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Ace+Method+Development+Kits
Supplier:
Teknova
Description:
For use in research and development.
Catalog Number:
(102980-318)
Supplier:
Adipogen
Description:
FGF-2 (Basic fibroblast growth factor) belongs to the FGF superfamily that is made up of 22 different fibroblast growth factor genes. FGF-2 and FGF-1 (acidic FGF) are unique in that they do not follow the conventional signal sequence for secretion. FGF-2 is found in five isoforms via alternative initiation of translation. Signaling of FGF-2 occurs through the high-affinity tyrosine kinase receptors FGFR1-4. FGF-2 is a potent wide-spectrum mitogen whose overexpression is associated with immortalization and unregulated cell proliferation in many tumors. FGF-2 functions in angiogenesis, cell survival, tissue repair, embryonic development and inflammation. FGF-2 is widely used to maintain the self-renewal of human embryonic stem cells (ESCs) and to induce pluripotent stem cells. FGF-2 is an established neurogenic factor for proliferation and differentiation of multipotent neural stem cells both during development and in the adult mouse brain as well.
Catalog Number:
(10464-120)
Supplier:
Bioss
Description:
Lipin 1 is a member of the Lipin family of nuclear proteins. This family contains three members: Lipin 1, Lipin 2 and Lipin 3, all of which contain a nuclear signal sequence, a highly conserved amino-terminal (NLIP) domain and a carboxy-terminal (CLIP) domain. LPIN1 (Lipin 1) is crucial for normal adipose tissue development and metabolism. LPIN1 selectively activates a subset of PGC1 alpha target pathways, including fatty acid oxidation and mitochondrial oxidative phosphorylation by inducing expression of the nuclear receptor PPARalpha. LPIN1 also inactivates the lipogenic program and suppresses circulating lipid levels. An abundance of LPIN1 promotes fat accumulation and insulin sensitivity, whereas a deficiency in LPIN1 may deter normal adipose tissue development, resulting in insulin resistance and lipodystrophy, a heterogeneous group of disorders characterized by loss of body fat, fatty liver, hypertriglyceridemia and insulin resistance.
Catalog Number:
(10412-892)
Supplier:
Bioss
Description:
Separase is a cysteine protease that is essential for mitotic progression by separating sister chromatids. Each cell must receive one chromatid of every chromosome, during mitosis. Cohesin plays an important role in cohering sister chromatids during the prophase through anaphase stages of mitosis, making certain that genomic information is replicated accurately. As the cellular division process continues, separase destroys cohesin by means of cleavage, allowing the chromatids to separate and divide with the cell. Separase activity is highly regulated. It not only cleaves cohesin at the onset of anaphase but also cleaves itself, promoting downregulation of separase after anaphase. Should a human cell become an aneuploid (one too many or too few chromatids), the embryo most likely will not survive. Should the embryo survive, it will most likely develop severe birth defects or later develop malignant cancers.
Catalog Number:
(10448-588)
Supplier:
Bioss
Description:
CGI-99 is a 244 amino acid protein that localizes to the nucleus, as well as to the cytoplasm, and belongs to the UPF0568 family. Expressed in a variety of tissues with particularly high levels in heart and skeletal muscle, CGI-99 functions as a homodimer that interacts with Ninein and is thought to regulate Ninein function. CGI-99 is overexpressed in brain tumor tissue, suggesting a role in tumor development and metastasis. The gene encoding CGI-99 maps to human chromosome 14, which houses over 700 genes and comprises nearly 3.5% of the human genome. Chromosome 14 encodes the presinilin 1 (PSEN1) gene, which is one of the three key genes associated with the development of Alzheimer's disease (AD). The SERPINA1 gene is also located on chromosome 14 and, when defective, leads to the genetic disorder ?-antitrypsin deficiency, which is characterized by severe lung complications and liver dysfunction.
Supplier:
TCI America
Description:
CAS Number: 40876-98-0
MDL Number: MFCD00035571 Molecular Formula: C8H12O5 Molecular Weight: 210.16 Purity/Analysis Method: >95.0% (T) Form: Crystal
Catalog Number:
(TCG0356-2MG)
Supplier:
TCI America
Description:
CAS Number: 872578-72-8
Molecular Formula: C22H31N3O13 Molecular Weight: 545.50 Purity/Analysis Method: >98.0% (HPLC) Form: Crystal Storage Temperature: <0°C
Catalog Number:
(TCL0028-025G)
Supplier:
TCI America
Description:
CAS Number: 328-39-2
MDL Number: MFCD00063087 Molecular Formula: C6H13NO2 Molecular Weight: 131.18 Purity/Analysis Method: >98.0% (T) Form: Crystal
Supplier:
TCI America
Description:
CAS Number: 23135-50-4
Molecular Formula: C13H17NO4 Molecular Weight: 251.28 Purity/Analysis Method: >98.0% (T) Form: Crystal Melting point (°C): 106
Supplier:
TCI America
Description:
CAS Number: 5437-33-2
Molecular Formula: C5H3Cl2NO Molecular Weight: 163.99 Purity/Analysis Method: >98.0% (GC) Form: Crystal Melting point (°C): 180
Catalog Number:
(77439-898)
Supplier:
Bioss
Description:
Ligand for members of the frizzled family of seven transmembrane receptors. Wnt-3 and Wnt-3a play distinct roles in cell-cell signaling during morphogenesis of the developing neural tube.
Supplier:
TCI America
Description:
CAS Number: 5241-64-5
MDL Number: MFCD00037944 Molecular Formula: C16H20N2O4 Molecular Weight: 304.35 Purity/Analysis Method: >98.0% (HPLC) Form: Crystal
Supplier:
TCI America
Description:
CAS Number: 126-83-0
MDL Number: MFCD00013378 Molecular Formula: C3H7ClO4S Molecular Weight: 196.58 Purity/Analysis Method: >95.0% (T) Form: Crystal
Supplier:
TCI America
Description:
CAS Number: 58917-85-4
MDL Number: MFCD00191193 Molecular Formula: C17H19NO3 Molecular Weight: 285.34 Purity/Analysis Method: >97.0% (HPLC) Form: Crystal Melting point (°C): 93 Specific rotation [a]20/D: 42 deg (C=2, MeOH)
Supplier:
TCI America
Description:
CAS Number: 51805-45-9
MDL Number: MFCD00145469 Molecular Formula: C9H15O6P Molecular Weight: 286.64 Purity/Analysis Method: >98.0% (T) Form: Crystal Color: White Melting point (°C): 177
Catalog Number:
(TCT1252-005G)
Supplier:
TCI America
Description:
CAS Number: 5813-89-8
MDL Number: MFCD00010425 Molecular Formula: C5H5NOS Molecular Weight: 127.16 Purity/Analysis Method: >98.0% (N) Form: Crystal Color: White Melting point (°C): 182
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