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Ace+Method+Development+Kits
Catalog Number:
(10797-474)
Supplier:
Prosci
Description:
Immunoglobulin G2 (IgG2) is a member of many immunoglobulin G developed and secreted by effective B cells. In wake of cutting by pepsin, IgG is divided into two F(ab)s with one antigen binding site and a high conserved Fc segment. The Fc segment bears a highly conserved N-glycosylation site. There are two members of IgG2: IgG2a and IgG2b. It was found that IgG2a was superior to IgG1 in activating complement. The glycosylation of the circulating immunoglobulin-? (IgG) antibody molecules changes in rheumatoid arthritis. Ig gamma-2 chain Fc region contains two constant regions of IgG2 H chain (CH2, CH3).
Catalog Number:
(10458-366)
Supplier:
Bioss
Description:
DEAD-box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp, are putative RNA helicases implicated in several cellular processes involving modifications of RNA secondary structure and ribosome/spliceosome assembly. Based on their distribution patterns, some members of this family may be involved in embryogenesis, spermatogenesis, and cellular growth and division. DDX32 is a 743 amino acid nuclear protein that localizes to the mitochondria and is a member of the DEAD box helicase family. Expressed in various tissues, DDX32 is up-regulated by ionomycin in T lymphocytes and down-regulated in acute lymphoblastic leukemia. Considered a novel RNA helicase, DDX32 may play an important role in the development of colorectal cancer and may be involved in regulating T-cell response to certain apoptotic stimuli.
Catalog Number:
(10337-122)
Supplier:
Bioss
Description:
Component of the beta-catenin destruction complex required for regulating CTNNB1 levels through phosphorylation and ubiquitination, and modulating Wnt-signaling. Controls dorsoventral patterning via two opposing effects; down-regulates CTNNB1 to inhibit the Wnt signaling pathway and ventralize embryos, but also dorsalizes embryos by activating a Wnt-independent JNK signaling pathway. In Wnt signaling, probably facilitates the phosphorylation of CTNNB1 and APC by GSK3B. Likely to function as a tumor suppressor. Facilitates the phosphorylation of TP53 by HIPK2 upon ultraviolet irradiation. Enhances TGF-beta signaling by recruiting the RNF111 E3 ubiquitin ligase and promoting the degradation of inhibitory SMAD7. Also component of the AXIN1-HIPK2-TP53 complex which controls cell growth, apoptosis and development.
Catalog Number:
(10458-374)
Supplier:
Bioss
Description:
DEAD-box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp, are putative RNA helicases implicated in several cellular processes involving modifications of RNA secondary structure and ribosome/spliceosome assembly. Based on their distribution patterns, some members of this family may be involved in embryogenesis, spermatogenesis, and cellular growth and division. DDX32 is a 743 amino acid nuclear protein that localizes to the mitochondria and is a member of the DEAD box helicase family. Expressed in various tissues, DDX32 is up-regulated by ionomycin in T lymphocytes and down-regulated in acute lymphoblastic leukemia. Considered a novel RNA helicase, DDX32 may play an important role in the development of colorectal cancer and may be involved in regulating T-cell response to certain apoptotic stimuli.
Catalog Number:
(103360-828)
Supplier:
Novus Biologicals
Description:
The GRIM19 Antibody from Novus Biologicals is a rabbit polyclonal antibody to GRIM19. This antibody reacts with human. The GRIM19 Antibody has been validated for the following applications: Western Blot, Immunohistochemistry-Paraffin.
Catalog Number:
(10749-434)
Supplier:
Prosci
Description:
BCMA Antibody: Members in the TNF superfamily regulate immune responses and induce apoptosis. Two novel members in the TNF family were recently identified and designated BAFF/BLyS/TALL-1/THANK/zTNF4 and April/TALL-2, respectively. BAFF was characterized as a B cell activator since it induced B cell proliferation and immunoglobulin secretion. April regulates immunological and non-immunological cell growth. Three receptors, BCMA (for B cell maturation protein), TACI, and BAFF-R, for BAFF were recently identified. BCMA, like TACI, binds BAFF and April. BAFF and its receptors induce B cell development and survival, activate NF-kappa B and c-jun N-terminal kinase, and are involved in B cell associated autoimmune diseases.
Supplier:
AVANTOR PERFORMANCE MATERIAL LLC
Description:
Crystals. Lot analysis on label.
Catalog Number:
(CA10817-644)
Supplier:
Biolegend
Description:
BG-2, Monoclonal Antibody, Clone: T36, Host: Mouse, Species Reactivity: Human, Immunogen: developed against the HT-29 colon cancer cell line. It is specific for Blood Group A, Isotype: IgG3, Application: Immunohistochemistry Size: 1 ml
Catalog Number:
(10101-208)
Supplier:
Prosci
Description:
This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member is one of the beta subunits, which are auxiliary proteins associating with functional Kv-alpha subunits. This member alters functional properties of the KCNA4 gene product.
Catalog Number:
(CA610-106-121)
Supplier:
Rockland Immunochemical
Description:
Conjugated Secondary Antibodies are ideal for western blotting, immunochemistry and ELISA as well as other antibody detection methods.
Supplier:
Tonbo Biosciences
Description:
The 53-6.7 antibody reacts with the 32-34 kDa alpha subunit of mouse CD8, known as CD8a or CD8 alpha. CD8a can form a homodimer (CD8 alpha-alpha), but is more commonly expressed as a heterodimer with a second chain known as CD8b or CD8 beta. CD8 acts as a co-receptor in antigen recognition and subsequent T cell activation that is initiated upon binding of the T cell receptor (TCR) to antigen-bearing MHC Class I molecules. The cytoplasmic domains of CD8 provide binding sites for the tyrosine kinase lck, facilitating intracellular signaling events that lead to T cell activation, development, and cytotoxic effector functions. CD8+ cytotoxic T cells (CTLs) play an important role in inducing cell death of tumor cells, as well as cells infected by virus, bacteria or parasites.
Catalog Number:
(10370-192)
Supplier:
Bioss
Description:
Protein Kinase c alpha (PKC alpha) is an 77 kDa member of the conventional group (cPKCs: sensitive to calcium, diacylglycerol, phosphatidylserine and phorbol esters) of the PKC family of serine/ threonine kinases that are involved in a wide range of physiological processes including mitogenesis, cell survival and transcriptional regulation. PKC alpha is an ubiquitously expressed PKC isozyme that has been implicated in the regulation of a broad range of cellular functions including proliferation, differentiation, development, migration, cell cell adhesion, cell extracellular matrix adhesion, and solute transport. The activation loop threonine (threonine 497 in PKC alpha) of conventional PKCs is phosphorylated by phosphoinositide dependent kinase 1 (PDK1). This phosphorylation is necessary for the autophosphorylation of threonine 638 in the carboxy terminus of PKC alpha, a step that is critical for regulating the rate of PKC alpha dephosphorylation and inactivation.
Supplier:
LIFE TECHNOLOGIES CORP CA
Description:
Protein A Agarose is a standard-capacity Protein A beaded agarose resin for use in a variety of antibody affinity purification methods.
Supplier:
Biolegend
Description:
?lpha-Synuclein, Monoclonal Antibody, Purified, Clone: 4D6, Host: Mouse, Species Reactivity: Human, Mouse, Rat, Immunogen: developed using a purified, E. Coli produced human A-synuclein, Isotype: IgG1, Synonym: Synuclein alpha-140, Application: ELISA, WB, Size: 500 ul
Supplier:
Bachem Americas
Description:
For the long-acting GLP-1 analog liraglutide see H-6724.
Catalog Number:
(89051-340)
Supplier:
Ace Glass
Description:
The top side arm of this Claisen adapter has a #7 Ace-Thred for use with a nylon bushing for an adjustable length thermometer.
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