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Isolation+and+Cleanup+HyClone+products+(Cytiva)
Supplier:
Honeywell Safety Products
Description:
For use with North Safety Products airline hood and full facepiece respirators.
Catalog Number:
(10369-422)
Supplier:
Bioss
Description:
Required for lipopolysaccharide (LPS)-induced, TLR4-mediated activation of the MAPK/ERK pathway in macrophages, thus being critical for production of the proinflammatory cytokine TNF-alpha (TNF) during immune responses. Involved in the regulation of T-helper cell differentiation and IFNG expression in T-cells. Involved in mediating host resistance to bacterial infection through negative regulation of type I interferon (IFN) production. In vitro, activates MAPK/ERK pathway in response to IL1 in an IRAK1-independent manner, leading to up-regulation of IL8 and CCL4. Transduces CD40 and TNFRSF1A signals that activate ERK in B-cells and macrophages, and thus may play a role in the regulation of immunoglobulin production. May also play a role in the transduction of TNF signals that activate JNK and NF-kappa-B in some cell types. In adipocytes, activates MAPK/ERK pathway in an IKBKB-dependent manner in response to IL1B and TNF, but not insulin, leading to induction of lipolysis. Plays a role in the cell cycle. Isoform 1 shows some transforming activity, although it is much weaker than that of the activated oncogenic variant.
Supplier:
Ansell Healthcare
Description:
First ergonomically certified chemical glove. Maximize worker productivity by minimizing hand fatigue.
Catalog Number:
(76082-528)
Supplier:
Bioss
Description:
Cytokine with immunoregulatory activity. May promote the transition between innate and adaptive immunity. Induces the production of IgG(1) and IgG(3) in B-cells (By similarity). May play a role in proliferation and maturation of natural killer (NK) cells in synergy with IL15. May regulate proliferation of mature B- and T-cells in response to activating stimuli. In synergy with IL15 and IL18 stimulates interferon gamma production in T-cells and NK cells. During T-cell mediated immune response may inhibit dendritic cells (DC) activation and maturation.
Supplier:
Shenandoah Biotechnology
Description:
Interleukin 10 (IL-10) is an anti-inflammatory cytokine produced by macrophages and type 2 T helper (Th2) cells. IL-10 inhibits the production of pro-inflammatory cytokines such as interferon gamma (IFN-ƴ), tumor necrosis factor alpha (TNF-α), interleukin 2 (IL-2), interleukin 3 (IL-3), interleukin 4 (IL-4), and granulocyte-macrophage colony-stimulating factor (GM-CSF), made by macrophages and regulatory T cells. IL-10 also suppresses antigen presentation on antigen presenting cells, and enhances the survival, proliferation, and antibody production of B cells.
Supplier:
Bel-Art Products
Description:
The Cleanware™ Pipette Rinsing System for pipette cleaning and storage has an effective, reliable design that ensures safe, efficient operation.
Supplier:
GLOBAL COOLING, INC.
Description:
North America 240V Cord- 6 Ft. Long Electrical Cord Standard Nema 6-15R Compatiable With All Products
Catalog Number:
(77440-062)
Supplier:
Bioss
Description:
This gene generates several transcript variants which differ in their first exons. At least three alternatively spliced variants encoding distinct proteins have been reported, two of which encode structurally related isoforms known to function as inhibitors of CDK4 kinase. The remaining transcript includes an alternate first exon located 20 Kb upstream of the remainder of the gene; this transcript contains an alternate open reading frame (ARF) that specifies a protein which is structurally unrelated to the products of the other variants. This ARF product functions as a stabilizer of the tumor suppressor protein p53 as it can interact with, and sequester, the E3 ubiquitin-protein ligase MDM2, a protein responsible for the degradation of p53. In spite of the structural and functional differences, the CDK inhibitor isoforms and the ARF product encoded by this gene, through the regulatory roles of CDK4 and p53 in cell cycle G1 progression, share a common functionality in cell cycle G1 control. This gene is frequently mutated or deleted in a wide variety of tumors, and is known to be an important tumor suppressor gene. [provided by RefSeq, Sep 2012].
Catalog Number:
(77439-190)
Supplier:
Bioss
Description:
This gene generates several transcript variants which differ in their first exons. At least three alternatively spliced variants encoding distinct proteins have been reported, two of which encode structurally related isoforms known to function as inhibitors of CDK4 kinase. The remaining transcript includes an alternate first exon located 20 Kb upstream of the remainder of the gene; this transcript contains an alternate open reading frame (ARF) that specifies a protein which is structurally unrelated to the products of the other variants. This ARF product functions as a stabilizer of the tumor suppressor protein p53 as it can interact with, and sequester, the E3 ubiquitin-protein ligase MDM2, a protein responsible for the degradation of p53. In spite of the structural and functional differences, the CDK inhibitor isoforms and the ARF product encoded by this gene, through the regulatory roles of CDK4 and p53 in cell cycle G1 progression, share a common functionality in cell cycle G1 control. This gene is frequently mutated or deleted in a wide variety of tumors, and is known to be an important tumor suppressor gene. [provided by RefSeq, Sep 2012].
Supplier:
DWK Life Sciences (KIMBLE)
Description:
All sizes have tabs for easy removal. Wheaton Science Products completes your package with the right closure. We provide a wide variety of caps, seals and stoppers to ensure a perfect fit for your container.
Catalog Number:
(100500-238)
Supplier:
Electron Microscopy Sciences
Description:
Pressurized duster removes dust and dirt with pure moisture free blasts. There is more product at less cost per ounce. Extension tube is included with the can. Its new concentrated formula will give you 57% more blasts per ounce, 17% more blasts per can. Safe for the environment. Contains: Formula S (Difluoroethane) - 100% safe for the ozone.
Catalog Number:
(76006-956)
Supplier:
Remco Products
Description:
This extension pole reaches lengths of 6 to 19.75 feet.
Supplier:
PIP
Description:
Electrical Safety Kits allow users to pick the class that an application requires, the color and size rubber gloves required, and Protective Industrial Products does the rest by assembling a kit that works.
Catalog Number:
(CA95021-378)
Supplier:
HiMedia
Description:
For the detection and enumeration of clostridia in meat and meat products.
Catalog Number:
(47750-528)
Supplier:
Bel-Art Products
Description:
Designed to perform tedious tasks with minimum effort, the 96 open-ended pipet tips of this unique product fit all types of 96 well plates from flat, "V", or round bottom plates to 0.2 mL thin walled PCR plates and tubes.
Catalog Number:
(10430-744)
Supplier:
Bioss
Description:
The early region (E1) of the adenovirus genome, responsible for transforming activity, is localized within the left most 11% of the viral genome and consists of two transcriptional units E1A and E1B. E1A is sufficient for partial transformation and immortalization of primary cells. E1A gene products are necessary for normal levels of transcription of the other early regions of the adenovirus genome during productive infection and are able to either activate or repress the transcription of specific cellular genes. E1A forms specific complexes with cellular proteins including p105 causing inhibition of the cell cycle inducing arresting function of p105.
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