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Ace+Method+Development+Kits
Catalog Number:
(10750-000)
Supplier:
Prosci
Description:
TEM2 Antibody: Rhes, also known as tumor endothelial marker 2 (TEM2), is a small GTP-binding protein that is predominantly expressed in the striatal region of the brain. This protein belongs to the RASD subfamily of Ras-related GTP-binding protein superfamily and is thought to play a role in the normal development and function of the brain as mice lacking this gene showed increased anxiety levels and motor coordination deficits. Rhes was identified as TEM2 through analysis of genes whose expression was upregulated in tumor endothelium. Tumor endothelial markers are significantly up-regulated during angiogenesis and neoangiogenesis that are crucial for the growth of solid tumors. TEMs localized on the cell surface and conserved across species are of particular interest for future development of anti-angiogenic therapies.
Supplier:
TCI America
Description:
CAS Number: 21190-87-4
MDL Number: MFCD00093197 Molecular Formula: C6H4BrNO2 Molecular Weight: 202.01 Purity/Analysis Method: >98.0% (GC,T) Form: Crystal Melting point (°C): 189
Supplier:
TCI America
Description:
CAS Number: 10242-01-0
MDL Number: MFCD03265451 Molecular Formula: C10H9NO3 Molecular Weight: 191.19 Purity/Analysis Method: >98.0% (HPLC,T) Form: Crystal Melting point (°C): 173
Supplier:
TCI America
Description:
CAS Number: 7311-63-9
MDL Number: MFCD00079725 Molecular Formula: C5H3BrO2S Molecular Weight: 207.04 Purity/Analysis Method: >98.0% (GC,T) Form: Crystal Melting point (°C): 142
Catalog Number:
(TCD2757-5G)
Supplier:
TCI America
Description:
CAS Number: 905-62-4
MDL Number: MFCD00045582 Molecular Formula: C22H14N2O Molecular Weight: 322.37 Purity/Analysis Method: >98.0% (N,HPLC) Form: Crystal Melting point (°C): 179
Catalog Number:
(TCF0240-005G)
Supplier:
TCI America
Description:
CAS Number: 596-09-8
MDL Number: MFCD00005062 Molecular Formula: C24H16O7 Molecular Weight: 416.39 Purity/Analysis Method: >98.0% (HPLC) Form: Crystal Melting point (°C): 206
Supplier:
TCI America
Description:
CAS Number: 6994-25-8
MDL Number: MFCD00005238 Molecular Formula: C6H9N3O2 Molecular Weight: 155.16 Purity/Analysis Method: >98.0% (GC,T) Form: Crystal Melting point (°C): 102
Supplier:
TCI America
Description:
CAS Number: 247129-85-7
MDL Number: MFCD12546049 Molecular Formula: C15H14BrF3O3S2 Molecular Weight: 443.29 Purity/Analysis Method: >98.0% (HPLC,T) Form: Crystal Melting point (°C): 90
Supplier:
TCI America
Description:
CAS Number: 6307-82-0
MDL Number: MFCD00184587 Molecular Formula: C8H6ClNO4 Molecular Weight: 215.59 Purity/Analysis Method: >98.0% (GC) Form: Crystal Melting point (°C): 70
Supplier:
TCI America
Description:
CAS Number: 134412-17-2
MDL Number: MFCD09839000 Molecular Formula: C23H28F2 Molecular Weight: 342.47 Purity/Analysis Method: >98.0% (GC) Form: Crystal Melting point (°C): 58
Catalog Number:
(10430-774)
Supplier:
Bioss
Description:
Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters (By similarity). Overexpression may be associated with abnormal proliferation in human breast tissue.
Supplier:
TCI America
Description:
CAS Number: 5325-20-2
MDL Number: MFCD00006698 Molecular Formula: C8H7NOS Molecular Weight: 165.21 Purity/Analysis Method: >98.0% (GC) Form: Crystal Melting point (°C): 180
Supplier:
TCI America
Description:
CAS Number: 737776-93-1
MDL Number: MFCD06411336 Molecular Formula: C22H32B2FeO4 Molecular Weight: 437.96 Purity/Analysis Method: >98.0% (GC,T) Form: Crystal Melting point (°C): 173
Catalog Number:
(89417-092)
Supplier:
Prosci
Description:
MAK10 Antibody: The MAK10 gene encodes a 733-amino acid protein with several regions of similarity to T cell receptor alpha-subunit V (variable) regions in yeast. The mammalian homologue of yeast MAK10, also known as EGAP, is one subunit of a novel N-terminal acetyltransferase (NAT) that is highly conserved among vertebrate species. It is expressed in a variety of tissues in the developing rat embryo but restricted in expression in the adult, remaining detectable only in tissues undergoing continual cell renewal or in cells responding to pathological injury. The MAK10-NAT complex is an essential regulatory enzyme controlling the function of a subset of proteins required for embryonic growth control and vessel development. This complex functionally co-assembles in mammalian cells to regulate cell proliferation and is essential for embryonic development, at least in part through the regulation of target of rapamycin (TOR) signaling events. At least two isoforms of MAK10 are known to exist.
Catalog Number:
(10750-222)
Supplier:
Prosci
Description:
Nanos1 Antibody: Nanos1 is one of three known mammalian homologs to the Drosophila gene nanos. Nanos1 is an RNA-binding protein containing a zinc-finger motif and is expressed in the developing nervous system and continues in the adult brain. Interestingly, unlike mice deficient in either nanos2 or nanos3, mice lacking the nanos1 gene develop normally with no sign of abnormalities. Recently it has been found that expression of nanos1 mRNA is down-regulated by E-cadherin in a human breast cancer cell line and the amino-terminal domain on Nanos1 interacts with the E-cadherin-binding protein p120ctn. Furthermore, overexpression of Nanos1 in human colorectal DLD1 cancer cells functionally abolished cell-cell adhesion, allowing the cancer cells to develop strong migratory and invasive properties. These results suggest that targeting Nanos1 might prove an effective strategy in the treatment of E-cadherin-negative tumors.
Supplier:
Tonbo Biosciences
Description:
The 3G3 antibody reacts with mouse Foxp3, a 50-55 kDa transcription factor which is a central regulator of T cell activity and is critical for the development and function of regulatory T cells (Tregs). Foxp3 is expressed at constitutively high levels in Treg cells, which are further identified as being CD4+ CD25+. In resting conventional T cells (CD4+ CD25-) Foxp3 expression is restricted, and upon TCR activation is expressed only transiently and in a small proportion of cells. However, the growth factor TGF-beta has been shown to induce expression of Foxp3 in naïve T cells, driving their development into Foxp3+ Tregs, which are called “induced” or “adaptive” Tregs. These cells are phenotypically similar to so-called “natural” Tregs (CD4+ CD25high Foxp3+) which originate in the thymus and comprise the majority of Treg cells. Tregs are critical for maintaining peripheral tolerance and are implicated in the development of autoimmunity.
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