supplier:
Bioss
Description:
Probable transcription factor required for the expression of a subset of genes involved in interneurons migration and development. Functions in the specification of cortical interneuron subtypes and in the migration of GABAergic interneuron precursors from the subpallium to the cerebral cortex.
Supplier:
TCI America
Description:
CAS Number: 4097-89-6
MDL Number: MFCD00008177 Molecular Formula: C6H18N4 Molecular Weight: 146.24 Purity/Analysis Method: >98.0% (T) Form: Clear Liquid Color: Colorless Boiling point (°C): 114 Flash Point (°C): 113 Specific Gravity (20/20): 0.98
Supplier:
TCI America
Description:
CAS Number: 497-76-7
MDL Number: MFCD00016915 Molecular Formula: C12H16O7 Molecular Weight: 272.25 Purity/Analysis Method: >95.0% (HPLC) Form: Crystal Melting point (°C): 198 Specific rotation [a]20/D: -65.5 deg (C=4, H2O)
Catalog Number:
(89360-292)
Supplier:
Genetex
Description:
The c-Myc protein is a transcription factor, which is encoded by the c-Myc gene on human chromosome 8q24. c-Myc is commonly activated in a variety of tumor cells and plays an important role in cellular proliferation, differentiation, apoptosis and cell cycle progression. The phosphorylation of c-Myc has been investigated and previous studies have suggested a functional association between phosphorylation at Thr58/Ser62 by glycogen synthase kinase 3, cyclin-dependent kinase, ERK2 and C-Jun N-terminal Kinase (JNK) in cell proliferation and cell cycle regulation. Studies also have shown that c-Myc is essential for tumor cell development in vasculogenesis and angiogenesis that distribute blood throughout the cells, and which brought extensive attention in the development of new therapeutic approach for cancer treatment.
Catalog Number:
(10103-730)
Supplier:
Prosci
Description:
The exact function of ND6 remains unknown.
Catalog Number:
(TCH0134-100ML)
Supplier:
TCI America
Description:
CAS Number: 111-26-2
MDL Number: MFCD00008240 Molecular Formula: C6H15N Molecular Weight: 101.19 Purity/Analysis Method: >99.0% (GC,T) Form: Clear Liquid Boiling point (°C): 130 Melting point (°C): -19 Flash Point (°C): 27 Specific Gravity (20/20): 0.77
Supplier:
TCI America
Description:
CAS Number: 71418-44-5
MDL Number: MFCD00036951 Molecular Formula: C10H11BrN2O2 Molecular Weight: 271.11 Purity/Analysis Method: >98.0% (HPLC) Form: Crystal Melting point (°C): 162 Lambda max.: 395 nm (H2O)Storage Temperature: <0°C
Catalog Number:
(TCD0600-100G)
Supplier:
TCI America
Description:
CAS Number: 59-92-7
MDL Number: MFCD00002598 Molecular Formula: C9H11NO4 Molecular Weight: 197.19 Purity/Analysis Method: >98.0% (HPLC,T) Form: Crystal Melting point (°C): 278 Specific rotation [a]20/D: -12 deg (C=5, 1mol/L HCl)
Supplier:
TCI America
Description:
CAS Number: 446-17-3
MDL Number: MFCD00013306 Molecular Formula: C7H3F3O2 Molecular Weight: 176.09 Purity/Analysis Method: >97.0% (GC,T) Form: Crystal Color: White Melting point (°C): 98
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