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Pure+and+Ultra+Pure+Water+Systems
Supplier:
Corning
Description:
PP, non sterile. Compatible with a full range of PCR, sequencing and Real-Time PCR equipment.
Supplier:
VWR International
Description:
Flexible bellows are constructed of pure, non-contaminating PTFE.
Supplier:
VWR International
Description:
Round-bottom tubes are designed with good temperature and chemical resistance.
Supplier:
VWR International
Description:
Centrifuge tubes are constructed from sturdy PTFE and feature screw caps.
Supplier:
VWR International
Description:
Microscope cover glasses are made of pure white borosilicate glass with excellent chemical resistance and flatness, and are free of bubbles and scratches.
Supplier:
VWR
Description:
Ward’s® PURE Preserved Specimens - the best dissection experience from start to finish.
Supplier:
VWR International
Description:
Molded in pure, FDA-approved PTFE, these samarium-cobalt elliptical magnets feature increased magnetic strength and are almost totally resistant to demagnetization.
Supplier:
VWR
Description:
Ward's® PURE Preserved Specimens - the best dissection experience from start to finish.
Catalog Number:
(470325-042)
Supplier:
VWR
Description:
Ward's® PURE Preserved Specimens - the best dissection experience from start to finish.
Supplier:
VWR
Description:
Ward’s® PURE Preserved Specimens - the best dissection experience from start to finish.
Supplier:
VWR
Description:
Ward’s® PURE Preserved Specimens - the best dissection experience from start to finish.
Supplier:
VWR International
Description:
Excellent choice for high pressure, low spallation peristaltic tubing applications.
Catalog Number:
(470314-638)
Supplier:
VWR
Description:
Ward's® PURE Preserved Specimens - the best dissection experience from start to finish.
Catalog Number:
(470324-266)
Supplier:
VWR
Description:
Ward’s® PURE Preserved Specimens - the best dissection experience from start to finish.
Catalog Number:
(CA87003-236)
Supplier:
BDH
Description:
Ultra high-purity water for quantitative trace metal analysis in the parts-per-trillion (ppt) level.
Supplier:
Enzo Life Sciences
Description:
The proteasome is widely recognised as the central enzyme of non-lysosomal protein degradation. It is responsible for intracellular protein turnover and it is also critically involved in many regulatory processes and, in higher eukaryotes, in antigen processing. An enzymatic cascade is responsible for the attachment of multiple ubiquitin molecules to lysine residues of proteins targeted for degradation. The 26S proteasome is the key enzyme of the ubiquitin/ATP-dependent pathway of protein degradation.
The catalytic core of this unusually large (2000kDa, 450Å in length) complex (31 subunits) is formed by the 20S proteasome, a barrel shaped structure shown by electron microscopy to comprise of four rings each containing seven subunits. 20S Proteasomes degrade only unfolded proteins in an energy-independent manner, whereas 26S proteasomes degrade native and ubiquitinylated proteins in an ATP-dependent manner. The native protein substrates are recognised by subunits, some with ATP binding sites, of the outer 19S caps of the 26S proteasome. The 19S regulatory subunit recognizes ubiquitinated proteins and plays an essential role in unfolding and translocating targets into the lumen of the 20S subunit. A second activator which can associate with the 20S proteasome in the absence of ATP is known as PA28 or the 11S regulator. The pure PA28 activator is a complex of two alternating subunits, PA28α and PA28β, which share approximately 50% homology but also show considerable similarity (30-40%) to a nuclear protein of unknown function, the Ki autoantigen (recently referred to as PA28γ). These subunits, with an apparent relative molecular weight of approximately 29kDa, form ringlike heteromeric complexes of ~200kDa possibly with an α3β3 stoichiometry. Electron microscopic studies have shown PA28 to be a ring shaped particle which, like the 19S, caps the 20S proteasome, by binding to the α-rings, at both or either end. The complex may, however, be readily dissociated. The finding that PA28 modulates the proteasome-catalysed production of antigenic peptides presented to the immune system on MHC class I molecules indicates a cellular function of this activator in antigen processing. Several genetic diseases are associated with defects in the ubiquitin-proteasome pathway. Some examples of affected proteins include those linked to cystic fibrosis, Angelman's syndrome, and Liddle syndrome.
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 is still displayed and you need assistance, please call us at 1-800-932-5000.
Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the
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