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Ace+Method+Development+Kits
Catalog Number:
(10460-246)
Supplier:
Bioss
Description:
Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Among GPI-anchored ephrin-A ligands, EFNA5 is a cognate/functional ligand for EPHA7 and their interaction regulates brain development modulating cell-cell adhesion and repulsion. Has a repellent activity on axons and is for instance involved in the guidance of corticothalamic axons and in the proper topographic mapping of retinal axons to the colliculus. May also regulate brain development through a caspase(CASP3)-dependent proapoptotic activity. Forward signaling may result in activation of components of the ERK signaling pathway including MAP2K1, MAP2K2, MAPK1 AND MAPK3 which are phosphorylated upon activation of EPHA7.
Catalog Number:
(10347-638)
Supplier:
Bioss
Description:
Retinoids are metabolites of vitamin A (retinal) and are believed to represent important signaling molecules during vertebrate development and tissue differentiation. Two families of retinoid receptors have been identified. Retinoic acid receptors (RARs) include RAR alpha, RAR beta and RAR gamma, each of which has a high affinity for all trans retinoic acids and belongs to the same class of nuclear transcription factors as thyroid hormone receptors, vitamin D3 receptor and ecdysone receptor. The ligand binding domains of the RARs are highly conserved and RAR isoforms are expressed in distinct patterns through out development and in the mature organism. Members of the retinoid X receptor (RXR) family, RXR alpha, RXR beta and RXR gamma, are activated by 9 cis retinoic acid, a stereo and photoisomer of all trans RA that is expressed in vivo in both liver and kidney and may represent a widely used hormone.
Catalog Number:
(10460-254)
Supplier:
Bioss
Description:
Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Among GPI-anchored ephrin-A ligands, EFNA5 is a cognate/functional ligand for EPHA7 and their interaction regulates brain development modulating cell-cell adhesion and repulsion. Has a repellent activity on axons and is for instance involved in the guidance of corticothalamic axons and in the proper topographic mapping of retinal axons to the colliculus. May also regulate brain development through a caspase(CASP3)-dependent proapoptotic activity. Forward signaling may result in activation of components of the ERK signaling pathway including MAP2K1, MAP2K2, MAPK1 AND MAPK3 which are phosphorylated upon activation of EPHA7.
Catalog Number:
(76082-878)
Supplier:
Bioss
Description:
Retinoids are metabolites of vitamin A (retinal) and are believed to represent important signaling molecules during vertebrate development and tissue differentiation. Two families of retinoid receptors have been identified. Retinoic acid receptors (RARs) include RAR alpha, RAR beta and RAR gamma, each of which has a high affinity for all trans retinoic acids and belongs to the same class of nuclear transcription factors as thyroid hormone receptors, vitamin D3 receptor and ecdysone receptor. The ligand binding domains of the RARs are highly conserved and RAR isoforms are expressed in distinct patterns through out development and in the mature organism. Members of the retinoid X receptor (RXR) family, RXR alpha, RXR beta and RXR gamma, are activated by 9 cis retinoic acid, a stereo and photoisomer of all trans RA that is expressed in vivo in both liver and kidney and may represent a widely used hormone.
Catalog Number:
(10664-766)
Supplier:
Bioss
Description:
FOXC2 is a member of forkhead/winged helix transcription factor family, whose members serve as key regulators in embryogenesis and cell differentiation (3). FOXC2 functions as a key regulator of adipocyte metabolism by increasing the sensitivity of the beta-adrenergic-cAMP-protein kinase A (PKA) signaling pathway through alteration of adipocyte PKA holoenzyme composition (4). Increased FOXC2 levels, induced by high fat diet, seem to counteract most of the symptoms associated with obesity (4). FOXC2 expression is also associated with the early stage of chondrogenic differentiation both in vivo and in vitro (3). FOXC2 haploinsufficiency results in Lymphedema-distichiasis (LD), an autosomal dominant disorder that classically presents as lymphedema of the limbs, and double rows of eyelashes (distichiasis) (5). Mutant mice null for FOXC2 show defects in axial and cranial skeletogenesis, suggesting a requirement of FOXC2 for skeletal tissue development (3). FOXC2 interacts with FOXC1 in the Notch signaling pathway (1) and in kidney and heart development (2).
Catalog Number:
(TCC1121-010G)
Supplier:
TCI America
Description:
CAS Number: 2613-23-2
MDL Number: MFCD00002257 Molecular Formula: C6H4ClFO Molecular Weight: 146.55 Purity/Analysis Method: >96.0% (GC) Form: Crystal Boiling point (°C): 104 Melting point (°C): 40 Flash Point (°C): 109
Supplier:
TCI America
Description:
CAS Number: 637-88-7
MDL Number: MFCD00001606 Molecular Formula: C6H8O2 Molecular Weight: 112.13 Purity/Analysis Method: >98.0% (GC) Form: Crystal Boiling point (°C): 132 Melting point (°C): 78 Flash Point (°C): 132
Supplier:
TCI America
Description:
CAS Number: 38557-71-0
MDL Number: MFCD00055032 Molecular Formula: C5H5ClN2 Molecular Weight: 128.56 Purity/Analysis Method: >98.0% (GC) Form: Crystal Boiling point (°C): 83 Melting point (°C): 52
Supplier:
TCI America
Description:
CAS Number: 96-30-0
MDL Number: MFCD00018913 Molecular Formula: C3H6ClNO Molecular Weight: 107.54 Purity/Analysis Method: >98.0% (GC) Form: Crystal Boiling point (°C): 116 Melting point (°C): 44
Catalog Number:
(77438-916)
Supplier:
Bioss
Description:
Functions both as protein phosphatase and as transcriptional coactivator for SIX1, and probably also for SIX2, SIX4 and SIX5. Tyrosine phosphatase that dephosphorylates 'Tyr-142' of histone H2AX (H2AXY142ph) and promotes efficient DNA repair via the recruitment of DNA repair complexes containing MDC1. 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Its function as histone phosphatase may contribute to its function in transcription regulation during organogenesis. Has also phosphatase activity with proteins phosphorylated on Ser and Thr residues (in vitro). Required for normal embryonic development of the craniofacial and trunk skeleton, kidneys and ears. Together with SIX1, it plays an important role in hypaxial muscle development; in this it is functionally redundant with EYA2.
Supplier:
TCI America
Description:
CAS Number: 22784-59-4
MDL Number: MFCD00010395 Molecular Formula: C43H37ClP2Pd Molecular Weight: 757.59 Purity/Analysis Method: >96.0% (T) Form: Crystal Storage Temperature: <0°C
Supplier:
TCI America
Description:
CAS Number: 13603-44-6
MDL Number: MFCD00956021 Molecular Formula: C7H9NO Molecular Weight: 123.16 Purity/Analysis Method: >98.0% (GC) Form: Crystal Boiling point (°C): 351 Melting point (°C): 230
Supplier:
TCI America
Description:
CAS Number: 628333-86-8
MDL Number: MFCD09038823 Molecular Formula: C29H33N2P Molecular Weight: 440.57 Purity/Analysis Method: >98.0% (GC,T) Form: Crystal Melting point (°C): 142
Supplier:
TCI America
Description:
CAS Number: 19438-10-9
MDL Number: MFCD00002295 Molecular Formula: C8H8O3 Molecular Weight: 152.15 Purity/Analysis Method: >98.0% (GC,T) Form: Crystal Boiling point (°C): 178 Melting point (°C): 73
Catalog Number:
(TCC0973-025G)
Supplier:
TCI America
Description:
CAS Number: 17849-38-6
MDL Number: MFCD00004604 Molecular Formula: C7H7ClO Molecular Weight: 142.58 Purity/Analysis Method: >98.0% (GC) Form: Crystal Boiling point (°C): 135 Melting point (°C): 71
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