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Ace+Method+Development+Kits
Catalog Number:
(10085-978)
Supplier:
Proteintech
Description:
The FXYD family is a group of small single-span transmembrane proteins characterized by a signature sequence containing an FXYD motif, two conserved glycines and a serine residue. Members of the FXYD family, including FXYD1 (phospholemman), FXYD2 (gamma subunit of Na,K-ATPase), FXYD3 (Mat8), FXYD4 (CHIF), FXYD5 (RIC), FXYD6 (phosphohippolin) and FXYD7, are tissue specific regulators of the Na,K-ATPase. FXYD6 is primarily expressed in the brain. It modulates the kinetic activity of Na,K-ATPase and has long-term physiological importance in maintaining cation homeostasis. It may play a role in endolymph composition, and has a potential important role in neuronal excitability of the CNS during postnatal development and in the adult brain. On the SDS-PAGE FXYD6 migrates with an apparent molecular weight of approximately 20 kDa, which is larger than the calculated molecular weight of 10.5 kDa . The gene encodes FXYD6 is located on chromosome 11q23.3, and it might be a susceptibility gene of schizophrenia.
Catalog Number:
(10480-406)
Supplier:
Bioss
Description:
Probable transcriptional regulator involved in developmental processes. Is required for normal development of the pharyngeal arch arteries.Involvement in disease:Haploinsufficiency of the TBX1 gene is responsible for most of the physical malformations present in DiGeorge syndrome (DGS) and velocardiofacial syndrome (VCFS) . DGS is characterized by the association of several malformations: hypoplastic thymus and parathyroid glands, congenital conotruncal cardiopathy, and a subtle but characteristic facial dysmorphology. VCFS is marked by the association of congenital conotruncal heart defects, cleft palate or velar insufficiency, facial dysmorpholgy and learning difficulties. It is now accepted that these two syndromes represent two forms of clinical expression of the same entity manifesting at different stages of life.Defects in TBX1 are a cause of DiGeorge syndrome (DGS) .Defects in TBX1 are a cause of velocardiofacial syndrome (VCFS) .Defects in TBX1 are a cause of conotruncal heart malformations (CTHM). CTHM consist of cardiac outflow tract defects, such as tetralogy of Fallot, pulmonary atresia, double-outlet right ventricle, truncus arteriosus communis, and aortic arch anomalies.
Catalog Number:
(10386-772)
Supplier:
Bioss
Description:
P73 protein is a structural and functional homologue of p53, a tumor suppressor gene. In this study, The p73 protein, p19ras, by the yeast two-hybrid screening method. Alternative splicing of the proto-oncogene H-ras pre-mRNA has led to two distinct transcripts, Ras proteins are known to be small membrane-localized guanine nucleotide-binding proteins. However, unlike other Ras proteins, p19ras is localized in the nucleus and the cytosol and its interaction with P73 protein occurred exclusively in the nucleus. Oncogenic MDM2 (mouse double minutes 2) is a known repressor of p73 transcriptional activity. In this study, when p19ras was bound to MDM2, it further inhibited the association of MDM2 to the p73 protein. Therefore, this study presents a novel pathway of Ras signaling that occurs in the nucleus, involving p19ras and p73.
Catalog Number:
(10073-194)
Supplier:
Prosci
Description:
Brutons tyrosine kinase (BTK) is a member of the BTK/Tec family of cytoplasmic tyrosine kinases.All members of the family contain SH3 and SH2 domains and, with the exception of Txk and Dsrc28C, also contain a pleckstrin homology (PH) and a Tec homology (TH) domain in their amino termini.BTK plays an important role in B cell development. Activation of B cells by various ligands is accompanied by BTK membrane translocation mediated by its PH domain binding to phosphatidylinositol-3,4,5-trisphosphate. The membrane located BTK is active and associated with transient phosphorylation of two tyrosine residues, Tyr551 and Tyr223. Tyr551 in the activation loop is transphosphorylated by the Src family tyrosine kinase, leading to autophosphorylation at Tyr223 within the SH3 domain, which is necessary for full activation.
Catalog Number:
(10101-512)
Supplier:
Prosci
Description:
TRIT1 is responsible for the modification of A37 to isopentenyl A37 of both cytosolic and mitochondrial tRNAs.
Catalog Number:
(10105-036)
Supplier:
Prosci
Description:
CNOT2 is one of the subunits of the CCR4-NOT complex,which functions as general transcription regulation complex.
Catalog Number:
(10110-822)
Supplier:
Prosci
Description:
FUNDC1 belongs to the FUN14 family. The exact function of FUNDC1 remains unknown.
Supplier:
Thermo Scientific Chemicals
Description:
Lithium perchlorate trihydrate is used as an oxygen source for chemical oxygen generators as it liberates oxygen at high temperatures. Excellent solubility of lithium perchlorate permits its use in diels-alder reactions.
Catalog Number:
(10104-106)
Supplier:
Prosci
Description:
LYPD6 contains 1 UPAR/Ly6 domain. The exact function of LYPD6 is not known.
Catalog Number:
(10105-132)
Supplier:
Prosci
Description:
Zinc Finger Protein 365 Isoform B (ZNF365) is a new candidate transcription factor.
Catalog Number:
(10101-336)
Supplier:
Prosci
Description:
Located on chromosome 3, the ZNF660 gene encodes for zinc finger protein 660.
Catalog Number:
(10102-672)
Supplier:
Prosci
Description:
TJAP1 interacts with DLG1. The exact function of TJAP1 remains unknown.
Catalog Number:
(10106-224)
Supplier:
Prosci
Description:
CITED2 belongs to the CITED family. It interferes with the binding of transcription factors HIF-1a and STAT2 to p300/CBP.
Catalog Number:
(10109-218)
Supplier:
Prosci
Description:
SLC25A39 is a member of the solute carrier family 25 and is known to transport molecules over the mitochondrial membrane.
Supplier:
Thermo Scientific Chemicals
Description:
Stripping tin coating from steel surfaces, in organic synthesis, as catalyst, in making other antimony salts, in chemical microscopy for drug identification
Supplier:
Ace Glass
Description:
Used for Microscale vacuum distillations, especially for use with a spinning band microdistillation column.
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