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Ace+Method+Development+Kits
Catalog Number:
(10372-452)
Supplier:
Bioss
Description:
Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands. Phosphorylates PTK2/FAK1. Regulates both cell death/survival balance and positional information. Required for the molecular mechanisms orchestration during intestine organogenesis; involved in the development of enteric nervous system and renal organogenesis during embryonic life, and promotes the formation of Peyer's patch-like structures, a major component of the gut-associated lymphoid tissue. Modulates cell adhesion via its cleavage by caspase in sympathetic neurons and mediates cell migration in an integrin (e.g. ITGB1 and ITGB3)-dependent manner. Involved in the development of the neural crest. Active in the absence of ligand, triggering apoptosis through a mechanism that requires receptor intracellular caspase cleavage. Acts as a dependence receptor; in the presence of the ligand GDNF in somatotrophs (within pituitary), promotes survival and down regulates growth hormone (GH) production, but triggers apoptosis in absence of GDNF. Regulates nociceptor survival and size. Triggers the differentiation of rapidly adapting (RA) mechanoreceptors. Mediator of several diseases such as neuroendocrine cancers; these diseases are characterized by aberrant integrins-regulated cell migration.
Catalog Number:
(AA33261-K4)
Catalog Number:
(10371-922)
Supplier:
Bioss
Description:
LIMK1 is a protein kinase which regulates actin filament dynamics. Phosphorylates and inactivates the actin binding/depolymerizing factor cofilin, thereby stabilizing the actin cytoskeleton. LIMK1 may be involved in brain development; it is highly expressed in both adult and fetal nervous system. Detected ubiquitously throughout the different regions of adult brain, with highest levels in the cerebral cortex. Expressed to a lesser extent in heart and skeletal muscle.
Catalog Number:
(10105-570)
Supplier:
Prosci
Description:
TBX5 is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This gene is closely linked to related family member T-box 3 (ulnar mammary syndrome) on human chromosome 12. The encoded protein may play a role in heart development and specification of limb identity. Mutations in this gene have been associated with Holt-Oram syndrome, a developmental disorder affecting the heart and upper limbs. Several transcript variants encoding different isoforms have been described for this gene.
Supplier:
TCI America
Description:
CAS Number: 62961-64-2
MDL Number: MFCD00008876 Molecular Formula: C10H18O6 Molecular Weight: 234.25 Purity/Analysis Method: >98.0% (GC) Form: Clear Liquid Color: Colorless Flash Point (°C): 110 Specific Gravity (20/20): 1.12 Specific rotation [a]20/D: -17 deg (neat)
Supplier:
PeproTech, Inc.
Description:
FGF-acidic is one of 23 known members of the FGF family. Proteins of this family play a central role during prenatal development, postnatal growth and regeneration of a variety of tissues, by promoting cellular proliferation and differentiation. FGF-acidic is a non-glycosylated heparin binding growth factor that is expressed in the brain, kidney, retina, smooth muscle cells, bone matrix, osteoblasts, astrocytes and endothelial cells. FGF-acidic has the ability to signal through all the FGF receptors. Recombinant Murine FGF-acidic is a 15.9 kDa protein consisting of 141 amino acid residues.
Catalog Number:
(TCM1706-1G)
Supplier:
TCI America
Description:
CAS Number: 155155-64-9
Molecular Formula: C26H33NO12S Molecular Weight: 583.61 Purity/Analysis Method: >97.0% (HPLC) Form: Crystal Melting point (°C): 183 Specific rotation [a]20/D: -121 deg (C=1, CHCl3) Storage Temperature: <0°C
Catalog Number:
(TCC2795-20MG)
Supplier:
TCI America
Description:
CAS Number: 33404-34-1
MDL Number: MFCD00069842 Molecular Formula: C18H32O16 Molecular Weight: 504.44 Purity/Analysis Method: >95.0% (HPLC) Form: Crystal Melting point (°C): 209 Specific rotation [a]20/D: 24 deg (C=1, H2O) Storage Temperature: <0°C
Supplier:
TCI America
Description:
(stabilized with KOH)
CAS Number: 764-99-8 MDL Number: MFCD00054610 Molecular Formula: C8H14O3 Molecular Weight: 158.20 Purity/Analysis Method: >98.0% (GC) Form: Clear Liquid Boiling point (°C): 197 Flash Point (°C): 71 Specific Gravity (20/20): 0.97
Catalog Number:
(TCS0428-001G)
Supplier:
TCI America
Description:
[Cross-linking Reagent]
CAS Number: 55750-63-5 MDL Number: MFCD00043043 Molecular Formula: C14H16N2O6 Molecular Weight: 308.29 Purity/Analysis Method: >98.0% (N) Form: Crystal Color: White Melting point (°C): 71 Storage Temperature: 0-10°C
Catalog Number:
(10393-716)
Supplier:
Bioss
Description:
The protein encoded by this gene is a member of the dual specificity protein kinase family, which acts as a mitogen-activated protein (MAP) kinase kinase. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. This protein kinase lies upstream of MAP kinases and stimulates the enzymatic activity of MAP kinases upon wide variety of extra- and intracellular signals. As an essential component of MAP kinase signal transduction pathway, this kinase is involved in many cellular processes such as proliferation, differentiation, transcription regulation and development.
Catalog Number:
(10751-392)
Supplier:
Prosci
Description:
EIG121 Antibody: EIG121 (Estrogen-induced gene 121 protein) is thought to play a role as a marker of hyperestrogenic state and estrogen-related type I endometrial carcinoma. It belongs to the UPF0577 family. It is a 1013 amino acid single-pass transmembrane protein that, though expressed in normal endometrium, is overexpressed in endometriod tumors. As an evolutionarily conserved gene, EIG121 is also expressed during early xenopus development, showing maximum expression at the gastrula stage.
Catalog Number:
(10085-438)
Supplier:
Proteintech
Description:
CXCR7 (C-X-C chemokine receptor type 7), also known as RDC1, is a member of the G-protein coupled receptor family. CXCR7 can bind the chemokines CXCL11 and CXCL12 with high affinity, and it also acts as coreceptor with CXCR4 for a restricted number of HIV isolates. Expression of CXCR7 has been associated with cardiac development as well as with tumor growth and progression. This antibody recognizes endogenous CXCR7, which has an experimentally determined molecular weight of 50 kDa .
Catalog Number:
(10426-858)
Supplier:
Bioss
Description:
The protein encoded by this gene belongs to the ETS family of transcription factors, which is a large group of evolutionarily conserved transcriptional regulators that play an important role in a variety of cellular processes throughout development and differentiation, and are involved in oncogenesis as well. This protein is predominantly expressed in hematopoietic tissues. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene (PMID:11108721).[provided by RefSeq, May 2011].
Catalog Number:
(10464-100)
Supplier:
Bioss
Description:
This gene encodes a member of the LIM/homeodomain family of transcription factors. The encoded protein binds to the enhancer region of the insulin gene, among others, and may play an important role in regulating insulin gene expression. The encoded protein is central to the development of pancreatic cell lineages and may also be required for motor neuron generation. Mutations in this gene have been associated with maturity-onset diabetes of the young. [provided by RefSeq, Jul 2008]
Catalog Number:
(10373-522)
Supplier:
Bioss
Description:
This gene encodes a member of the Polycomb-group (PcG) family. PcG family members form multimeric protein complexes, which are involved in maintaining the transcriptional repressive state of genes over successive cell generations. This protein associates with the embryonic ectoderm development protein, the VAV1 oncoprotein, and the X-linked nuclear protein. This protein may play a role in the hematopoietic and central nervous systems. Multiple alternatively splcied transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Feb 2011].
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