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Ace+Method+Development+Kits
Catalog Number:
(10450-676)
Supplier:
Bioss
Description:
Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Among GPI-anchored ephrin-A ligands, EFNA5 most probably constitutes the cognate/functional ligand for EPHA5. Functions as an axon guidance molecule during development and may be involved in the development of the retinotectal, entorhino-hippocampal and hippocamposeptal pathways. Together with EFNA5 plays also a role in synaptic plasticity in adult brain through regulation of synaptogenesis. In addition to its function in the nervous system, the interaction of EPHA5 with EFNA5 mediates communication between pancreatic islet cells to regulate glucose-stimulated insulin secretion (By similarity).
Catalog Number:
(10464-126)
Supplier:
Bioss
Description:
Lipin 1 is a member of the Lipin family of nuclear proteins. This family contains three members: Lipin 1, Lipin 2 and Lipin 3, all of which contain a nuclear signal sequence, a highly conserved amino-terminal (NLIP) domain and a carboxy-terminal (CLIP) domain. LPIN1 (Lipin 1) is crucial for normal adipose tissue development and metabolism. LPIN1 selectively activates a subset of PGC1 alpha target pathways, including fatty acid oxidation and mitochondrial oxidative phosphorylation by inducing expression of the nuclear receptor PPARalpha. LPIN1 also inactivates the lipogenic program and suppresses circulating lipid levels. An abundance of LPIN1 promotes fat accumulation and insulin sensitivity, whereas a deficiency in LPIN1 may deter normal adipose tissue development, resulting in insulin resistance and lipodystrophy, a heterogeneous group of disorders characterized by loss of body fat, fatty liver, hypertriglyceridemia and insulin resistance.
Catalog Number:
(10412-880)
Supplier:
Bioss
Description:
Separase is a cysteine protease that is essential for mitotic progression by separating sister chromatids. Each cell must receive one chromatid of every chromosome, during mitosis. Cohesin plays an important role in cohering sister chromatids during the prophase through anaphase stages of mitosis, making certain that genomic information is replicated accurately. As the cellular division process continues, separase destroys cohesin by means of cleavage, allowing the chromatids to separate and divide with the cell. Separase activity is highly regulated. It not only cleaves cohesin at the onset of anaphase but also cleaves itself, promoting downregulation of separase after anaphase. Should a human cell become an aneuploid (one too many or too few chromatids), the embryo most likely will not survive. Should the embryo survive, it will most likely develop severe birth defects or later develop malignant cancers.
Catalog Number:
(10464-116)
Supplier:
Bioss
Description:
Lipin 1 is a member of the Lipin family of nuclear proteins. This family contains three members: Lipin 1, Lipin 2 and Lipin 3, all of which contain a nuclear signal sequence, a highly conserved amino-terminal (NLIP) domain and a carboxy-terminal (CLIP) domain. LPIN1 (Lipin 1) is crucial for normal adipose tissue development and metabolism. LPIN1 selectively activates a subset of PGC1 alpha target pathways, including fatty acid oxidation and mitochondrial oxidative phosphorylation by inducing expression of the nuclear receptor PPARalpha. LPIN1 also inactivates the lipogenic program and suppresses circulating lipid levels. An abundance of LPIN1 promotes fat accumulation and insulin sensitivity, whereas a deficiency in LPIN1 may deter normal adipose tissue development, resulting in insulin resistance and lipodystrophy, a heterogeneous group of disorders characterized by loss of body fat, fatty liver, hypertriglyceridemia and insulin resistance.
Catalog Number:
(10448-590)
Supplier:
Bioss
Description:
CGI-99 is a 244 amino acid protein that localizes to the nucleus, as well as to the cytoplasm, and belongs to the UPF0568 family. Expressed in a variety of tissues with particularly high levels in heart and skeletal muscle, CGI-99 functions as a homodimer that interacts with Ninein and is thought to regulate Ninein function. CGI-99 is overexpressed in brain tumor tissue, suggesting a role in tumor development and metastasis. The gene encoding CGI-99 maps to human chromosome 14, which houses over 700 genes and comprises nearly 3.5% of the human genome. Chromosome 14 encodes the presinilin 1 (PSEN1) gene, which is one of the three key genes associated with the development of Alzheimer's disease (AD). The SERPINA1 gene is also located on chromosome 14 and, when defective, leads to the genetic disorder ?-antitrypsin deficiency, which is characterized by severe lung complications and liver dysfunction.
Supplier:
TCI America
Description:
CAS Number: 111-62-6
MDL Number: MFCD00009579 Molecular Formula: C20H38O2 Molecular Weight: 310.52 Purity/Analysis Method: >70.0% (GC) Form: Clear Liquid Boiling point (°C): 209 Flash Point (°C): 181 Specific Gravity (20/20): 0.87
Supplier:
TCI America
Description:
CAS Number: 1999-00-4
MDL Number: MFCD03093631 Molecular Formula: C11H11FO3 Molecular Weight: 210.20 Purity/Analysis Method: >98.0% (GC,T) Form: Clear Liquid Boiling point (°C): 120 Flash Point (°C): 110 Specific Gravity (20/20): 1.19
Supplier:
TCI America
Description:
CAS Number: 4733-39-5
MDL Number: MFCD00004972 Molecular Formula: C26H20N2 Molecular Weight: 360.46 Purity/Analysis Method: >99.0% (HPLC,T) Form: Crystal Melting point (°C): 283
Supplier:
TCI America
Description:
CAS Number: 73-31-4
MDL Number: MFCD00005655 Molecular Formula: C13H16N2O2 Molecular Weight: 232.28 Purity/Analysis Method: >98.0% (HPLC,N) Form: Crystal Melting point (°C): 118
Catalog Number:
(TCF0423-001G)
Supplier:
TCI America
Description:
CAS Number: 197770-48-2
MDL Number: MFCD02093472 Molecular Formula: C14H9FO Molecular Weight: 212.22 Purity/Analysis Method: >98.0% (GC) Form: Crystal Melting point (°C): 149
Catalog Number:
(TCB2137-001G)
Supplier:
TCI America
Description:
CAS Number: 16495-03-7
MDL Number: MFCD00043000 Molecular Formula: C13H18O3 Molecular Weight: 222.28 Purity/Analysis Method: >98.0% (GC) Form: Clear Liquid Flash Point (°C): 100 Specific Gravity (20/20): 1.05 Specific rotation [a]20/D: 19 deg (neat) Storage Temperature: 0-10°C
Catalog Number:
(TCC0189-025G)
Supplier:
TCI America
Description:
(stabilized with Copper chip)
CAS Number: 615-41-8 MDL Number: MFCD00001033 Molecular Formula: C6H4ClI Molecular Weight: 238.45 Purity/Analysis Method: >98.0% (GC) Form: Clear Liquid Boiling point (°C): 232 Melting point (°C): 1 Flash Point (°C): 112 Specific Gravity (20/20): 1.96
Catalog Number:
(TCH0491-500ML)
Supplier:
TCI America
Description:
[for HPLC Solvent]
CAS Number: 142-82-5 MDL Number: MFCD00009544 Molecular Formula: C7H16 Molecular Weight: 100.21 Purity/Analysis Method: >99.0% (GC) Form: Clear Liquid Boiling point (°C): 98 Melting point (°C): -91 Flash Point (°C): -2 Specific Gravity (20/20): 0.68
Supplier:
TCI America
Description:
[e.e. Determination Reagent by NMR]
CAS Number: 60646-30-2 MDL Number: MFCD00062968 Molecular Formula: C16H11F3O Molecular Weight: 276.26 Purity/Analysis Method: >99.0% (GC) Form: Crystal Color: Very Pale Yellow Melting point (°C): 135 Specific rotation [a]20/D: 30.5 deg (C=1, CHCl3)
Supplier:
TCI America
Description:
CAS Number: 1120-25-8
MDL Number: MFCD00042911 Molecular Formula: C17H32O2 Molecular Weight: 268.44 Purity/Analysis Method: >98.0% (GC) Form: Clear Liquid Color: Colorless Boiling point (°C): 126 Flash Point (°C): 113 Specific Gravity (20/20): 0.88 Storage Temperature: <0°C
Catalog Number:
(TCT1520-100MG)
Supplier:
TCI America
Description:
[e.e. Determination Reagent by NMR]
CAS Number: 53531-34-3 MDL Number: MFCD00001260 Molecular Formula: C16H11F3O Molecular Weight: 276.26 Purity/Analysis Method: >99.0% (GC) Form: Crystal Color: Slightly Pale Yellow Melting point (°C): 134 Specific rotation [a]20/D: -30.5 deg (C=1, CHCl3)
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