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Ace+Method+Development+Kits
Catalog Number:
(10108-712)
Supplier:
Prosci
Description:
KRT8 together with KRT19, help to link the contractile apparatus to dystrophin at the costameres of striated muscle.
Catalog Number:
(10106-722)
Supplier:
Prosci
Description:
Pycard is a cytosolic soluble protein that forms insoluble aggregates and enhances etoposide-induced apoptosis.
Catalog Number:
(77440-166)
Supplier:
Bioss
Description:
The protein encoded by this gene is a member of the PAK family of Ser/Thr protein kinases. PAK family members are known to be effectors of Rac/Cdc42 GTPases, which have been implicated in the regulation of cytoskeletal dynamics, proliferation, and cell survival signaling. This kinase contains a CDC42/Rac1 interactive binding (CRIB) motif, and has been shown to bind CDC42 in the presence of GTP. This kinase is predominantly expressed in brain. It is capable of promoting neurite outgrowth, and thus may play a role in neurite development. This kinase is associated with microtubule networks and induces microtubule stabilization. The subcellular localization of this kinase is tightly regulated during cell cycle progression. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq, Jul 2008]
Catalog Number:
(10095-782)
Supplier:
Proteintech
Description:
TNR, also named as Restrictin and Janusin, belongs to the tenascin family. Neural extracellular matrix (ECM) protein involved in interactions with different cells and matrix components. These interactions can influence cellular behavior by either evoking a stable adhesion and differentiation, or repulsion and inhibition of neurite growth. Binding to cell surface gangliosides, TNR inhibits RGD-dependent integrin-mediated cell adhesion and results in an inhibition of PTK2 (FAK) phosphorylation and cell detachment. Binding to membrane surface sulfatides, TNR results in a oligodendrocyte adhesion and differentiation. Interaction with CNTN1, TNR induces a repulsion of neurons and an inhibition of neurite outgrowth. Interacts with SCN2B, TNR may play a crucial role in clustering and regulation of activity of sodium channels at nodes of Ranvier. TNR-linked chondroitin sulfate glycosaminoglycans are involved in the interaction with FN1 and mediate inhibition of cell adhesion and neurite outgrowth. The highly regulated addition of sulfated carbohydrate structure may modulate the adhesive properties of TNR over the course of development and during synapse maintenance. The antibody is specific to TNR.
Supplier:
Biotium
Description:
This antibody recognizes a protein of 80 kDa-90 kDa, identified as CD36. It is expressed on platelets, monocytes and macrophages, microvascular endothelial cells, erythrocyte precursors, mammary epithelial cells, and some macrophage derived dendritic cells. CD36 acts as a receptor for thrombospondin (TSP), collagen types I, IV and V, P. falciparum malaria-infected erythrocytes, and sickle erythrocytes. It also functions as a scavenger receptor, mediating macrophage uptake of oxidized low-density lipoprotein (LDL) and recognition of apoptotic polymorphonuclear leukocytes (PMN). CD36 plays a role in platelet aggregation, macrophage foam cell development, inflammation, and the tissue ischemia observed in sickle cell disease and cerebral malaria. Note that 1-4% of Japanese and East Asia population lack CD36.
CF® dyes are Biotium's next-generation fluorescent dyes. CF®488A is a green fluorescent dye (Ex/Em 490/515 nm) with excellent brightness and photostability. The dye is minimally charged for less non-specific binding. CF®488A also is compatible with super-resolution imaging by TIRF.
Catalog Number:
(10104-094)
Supplier:
Prosci
Description:
THAP5 contains 1 THAP-type zinc finger. The exact function of THAP5 remains unknown.
Catalog Number:
(CA90003-966)
Supplier:
BD
Description:
Mueller Hinton Broth is a general-purpose medium that may be used in the cultivation of a wide variety of fastidious and nonfastidious microorganisms.
Supplier:
SPEX CERTIPREP LLC
Description:
CLP Standards for ICP & ICP-MS
Our Contract Laboratory Program (CLP) standards allow you to Calibrate with Confidence®. The standards are to be used in conjunction with the Statement of Work for Inorganic Analysis; Multi-Media/Multi-Concentration Document Number ILM 05.3/ISM 01.2. The final ICP check, performed in our own laboratories, is your stamp of assurance. We calibrate our instruments with traceable reference materials and show you the actual found value of the solution you receive, not just an ideal, calculated number as so many other standards manufacturers do. The combination of elements, concentrations and matrices listed have been diagnosed by SPEX CertiPrep for convenience of use and stability. US EPA SOW ILM 05.3/ISM 01.2 gives specific procedures for the methods of analysis, target elements, and concentrationlevels. Standards are specified not only by the elements present and their relative concentrations, but also the order and frequency of running standards, blanks and samples. Details of these specifications may be found in the US EPA SOW ILM 05.3/ISM 01.2 in the following sections: • Exhibit C, Inorganic Target Analyte List (TAL) • Exhibit D, Analytical Methods • Exhibit E, QA/QC Requirements CLP ISM 01.2 & ILM 05.3 Standards for ICP For ILM 05.3, a standard must be run at the Contract Required Detection Limits (CRDL). To verify linearity near the CRQL, this standard is analyzed at the beginning of the analysis run, after the ICV/ICB and before the ICSA and ICSAB. In addition, this standard must be run at a frequency of not less than 20 analytical samples and at the end of the analysis run, followed by the ICSA/ISCAB. The sequence order is CCV, CCB, CRI, ICSA, ICSAB, CCV, and CCB. For ISM 01.2, at least one of your calibration standards must be at the Contract Required Detection Limit (CRDL). This standard, when diluted, can be used as a calibration standard to fulfill this requirement.
Catalog Number:
(CA89067-442)
Supplier:
Bio-Serv
Description:
Nutritionally complete, soft diet with higher protein and fat levels to comply with NRC and Transgenic-users' recommendations
Supplier:
PeproTech, Inc.
Description:
Bone morphogenetic proteins (BMPs) constitute a subfamily within the TGF-β superfamily of structurally related signaling proteins. Members of this superfamily are widely distributed throughout the body and are involved in diverse physiological processes during both pre- and postnatal life. BMP-10 plays a crucial role in the development of the embryonic heart by acting to stimulate and maintain cardiomyocyte proliferation. It can signal through various receptor complexes usually containing BMPR-1A, BMPR-1B, ALK1, ALK3, or ALK6. The interaction of BMP-10 with its specific receptors can induce signaling initiated by the phosphorylation of SMAD transcription factors, including SMAD1, SMAD5, or SMAD8, but can also induce SMAD independent processes. BMP-10 is structurally related to BMP-9, and both can inhibit endothelial cell proliferation and migration. Recombinant Human BMP-10 is a 24.4 kDa homodimeric disulfide-linked protein consisting of two 108 amino acid subunits, which correspond to amino acid residues 317 to 424 of the full-length BMP-10 precursor.
Catalog Number:
(10797-940)
Supplier:
Prosci
Description:
The very-low-density-lipoprotein receptor (VLDL-R) is a lipoprotein receptor that shows considerable similarity to the lowdensity-lipoprotein receptor. VLDL R is a 130 kDa type I transmembrane protein in the LDL receptor family that plays a significant role in lipid metabolism and in nervous system development and function .This receptor has been suggested to be important for the metabolism of apoprotein-E-containing triacylglycerol-rich lipoproteins, such as very-low-densitylipoprotein (VLDL), beta-migrating VLDL and intermediate-density lipoprotein. It is also one of the receptors of reelin, an extracellular matrix protein which regulates the processes of neuronal migration and synaptic plasticity. In humans, the VLDL-R is encoded by the VLDLR gene.
A rare neurological disorder first described in the 1970s under the name "disequilibrium syndrome" is now considered to be caused by the disruption of VLDLR gene. The disorder was renamed VLDLR-associated cerebellar hypoplasia (VLDLRCH) after a 2005 study. It is associated with parental consanguinity and found in secluded communities such as the Hutterites. VLDLRCH is one of the two known genetic disorders caused by a disruption of reelin signaling pathway, along with Norman-Roberts syndrome.
Catalog Number:
(10104-116)
Supplier:
Prosci
Description:
LRRC23 contains 5 LRR (leucine-rich) repeats. The exact function of LRRC23 remains unknown.
Catalog Number:
(10102-330)
Supplier:
Prosci
Description:
KIAA0020 contains 6 pumilio repeats and 1PUM-HD domain. The function remains unknown.
Catalog Number:
(10104-318)
Supplier:
Prosci
Description:
VGLL3 belongs to the vestigial family. It may act as a specific coactivator for the mammalian TEFs.
Catalog Number:
(10106-672)
Supplier:
Prosci
Description:
Stat5 is a member of the STAT family. It mediates signaling of many cytokines and growth factors
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