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Ace+Method+Development+Kits
Catalog Number:
(76082-076)
Supplier:
Bioss
Description:
Non-receptor protein-tyrosine kinase that plays an essential role in regulating cell migration, adhesion, spreading, reorganization of the actin cytoskeleton, formation and disassembly of focal adhesions and cell protrusions, cell cycle progression, cell proliferation and apoptosis. Required for early embryonic development and placenta development. Required for embryonic angiogenesis, normal cardiomyocyte migration and proliferation, and normal heart development. Regulates axon growth and neuronal cell migration, axon branching and synapse formation; required for normal development of the nervous system. Plays a role in osteogenesis and differentiation of osteoblasts. Functions in integrin signal transduction, but also in signaling downstream of numerous growth factor receptors, G-protein coupled receptors (GPCR), EPHA2, netrin receptors and LDL receptors. Forms multisubunit signaling complexes with SRC and SRC family members upon activation; this leads to the phosphorylation of additional tyrosine residues, creating binding sites for scaffold proteins, effectors and substrates. Regulates numerous signaling pathways. Promotes activation of phosphatidylinositol 3-kinase and the AKT1 signaling cascade. Promotes activation of MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling cascade. Promotes localized and transient activation of guanine nucleotide exchange factors (GEFs) and GTPase-activating proteins (GAPs), and thereby modulates the activity of Rho family GTPases. Signaling via CAS family members mediates activation of RAC1. Recruits the ubiquitin ligase MDM2 to P53/TP53 in the nucleus, and thereby regulates P53/TP53 activity, P53/TP53 ubiquitination and proteasomal degradation. Phosphorylates SRC; this increases SRC kinase activity. Phosphorylates ACTN1, ARHGEF7, GRB7, RET and WASL.
Supplier:
TCI America
Description:
CAS Number: 55849-30-4
MDL Number: MFCD00234311 Molecular Formula: C7H8BrNO Molecular Weight: 202.05 Purity/Analysis Method: >98.0% (GC,T) Form: Crystal Boiling point (°C): 107 Melting point (°C): 37 Flash Point (°C): 103
Catalog Number:
(TCC1272-010G)
Supplier:
TCI America
Description:
CAS Number: 1596-13-0
MDL Number: MFCD00142903 Molecular Formula: C13H18O Molecular Weight: 190.29 Purity/Analysis Method: >97.0% (GC) Form: Crystal Boiling point (°C): 135 Melting point (°C): 68 Flash Point (°C): 168
Catalog Number:
(10374-490)
Supplier:
Bioss
Description:
Myt1 is a zinc finger protein that is known to interact with the co-repressor Sin3B and also HDAC1 and HDAC2. The Myt1 family, including Myt1 and Myt1L, exemplifies a class of neural sequence specific transcription factors that actively recruit HDACs to selected genes during CNS development.
Catalog Number:
(10387-346)
Supplier:
Bioss
Description:
Claudin 6 is a multipass transmembrane protein in the Claudin family. Claudin 6 is expressed by epithelial cells where it participates in tissue development and the maintenance of tight junction integrity. Claudin 6 is also a global marker of definitive endoderm. Directly interacts with TJP1/ZO-1, TJP2/ZO-2 and TJP3/ZO-3.
Catalog Number:
(10387-348)
Supplier:
Bioss
Description:
Claudin 6 is a multipass transmembrane protein in the Claudin family. Claudin 6 is expressed by epithelial cells where it participates in tissue development and the maintenance of tight junction integrity. Claudin 6 is also a global marker of definitive endoderm. Directly interacts with TJP1/ZO-1, TJP2/ZO-2 and TJP3/ZO-3.
Catalog Number:
(TCC1961-100MG)
Supplier:
TCI America
Description:
CAS Number: 191-07-1
MDL Number: MFCD00004134 Molecular Formula: C24H12 Molecular Weight: 300.36 Purity/Analysis Method: >98.0% (HPLC) Form: Crystal Boiling point (°C): 525 Melting point (°C): 440
Catalog Number:
(TCD4047-1G)
Supplier:
TCI America
Description:
CAS Number: 4946-22-9
MDL Number: MFCD01658123 Molecular Formula: C8H11NS Molecular Weight: 153.24 Purity/Analysis Method: >98.0% (GC,T) Form: Crystal Boiling point (°C): 260 Melting point (°C): 33
Supplier:
TCI America
Description:
CAS Number: 3780-50-5
MDL Number: MFCD00045779 Molecular Formula: C14H22O2 Molecular Weight: 222.33 Purity/Analysis Method: >98.0% (GC) Form: Crystal Boiling point (°C): 127 Melting point (°C): 60
Catalog Number:
(TCN0011-001G)
Supplier:
TCI America
Description:
CAS Number: 1655-43-2
MDL Number: MFCD00021522 Molecular Formula: C10H8O6S2 Molecular Weight: 332.25 Purity/Analysis Method: >98.0% (HPLC,T) Form: Crystal
Catalog Number:
(10396-456)
Supplier:
Bioss
Description:
Plays an important role in the normal skeletal development. May regulate the expression of other genes involved in chondrogenesis by acting as a transcription factor for these genes.
Catalog Number:
(TCT1398-100MG)
Supplier:
TCI America
Description:
CAS Number: 643-03-8
MDL Number: MFCD00191491 Molecular Formula: C6H14O6 Molecular Weight: 182.17 Purity/Analysis Method: >98.0% (HPLC) Form: Crystal Color: White Melting point (°C): 88 Specific rotation [a]20/D: 2.8 deg (C=1, H2O)
Supplier:
TCI America
Description:
CAS Number: 129607-86-9
MDL Number: MFCD00130144 Molecular Formula: C15H26S Molecular Weight: 238.43 Purity/Analysis Method: >97.0% (GC) Form: Clear Liquid Color: Colorless Boiling point (°C): 166 Specific Gravity (20/20): 0.91
Catalog Number:
(89417-524)
Supplier:
Prosci
Description:
TCTN3 Antibody: TCTN3 is a member of the Tectonic protein family, a group of evolutionarily conserved secreted and transmembrane proteins that regulate the Hedgehog (Hh)-mediated patterning of the neural tube. While the expression pattern and function of TCTN3 is not known, it is 58% similar to TCTN1. TCTN1 is expressed during embryonic development in regions that participate in Hh signaling, beginning in the gastrulation stages in the ventral node. Mice expressing mutant TCTN1 die between E13.5 and E16.5 and display holoprosencephaly, a defect associated with reduced Hh signaling, indicating the role of TCTN1 as an Hh activator. At later stages in development, TCTN1 is thought to also act as a repressor on the Hh pathway in the anterior and posterior neural tube.
Catalog Number:
(10081-204)
Supplier:
Proteintech
Description:
Cullin-RING ligases (CRLs) complexes participate in the regulation of diverse cellular processes, including cell cycle progression, transcription, signal transduction and development . Serving as the scaffold protein, cullins are crucial for the assembly of ligase complexes, which recognize and target various substrates for proteosomal degradation. Two cullin 4 (CUL4) proteins, CUL4A (87 kDa) and CUL4B(104 kDa), are two members in cullin family with 83% of identity. Mutations in human CUL4B are one of the major causes of X-linked mental retardation. Cul4b knockout mice demonstrated that CUL4B is indispensable for embryonic development in the mouse . Proteintech's CUL4B antibody 20882-1-AP can specifically recognize CUL4B.
Catalog Number:
(10433-682)
Supplier:
Bioss
Description:
Ligand for members of the frizzled family of seven transmembrane receptors. May play an important role in the development and differentiation of certain forebrain structures, notably the hippocampus.
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