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Ace+Method+Development+Kits
Supplier:
TCI America
Description:
CAS Number: 10517-44-9
MDL Number: MFCD00012525 Molecular Formula: C3H10N2 Molecular Weight: 147.04 Purity/Analysis Method: >97.0% (T) Form: Crystal Color: White Melting point (°C): 253
Supplier:
TCI America
Description:
CAS Number: 1719-83-1
MDL Number: MFCD00082228 Molecular Formula: C12H8O6 Molecular Weight: 248.19 Purity/Analysis Method: >98.0% (T) Form: Crystal
Supplier:
TCI America
Description:
CAS Number: 114772-34-8
MDL Number: MFCD03453661 Molecular Formula: C15H14O2 Molecular Weight: 226.28 Purity/Analysis Method: >98.0% (GC) Form: Crystal Melting point (°C): 59
Supplier:
TCI America
Description:
CAS Number: 15788-16-6
MDL Number: MFCD00011555 Molecular Formula: C8H6N2O2 Molecular Weight: 162.15 Purity/Analysis Method: >97.0% (T) Form: Crystal
Catalog Number:
(10798-042)
Supplier:
Prosci
Description:
CD3e molecule, epsilon is also known as CD3E, is a T-cell surface single-pass type I membrane glycoprotein. CD3E contains 1 Ig-like (immunoglobulin-like) domain and 1 ITAM domain. CD3E, together with CD3-gamma, CD3-delta and CD3-zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T cell receptor-CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The genes encoding the epsilon, gamma and delta polypeptides are located in the same cluster on chromosome 11. The epsilon polypeptide plays an essential role in T-cell development. CD3E plays an essential role in T-cell development, and defects in CD3E gene cause severe immunodeficiency. CD3E gene has also been linked to a susceptibility to type I diabetes in women. CD3E has been shown to interact with TOP2B, CD3EAP and NCK2.
Catalog Number:
(75793-892)
Supplier:
Prosci
Description:
bHLH proteins are essential for neurogenesis, myogenesis, hematopoiesis and sex determination. HES1 (Hairy and Enhancer of Split 1) is a basic Helix-Loop-Helix (bHLH) transcriptional repressor regulated by the Notch pathway and expressed in various tissues. HES1 is well known in development of different tissues, particularly endoderm derived endocrine organs like pancreas and neuroendocrine cells of lung. HES1 controls normal development by regulating proliferation and differentiation and so cell fate. Notch signaling plays both oncogenic and tumor suppressor roles depending on cell type. In contrast to T cell acute lymphoblastic leukemia (ALL), where Notch activation promotes leukemogenesis, induction of Notch signaling in B cell ALL (B-ALL) leads to growth arrest and apoptosis. The Notch target HES1 is sufficient to reproduce this tumor suppressor phenotype in B-ALL by interacting and activating PARP-1 and regulating proapoptotic signals.
Supplier:
TCI America
Description:
CAS Number: 2665-12-5
MDL Number: MFCD00059311 Molecular Formula: C21H21BO3 Molecular Weight: 332.21 Purity/Analysis Method: >98.0% (T) Form: Clear Liquid Boiling point (°C): 386 Flash Point (°C): 174 Specific Gravity (20/20): 1.09
Catalog Number:
(10448-592)
Supplier:
Bioss
Description:
CGI-99 is a 244 amino acid protein that localizes to the nucleus, as well as to the cytoplasm, and belongs to the UPF0568 family. Expressed in a variety of tissues with particularly high levels in heart and skeletal muscle, CGI-99 functions as a homodimer that interacts with Ninein and is thought to regulate Ninein function. CGI-99 is overexpressed in brain tumor tissue, suggesting a role in tumor development and metastasis. The gene encoding CGI-99 maps to human chromosome 14, which houses over 700 genes and comprises nearly 3.5% of the human genome. Chromosome 14 encodes the presinilin 1 (PSEN1) gene, which is one of the three key genes associated with the development of Alzheimer's disease (AD). The SERPINA1 gene is also located on chromosome 14 and, when defective, leads to the genetic disorder ?-antitrypsin deficiency, which is characterized by severe lung complications and liver dysfunction.
Catalog Number:
(10464-124)
Supplier:
Bioss
Description:
Lipin 1 is a member of the Lipin family of nuclear proteins. This family contains three members: Lipin 1, Lipin 2 and Lipin 3, all of which contain a nuclear signal sequence, a highly conserved amino-terminal (NLIP) domain and a carboxy-terminal (CLIP) domain. LPIN1 (Lipin 1) is crucial for normal adipose tissue development and metabolism. LPIN1 selectively activates a subset of PGC1 alpha target pathways, including fatty acid oxidation and mitochondrial oxidative phosphorylation by inducing expression of the nuclear receptor PPARalpha. LPIN1 also inactivates the lipogenic program and suppresses circulating lipid levels. An abundance of LPIN1 promotes fat accumulation and insulin sensitivity, whereas a deficiency in LPIN1 may deter normal adipose tissue development, resulting in insulin resistance and lipodystrophy, a heterogeneous group of disorders characterized by loss of body fat, fatty liver, hypertriglyceridemia and insulin resistance.
Catalog Number:
(10412-898)
Supplier:
Bioss
Description:
Separase is a cysteine protease that is essential for mitotic progression by separating sister chromatids. Each cell must receive one chromatid of every chromosome, during mitosis. Cohesin plays an important role in cohering sister chromatids during the prophase through anaphase stages of mitosis, making certain that genomic information is replicated accurately. As the cellular division process continues, separase destroys cohesin by means of cleavage, allowing the chromatids to separate and divide with the cell. Separase activity is highly regulated. It not only cleaves cohesin at the onset of anaphase but also cleaves itself, promoting downregulation of separase after anaphase. Should a human cell become an aneuploid (one too many or too few chromatids), the embryo most likely will not survive. Should the embryo survive, it will most likely develop severe birth defects or later develop malignant cancers.
Supplier:
TCI America
Description:
CAS Number: 7382-32-3
MDL Number: MFCD00518661 Molecular Formula: C9H20O3 Molecular Weight: 176.26 Purity/Analysis Method: >99.0% (GC) Form: Clear Liquid Specific Gravity (20/20): 0.91
Supplier:
TCI America
Description:
CAS Number: 6212-33-5
MDL Number: MFCD00049328 Molecular Formula: C8H8ClNO2 Molecular Weight: 185.61 Purity/Analysis Method: >98.0% (T) Form: Crystal
Supplier:
TCI America
Description:
CAS Number: 99-20-7
MDL Number: MFCD00006628 Molecular Formula: C12H22O11 Molecular Weight: 342.30 Purity/Analysis Method: >98.0% (GC) Form: Crystal Color: White Melting point (°C): 205 Specific rotation [a]20/D: 197 deg (C=7, H2O)
Supplier:
TCI America
Description:
CAS Number: 142063-30-7
MDL Number: MFCD00041883 Molecular Formula: C8H10O3S Molecular Weight: 208.21 Purity/Analysis Method: >98.0% (T) Form: Crystal
Supplier:
TCI America
Description:
(stabilized with MEHQ)
CAS Number: 3098-92-8 MDL Number: MFCD00059324 Molecular Formula: C11H10O2 Molecular Weight: 174.20 Purity/Analysis Method: >99.0% (GC) Form: Clear Liquid Boiling point (°C): 125 Melting point (°C): -28 Flash Point (°C): 132 Specific Gravity (20/20): 1.07
Supplier:
TCI America
Description:
CAS Number: 53562-86-0
MDL Number: MFCD00064461 Molecular Formula: C5H10O3 Molecular Weight: 118.13 Purity/Analysis Method: >98.0% (GC) Form: Clear Liquid Boiling point (°C): 76 Flash Point (°C): 73 Specific Gravity (20/20): 1.06 Specific rotation [a]20/D: 22.5 deg (neat)
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