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Ace+Method+Development+Kits
Catalog Number:
(76118-262)
Supplier:
Bioss
Description:
CGI-99 is a 244 amino acid protein that localizes to the nucleus, as well as to the cytoplasm, and belongs to the UPF0568 family. Expressed in a variety of tissues with particularly high levels in heart and skeletal muscle, CGI-99 functions as a homodimer that interacts with Ninein and is thought to regulate Ninein function. CGI-99 is overexpressed in brain tumor tissue, suggesting a role in tumor development and metastasis. The gene encoding CGI-99 maps to human chromosome 14, which houses over 700 genes and comprises nearly 3.5% of the human genome. Chromosome 14 encodes the presinilin 1 (PSEN1) gene, which is one of the three key genes associated with the development of Alzheimer's disease (AD). The SERPINA1 gene is also located on chromosome 14 and, when defective, leads to the genetic disorder ?-antitrypsin deficiency, which is characterized by severe lung complications and liver dysfunction.
Catalog Number:
(89416-304)
Supplier:
Prosci
Description:
FABP7 Antibody: FABP7 was initially isolated from a human fetal brain cDNA library and whose mRNA was expressed in adult brain and muscle tissues at low levels. The protein encoded by this gene is a member of the fatty acid binding protein (FABPs) family, a group of small, highly conserved, cytoplasmic proteins that bind long-chain fatty acids and other hydrophobic ligands. FABPs are thought to play roles in fatty acid uptake, transport, and metabolism. FABP7 is a downstream gene of the Pax6 transcription factor and has been suggested to be essential for the maintenance of neuroepithelial cells during early cortical development. More recently, FABP7 was found to be frequently expressed in melanomas. Down-regulation of FABP7 through RNAi expression could reduce in vitro cell proliferation and Matrigel invasion, suggesting that FABP7 may be a potential target for the development of diagnostic and therapeutic tools.
Catalog Number:
(10668-702)
Supplier:
Bioss
Description:
SMAD regulates gene expression by interacting with different classes of transcription factors including DNA-binding multi-zinc finger proteins. SIP1, for SMAD interacting protein 1, is a member of the delta-EF1/Zfh1 family of 2-handed zinc finger/homeodomain proteins. SIP1 contains a SMAD-binding domain, a homeodomain and two clusters of zinc fingers on the N- and C-termini. SIP1, also known as SMADIP1, ZFHX1B and ZEB2 (zinc finger E-box-binding protein 2), can be induced by TGF∫ treatment. SIP1 plays a crucial role in normal embryonic development of neural structures and the neural crest. The human SIP1 gene maps to chromosome 2q22. Mutations in the SIP1 gene cause a form of Hirschsprung disease (HSCR). Patients with SIP1 mutations show mental retardation, delayed motor development, epilepsy, microcephaly, distinct facial features and/or congenital heart disease—all symptoms of HSCR.
Catalog Number:
(89417-356)
Supplier:
Prosci
Description:
DCLK1 Antibody: DCLK1 is one of three doublecortin-like kinases similar to the Ca2+/calmodulin-dependent protein kinase (CaMK) family. DCLK1 mRNA, like that of the homologous DCLK2 and DCLK3, is highly expressed in adult brain, but only DCLK1 and DCLK2 transcripts are present in human fetal brain and the developing mouse embryo, suggesting that DCLK1 and DCLK2 may play roles in cortical development. The DCLK proteins are homologous to Doublecortin (DCX), a gene that is mutated in X-linked human lissencephaly. In mouse models where the DCX gene has been disrupted, DCLK1 expression increases slightly and appears to compensate for the loss of DCX, as mice mutant for both DCX and DCLK1 show a severe phenotype including perinatal lethality, disorganized neocortical layering, and profound hippocampal cytoarchitectural disorganization. Unlike DCLK1, DCLK2 expression does not change in DCX-null mice.
Supplier:
TCI America
Description:
CAS Number: 39961-95-0
MDL Number: MFCD00191979 Molecular Formula: C6H14N2 Molecular Weight: 264.28 Purity/Analysis Method: >98.0% (T) Form: Crystal Melting point (°C): 273 Specific rotation [a]20/D: 12 deg (C=2.5, H2O)
Supplier:
TCI America
Description:
CAS Number: 17016-83-0
MDL Number: MFCD00010847 Molecular Formula: C6H11NO2 Molecular Weight: 129.16 Purity/Analysis Method: >98.0% (GC) Form: Crystal Melting point (°C): 72 Specific rotation [a]20/D: -17.5 deg (C=6, EtOH)
Catalog Number:
(TCP0178-001G)
Supplier:
TCI America
Description:
CAS Number: 1464-44-4
MDL Number: MFCD03410292 Molecular Formula: C12H16O6 Molecular Weight: 256.25 Purity/Analysis Method: >99.0% (GC) Form: Crystal Melting point (°C): 173 Specific rotation [a]20/D: -70.5 deg (C=2, H2O)
Catalog Number:
(10110-840)
Supplier:
Prosci
Description:
LAYN contains 1 C-type lectin domain. It is the receptor for hyaluronate.
Catalog Number:
(10110-526)
Supplier:
Prosci
Description:
The exact function of LOC391766 remains unknown.
Catalog Number:
(10111-552)
Supplier:
Prosci
Description:
The exact function of C20orf30 remains unknown.
Catalog Number:
(10101-946)
Supplier:
Prosci
Description:
The exact function of this protein remains unknown.
Catalog Number:
(10110-522)
Supplier:
Prosci
Description:
The exact function of LOC344065 remains unknown.
Catalog Number:
(10109-580)
Supplier:
Prosci
Description:
SHMT2 plays a role in interconversion of serine and glycine.
Catalog Number:
(10110-462)
Supplier:
Prosci
Description:
The exact function of LOC729745 remains unknown.
Catalog Number:
(10111-806)
Supplier:
Prosci
Description:
The exact function of this protein remains unknown.
Catalog Number:
(10108-376)
Supplier:
Prosci
Description:
The exact functions of DKFZP564O0523 remain unknown.
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