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Ace+Method+Development+Kits
Catalog Number:
(10782-404)
Supplier:
Biosensis
Description:
The neural adhesion molecule Contactin-6, also known as NB-3, is a contactin/F3 subgroup member of immunoglobulin superfamily. It is expressed exclusively in the nervous system and mainly upregulated at the early postnatal stage during mouse brain development. Employing Northern blot analysis Kamei et al found that amongst different regions of the adult human nervous system cerebellum expressed highest level of NB-3 mRNA. The expression of NB-3 in the cerebellum increases until adulthood. In contrast, the expression in the cerebrum declines to a low level after postnatal day 7. NB-3 like other neural recognition molecules plays a vitally important role in axonal guidance during development, plasticity, and maintenance of synaptic connections in the adult brain. Cui et al recently showed that NB-3 acts as a novel Notch ligand to participate in oligodendrocyte generation. Furthermore, NB-3 triggers nuclear translocation of the Notch intracellular domain and promotes oligodendrogliogenesis from progenitor cells and differentiation of oligodendrocyte precursor cells via Deltex1. In primary oligodendrocytes, NB-3 increases myelin-associated glycoprotein transcripts. Hence, the NB-3/Notch signaling pathway may be worthwhile a closer examination for its potential for the treatment of demyelinating diseases. Human NB-3 shares with rat NB-3 86% identity in nucleotide sequences and 90% identity in amino acid sequences. FUNCTION: Contactins mediate cell surface interactions during nervous system development. Participates in oligodendrocytes generation by acting as a ligand of NOTCH1. Its association with NOTCH1 promotes NOTCH1 activation through the released notch intracellular domain (NICD) and subsequent translocation to the nucleus. Involved in motor coordination. SUBCELLULAR LOCATION: Cell membrane; lipid-anchor; GPI-anchor. ALTERNATIVE PRODUCTS: 2 named isoforms produced by alternative splicing. TISSUE SPECIFICITY: Expressed in brain. In brain, it is preferentially expressed in the accessory olfactory bulb, layers II/III and V of the cerebral cortex, piriform cortex, anterior thalamic nuclei, locus coeruleus of the pons and mesencephalic trigeminal nucleus and in Purkinje cells of the cerebellum.
Catalog Number:
(CA10037-224)
Supplier:
Rockland Immunochemical
Description:
Anti-Mouse Serum (Goat) Antibody is suitable for immunoprecipitation, immunodiffusion, conjugation and most immunological methods requiring high titer and specificity.
Catalog Number:
(89051-324)
Supplier:
Ace Glass
Description:
This adapter features an Ace-Thred at the bottom and two smaller Ace-Threds at the top, with one being offset.
Supplier:
TCI America
Description:
CAS Number: 582-52-5
MDL Number: MFCD00005544 Molecular Formula: C12H20O6 Molecular Weight: 260.29 Purity/Analysis Method: >97.0% (GC) Form: Crystal Melting point (°C): 110 Specific rotation [a]20/D: -18.5 deg (C=5, H2O)
Catalog Number:
(77440-716)
Supplier:
Bioss
Description:
This gene encodes an enzyme that belongs to a conserved family of serine/threonine protein kinases. Members of this dual specificity kinase family are thought to function in the regulation of cell differentiation and proliferation, survival, and in development. Alternate splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Aug 2013]
Supplier:
MilliporeSigma
Description:
Meets ACS Specifications, Meets Reagent Specifications for testing USP/NF monographs.
Catalog Number:
(TCM1759-1G)
Supplier:
TCI America
Description:
CAS Number: 62812-42-4
Molecular Formula: C19H22O9S Molecular Weight: 426.44 Purity/Analysis Method: >98.0% (HPLC) Form: Crystal Melting point (°C): 119 Specific rotation [a]20/D: -19 deg (C=1, CHCl3) Storage Temperature: 0-10°C
Catalog Number:
(TCT0548-100ML)
Supplier:
TCI America
Description:
CAS Number: 110-95-2
MDL Number: MFCD00008337 Molecular Formula: C7H18N2 Molecular Weight: 130.24 Purity/Analysis Method: >98.0% (GC,T) Form: Clear Liquid Color: Colorless Boiling point (°C): 145 Flash Point (°C): 56 Specific Gravity (20/20): 0.78
Supplier:
TCI America
Description:
CAS Number: 174813-82-2
MDL Number: MFCD12545951 Molecular Formula: C30H33ClN2O2RuS Molecular Weight: 622.19 Purity/Analysis Method: >90% (HPLC) Form: Crystal Color: Yellow
Supplier:
Ace Glass
Description:
Reflector, for use with Ace-Hanovia U.V
Catalog Number:
(10489-156)
Supplier:
Bioss
Description:
E3 ubiquitin-protein ligase that mediates polyubiquitination of CD4. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. May play a role in ubuquitin-dependent protein sorting in developmenting spermatids.
Catalog Number:
(10081-256)
Supplier:
Proteintech
Description:
Homeobox protein Nkx-2.1 (NKX2-1), also named Thyroid nuclear factor 1,Thyroid transcription factor 1(TTF1). It is a transcription factor that binds and activates the promoter of thyroid specific genes such as thyroglobulin, thyroperoxidase, and thyrotropin receptor. Crucial in the maintenance of the thyroid differentiation phenotype. May play a role in lung development and surfactant homeostasis. Defects in NKX2-1 are the cause of benign hereditary chorea (BHC), choreoathetosis, hypothyroidism, and neonatal respiratory distress (CHNRD).
Catalog Number:
(10750-508)
Supplier:
Prosci
Description:
erbB-2 Antibody: The ErbB family consists of four closely related tyrosine kinase receptors that act as potent mediators of normal cell growth and development. Aberrant expression or function of one or more of these receptors can play a major role in the development and evolution of cancer. ErbB-2, also known as HER2, has been implicated in the evolution of both breast and gastric cancers, and is evident in other cancer types such as ovarian and salivary gland tumors. ErbB-2 possesses an active tyrosine kinase domain, but no direct ligand has been identified yet. ErbB-2 is the preferred binding partner to the other members of the ErbB family and is thought to act primarily through the Ras-MAPK, PI3k-PKB/Akt, and PLC-PKC signaling pathways. Numerous anti-cancer strategies have been employed against erbB-2, such as antibody-based therapies to prevent ligand binding or receptor activation through dimerization, antibody-dependent cell mediated cytotoxicity, in addition to direct kinase inhibition to prevent molecular activation/downstream signaling.
Catalog Number:
(75793-090)
Supplier:
Prosci
Description:
Neutrophils are key components of the inflammatory response and as such contribute to the killing of microorganisms. In addition, recent evidence suggests their involvement in the development of the immune response. The Nimp-R14 mAb displays features of an optimal reagent allowing the selective depletion of mouse neutrophils in vivo.
Catalog Number:
(77437-284)
Supplier:
Bioss
Description:
Gamma-enolase, also known as enolase 2 (ENO2) or neuron specific enolase (NSE), is an enzyme that in humans is encoded by the ENO2 gene. Gamma-enolase is a phosphopyruvate hydratase. Gamma-enolase is one of the three enolase isoenzymes found in mammals. This isoenzyme, a homodimer, is found in mature neurons and cells of neuronal origin. A switch from alpha enolase to gamma enolase occurs in neural tissue during development in rats and primates.
Supplier:
TCI America
Description:
CAS Number: 113826-06-5
MDL Number: MFCD00010834 Molecular Formula: C10H12O4S Molecular Weight: 228.26 Purity/Analysis Method: >98.0% (GC) Form: Crystal Color: White Melting point (°C): 48 Flash Point (°C): 202 Specific rotation [a]20/D: -19 deg (C=2.5, CH3CN)
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