Ace+Method+Development+Kits
Supplier:
Thermo Scientific Chemicals
Description:
MDL: MFCD00015570
Beilstein Registry No.: 1720987
Catalog Number:
(10110-218)
Supplier:
Prosci
Description:
CHST14 belongs to the sulfotransferase 2 family. CHST14 catalyzes the transfer of sulfate to position 4 of the N-acetylgalactosamine (GalNAc) residue of dermatan sulfate. It transfers sulfate to the C-4 hydroxyl of beta1,4-linked GalNAc that is substituted with an alpha-linked iduronic acid (IdoUA) at the C-3 hydroxyl. It transfers sulfate more efficiently to GalNAc residues in -IdoUA-GalNAc-IdoUA- than in -GlcUA-GalNAc-GlcUA-sequences. CHST14 has preference for partially desulfated dermatan sulfate. Addition of sulfate to GalNAc may occur immediately after epimerization of GlcUA to IdoUA.
Catalog Number:
(CAPIPA5-18678)
Supplier:
Thermo Scientific
Description:
This antibody has been successfully tested in a Sandwhich ELISA as both a capture and a detection antibody in combination with PA5-18406. Expression of NANOG is required for the maintenance of pluripotency in epiblast and embryonic stem (ES) cells as well as for the ability to maintain ES self-renewal independently of LIF/Stat3. The role of NANOG in embryonic development suggested that it might be useful in the creation of stem cells that might be useful in cell replacement therapies in the treatment of several degenerative diseases. Artificial stem cells, termed induced pluripotent stem (iPS) cells, can be created by expressing POU5F1 (also known as Oct-4), another germline-specific transcription factor, and the transcription factors Sox2, Klf4 and Lin28 along with c-Myc in mouse fibroblasts. More recently, experiments have demonstrated that iPS cells could be generated using expression plasmids expressing NANOG, Sox2, KlfF4 and c-Myc, eliminating the need for virus introduction, thereby addressing a safety concern for potential use of iPS cells in regenerative medicine.
Catalog Number:
(CAAAAL16225-06)
Supplier:
Thermo Scientific Chemicals
Description:
5-Amino-2-nitrobenzoic acid 95%
Catalog Number:
(10102-622)
Supplier:
Prosci
Description:
GTP-binding proteins, or G proteins, constitute a superfamily capable of binding GTP or GDP. G proteins are activated by binding GTP and are inactivated by hydrolyzing GTP to GDP. This general mechanism enables G proteins to perform a wide range of biologic activities. GTP-binding proteins, or G proteins, constitute a superfamily capable of binding GTP or GDP. G proteins are activated by binding GTP and are inactivated by hydrolyzing GTP to GDP. This general mechanism enables G proteins to perform a wide range of biologic activities.
Catalog Number:
(10108-626)
Supplier:
Prosci
Description:
OTC is a mitochondrial matrix enzyme. Missense, nonsense, and frameshift mutations in this enzyme lead to ornithine transcarbamylase deficiency, which causes hyperammonemia. Since the gene for this enzyme maps close to that for Duchenne muscular dystrophy, it may play a role in that disease also.This nuclear gene encodes a mitochondrial matrix enzyme. Missense, nonsense, and frameshift mutations in this enzyme lead to ornithine transcarbamylase deficiency, which causes hyperammonemia. Since the gene for this enzyme maps close to that for Duchenne muscular dystrophy, it may play a role in that disease also.
Supplier:
Ace Glass
Description:
Standard hypodermic stainless steel needles with 12° regular medical point tip and female Luer-Lok hub
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Catalog Number:
(CA80090-570)
Supplier:
VWR
Description:
TLS PC Link power suppy and battery charger.
Catalog Number:
(CAAAAL10400-14)
Catalog Number:
(10104-098)
Supplier:
Prosci
Description:
The Rho family of small GTPases act as molecular switches to control a wide range of cellular processes. Guanine nucleotide exchange factors (GEFs), like GEFT, activate Rho GTPases by accelerating GDP/GTP exchange.The Rho family of small GTPases act as molecular switches to control a wide range of cellular processes. Guanine nucleotide exchange factors (GEFs), like GEFT, activate Rho GTPases by accelerating GDP/GTP exchange (Souchet et al., 2002 [PubMed 11861769]).
Catalog Number:
(CA105-4101)
Supplier:
Rockland Immunochemical
Description:
Anti-goat serum antibody is suitable for western blotting, IP and for ELISA. Researchers should determine optimal titers for applications that are not stated below.
Catalog Number:
(CA101-4101)
Supplier:
Rockland Immunochemical
Description:
Anti-Bovine serum antibody is suitable for western blotting, IP and for ELISA. Researchers should determine optimal titers for applications that are not stated below.
Supplier:
Upchurch Scientific
Description:
Upchurch Scientific® seamless, precut, stainless steel tubing is designed to meet the exacting requirements of today's analyses.
Supplier:
Stemcell Technologies
Description:
Interleukin 21 (IL-21) is a pleiotropic cytokine that is composed of four α-helical bundles and primarily produced by natural killer T (NKT) cells, T follicular helper (Tfh) cells, and Th17 cells (Spolski and Leonard 2008). IL-21 signals via receptor heterodimerization of IL-21 receptor and IL-2 receptor subunit gamma (IL-2RG or CD132), both of which have a common gamma-chain subunit and activate the JAK/STAT, MAPK, and PI3K pathways (Parrish-Novak <i>et al.</i>; Ozaki <i>et al.</i> 2000; Spolski and Leonard 2014). IL-21 has been shown to have a critical role in regulating immunoglobulin production and differentiation of the pro-inflammatory Th17 population of cells (Ozaki <i>et al.</i> 2002; Nurieva <i>et al.</i>). Additionally, IL-21 specifically sustains CD8+ T cell effector activity and provides a mechanism of CD4+ T cell help during chronic viral infection (Elsaesser <i>et al.</i>). IL-21 signaling was also found critical for the development of type 1 diabetes in non-obese diabetic (NOD) mice (Sutherland <i>et al.</i>) and control of T cell autoimmunity by regulatory B cells (Yoshizaki <i>et al.</i>).
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