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Isolation+and+Cleanup+HyClone+products+(Cytiva)
Catalog Number:
(10371-972)
Supplier:
Bioss
Description:
Stress-activated serine/threonine-protein kinase involved in cytokines production, endocytosis, reorganization of the cytoskeleton, cell migration, cell cycle control, chromatin remodeling, DNA damage response and transcriptional regulation. Following stress, it is phosphorylated and activated by MAP kinase p38-alpha/MAPK14, leading to phosphorylation of substrates. Phosphorylates serine in the peptide sequence, Hyd-X-R-X(2)-S, where Hyd is a large hydrophobic residue. Phosphorylates ALOX5, CDC25B, CDC25C, ELAVL1, HNRNPA0, HSF1, HSP27/HSPB1, KRT18, KRT20, LIMK1, LSP1, PABPC1, PARN, PDE4A, RCSD1, RPS6KA3, TAB3 and TTP/ZFP36. Mediates phosphorylation of HSP27/HSPB1 in response to stress, leading to dissociate HSP27/HSPB1 from large small heat-shock protein (sHsps) oligomers and impair their chaperone activities and ability to protect against oxidative stress effectively. Involved in inflammatory response by regulating tumor necrosis factor (TNF) and IL6 production post-transcriptionally: acts by phosphorylating AU-rich elements (AREs)-binding proteins ELAVL1, HNRNPA0, PABPC1 and TTP/ZFP36, leading to regulate the stability and translation of TNF and IL6 mRNAs. Phosphorylation of TTP/ZFP36, a major post-transcriptional regulator of TNF, promotes its binding to 14-3-3 proteins and reduces its ARE mRNA affinity leading to inhibition of dependent degradation of ARE-containing transcript. Also involved in late G2/M checkpoint following DNA damage through a process of post-transcriptional mRNA stabilization: following DNA damage, relocalizes from nucleus to cytoplasm and phosphorylates HNRNPA0 and PARN, leading to stabilize GADD45A mRNA. Involved in toll-like receptor signaling pathway (TLR) in dendritic cells: required for acute TLR-induced macropinocytosis by phosphorylating and activating RPS6KA3.
Supplier:
Labconco
Description:
Attachment port lid has a 7.62 cm (3") diameter opening to permit the use of heated drying chamber or manifolds 26617-017, -021 or -023 atop the FreeZone® 4.5 L freeze dry systems (26671-511, -513).
Catalog Number:
(CA710-1622)
Supplier:
Rockland Immunochemical
Description:
This product has been assayed against 1.0 µg of Mouse IgG in a standard capture ELISA using Peroxidase Conjugated Streptavidin and ABTS (2,2’-azino-bis-[3-ethylbenthiazoline-6-sulfonic acid])
Supplier:
Biotium
Description:
with CF660C. CF660C can still be sufficiently excited by the 633/635 nm laser with emission at 685 nm. CF660C is several fold brighter and significantly more photostable than Alexa Fluor 660.
Catalog Number:
(76082-612)
Supplier:
Bioss
Description:
Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFA, VEGFC and VEGFD. Plays an essential role in the regulation of angiogenesis, vascular development, vascular permeability, and embryonic hematopoiesis. Promotes proliferation, survival, migration and differentiation of endothelial cells. Promotes reorganization of the actin cytoskeleton. Isoforms lacking a transmembrane domain, such as isoform 2 and isoform 3, may function as decoy receptors for VEGFA, VEGFC and/or VEGFD. Isoform 2 plays an important role as negative regulator of VEGFA- and VEGFC-mediated lymphangiogenesis by limiting the amount of free VEGFA and/or VEGFC and preventing their binding to FLT4. Modulates FLT1 and FLT4 signaling by forming heterodimers. Binding of vascular growth factors to isoform 1 leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate and the activation of protein kinase C. Mediates activation of MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Mediates phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, reorganization of the actin cytoskeleton and activation of PTK2/FAK1. Required for VEGFA-mediated induction of NOS2 and NOS3, leading to the production of the signaling molecule nitric oxide (NO) by endothelial cells. Phosphorylates PLCG1. Promotes phosphorylation of FYN, NCK1, NOS3, PIK3R1, PTK2/FAK1 and SRC.
Catalog Number:
(89493-662)
Supplier:
Genscript
Description:
THE™ Anti-GST Monoclonal antibody (Mouse) recognizes GST localized at the C-terminal, N-terminal and internal region ofGST-tagged fusion proteins.
Catalog Number:
(470122-614)
Supplier:
Bel-Art
Description:
Features a convenient writing platform which allows both left- and right-handed users to write on the tape before applying it. Accepts 3" ID tape reels up to 1" wide. Dispenser only. For use with Autoclavable Tape.
Catalog Number:
(20000-713)
Supplier:
PIP
Description:
Combination of comfortable nylon shell, and a protective PU coating makes this glove ideal for use in electronic and computer assembly, quality control, inspection and general assembly.
Supplier:
Thermo Fisher Scientific
Description:
Our low percentage Coefficient of Variation (%CV) ensures product consistency and performance from every lot.
Catalog Number:
(75848-720)
Supplier:
Elkay Plastics
Description:
These bags are particularly well suited for pre-packaging of sandwich type items because they load very quickly and seal easily and securely.
Catalog Number:
(CA80055-990)
Supplier:
MilliporeSigma
Description:
Inhibitor of calpain I (Ki=120nM), calpain II (Ki=230nM), cathepsin B (Ki=100nM), and cathepsin L (Ki=0.6nM). Inhibits activation-induced programmed cell death and restores defective immune responses in HIV+ donors. Also prevents nitric oxide production by activated macrophages by interfering with transcription of the inducible nitric oxide synthase gene.
Supplier:
Bel-Art Products
Description:
These rings fit neatly around the neck of filtering flasks with side-arm tubing connections without disconnecting the tubing.
Supplier:
New Pig
Description:
Eight layers of 100% polypropylene are thermally bonded to make PIG® Absorbent Mat Pads exceptionally strong; they won't rip, tear or fray even when saturated.
Supplier:
Bel-Art Products
Description:
The Roxy M™ Repeating Pipettor provides precise, accurate, and reliable repetitive pipetting of volumes from 1 μl to 5 ml.
Catalog Number:
(76116-814)
Supplier:
Bioss
Description:
This gene encodes a protein that localizes to the nucleus and expression of this gene is induced in response to elevated levels of axin. The Wnt signalling pathway, which is negatively regulated by axin, is important in axis formation in early development and impaired regulation of this signalling pathway is often involved in tumors. A decreased level of expression of this gene in tumors compared to the level of expression in their corresponding normal tissues suggests that this gene product has a tumor suppressor function.
Supplier:
Spectrum Chemicals
Description:
Sodium Gluconate, FCC is used as surface cleaning agent for metals and glass bottles. The FCC grade meets the requirements of the Food Chemical Codex indicates and is suitable for all food, beverage and nutritional supplement applications. Spectrum Chemical offers over 300 Food grade chemical ingredients packaged in laboratory size bottles to production drum quantities and are manufactured, packaged and stored under current Good Manufacturing Practices (cGMP) per 21CFR part 211 in FDA registered and inspected facilities.
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 is still displayed and you need assistance, please call us at 1-800-932-5000.
Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the
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