chromatography+columns+HyClone+products+(Cytiva)
Catalog Number:
(77439-068)
Supplier:
Bioss
Description:
This gene encodes a nuclear phosphoprotein that plays a role in maintaining genomic stability, and it also acts as a tumor suppressor. The encoded protein combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC). This gene product associates with RNA polymerase II, and through the C-terminal domain, also interacts with histone deacetylase complexes. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in this gene are responsible for approximately 40% of inherited breast cancers and more than 80% of inherited breast and ovarian cancers. Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene. Many alternatively spliced transcript variants, some of which are disease-associated mutations, have been described for this gene, but the full-length natures of only some of these variants has been described. A related pseudogene, which is also located on chromosome 17, has been identified. [provided by RefSeq, May 2009].
Catalog Number:
(10098-132)
Supplier:
Prosci
Description:
IL4 is a pleiotropic cytokine produced by activated T cells, mast cells and basophils. It is a ligand for Interleukin 4 receptor. The Interleukin 4 receptor also binds to IL13, which may contribute to many overlapping functions of this cytokine and IL13. IL4 elicits many different biological responses, but has two dominant functions. The first is regulating differentiation of naïve CD4+ T cell to the Th2 type. Th2 cells produce IL4, IL5, IL10 and IL13, which tend to favor a humoral immune response while suppressing a cell mediated immune response controlled by Th1 cells. STAT6, a signal transducer and activator of transcription, has been shown to play a central role in mediating the immune regulatory signal of this cytokine. The second is regulating IgE and IgG1 production by B cells. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.
Supplier:
Zymo Research
Description:
Clean and concentrate up to 5 μg DNA with ≥6 μL elution in as little as 2 minutes with 0 μL wash residue carryover.
Catalog Number:
(75843-574)
Supplier:
BIOGEMS INTERNATIONAL INC.
Description:
The 2F1 monoclonal antibody is specific for the mouse Killer cell Lectin-like Receptor G1 (KLRG1), a homodimer consisting of two N-glycosylated subunits of 30-38 kDa, also known as MAFA (Mast cell Function-associated Antigen). The antigen contains a cytoplasmic motif similar to ITIM (the immunoreceptor tyrosine-based inhibitory motif). KLRG1 is a receptor for cadherin, a family of transmembrane glycoproteins that mediate cell adhesion, and a common marker of T cell senescence. The receptor is believed to play an important role in the innate and adaptive immune system through the regulation of leukocytes. It is expressed on lymphokine-activated killer (LAK) cells, adherent LAK (A-LAK) cells, a sub-set of natural killer (NK) cells, T cells. In NK cells, it inhibits cytokine production and cytotoxicity activity.The receptor expression was not detected on the mouse peritoneal mast cells, or bone marrow mast cells.
Catalog Number:
(89289-596)
Supplier:
Genetex
Description:
Rabbit polyclonal antibody to LATS1/2
Catalog Number:
(89282-106)
Supplier:
Genetex
Description:
Rabbit polyclonal antibody to CREB (phospho Ser129)
Catalog Number:
(89280-008)
Supplier:
Genetex
Description:
Rabbit Polyclonal Antibody to MMP19
Catalog Number:
(89290-650)
Supplier:
Genetex
Description:
Rabbit polyclonal antibody to PPP1R16B
Catalog Number:
(89290-622)
Supplier:
Genetex
Description:
Rabbit polyclonal antibody to BORG3
Catalog Number:
(89289-600)
Supplier:
Genetex
Description:
Rabbit polyclonal antibody to ZDHHC7
Catalog Number:
(89290-992)
Supplier:
Genetex
Description:
Rabbit polyclonal antibody to OR13C3
Catalog Number:
(89332-130)
Supplier:
Genetex
Description:
Clone: 1061 Conjugation: FITC Purity: Purified by protein A chromatography or sequential differential precipitations Species Reactivity: Bacteria Tested Applications: ELISA, ICC/IF Pkg Size: 500 ul
Supplier:
Optimize
Description:
The OPTI-TRAP™ is a bi-directional trap cartridge system which is used individually or in a series for sample concentration and purification.
Catalog Number:
(10085-966)
Supplier:
Proteintech
Description:
Tumour necrosis factor-alpha (TNF-alpha) is a key mediator of inflammation in host defence against infection and in autoimmune disease. Its production is controlled post-transcriptionally by multiple RNA-binding proteins that interact with the TNF-alpha AU-rich element and regulate its expression; Fragile X mental retardation-related protein 1 (FXR1) is one of these. FXR1 (fragile-X-mental retardation-related protein 1) are RNA-binding proteins that have been demonstrated to impact miRNA-mediated, post-transcriptional gene regulation, and required for embryonic and postnatal development of muscle tissue. It can regulate intracellular transport and local translation of certain mRNAs
Catalog Number:
(89416-588)
Supplier:
Prosci
Description:
VGF Antibody: VGF was initially identified as a rapidly regulated gene product in nerve growth factor-treated PC12 cells. This protein is synthesized in neurons in the central and peripheral nervous system as well as in the pituitary, adrenal medulla, endocrine cells of the stomach, and pancreatic beta cells. VGF is thought to be involved in organism energy balance and regulation of homeostasis as mice lacking this gene show deficits in these areas. More recent results suggest that VGF is upregulated by brain-derived neurotrophic factor (BDNF) and can stimulate the proliferation of hippocampal progenitor cells and produce antidepressant-like behavioral effects, suggesting that this pathway may be a suitable target for therapeutic treatments.
Catalog Number:
(89331-274)
Supplier:
Genetex
Description:
Purity: Purified by protein A chromatography or sequential differential precipitations Species Reactivity: Bacteria Tested Applications: ELISA, ICC/IF, IHC, WB Pkg Size: 500 ul
Inquire for Price
Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the
![]()
Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the
![]()
You must log in to order restricted items. We request that you provide the required business documentation to purchase this product for the first time.
To order chemicals, medical devices, or other restricted products please provide identification that includes your business name and shipping address via email CMD_NA@vwr.com or fax 484.881.5997 referencing your VWR account number . Acceptable forms of identification are:
-Additional Documentation May be needed to purchase this item. A VWR representative will contact you if needed.
This product has been blocked by your organization. Please contact your purchasing department for more information.
The original product is no longer available. The replacement shown is available.
This product is currently unavailable but limited stock may be available in our extended warehouse network. Please call 1-800-932-5000 and a VWR Customer Service Representative will help you.
|
|||||||||