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chromatography+columns+HyClone+products+(Cytiva)
Catalog Number:
(10491-048)
Supplier:
Bioss
Description:
Making up nearly 6% of the human genome, chromosome 6 contains around 1,200 genes within 170 million base pairs of sequence. Deletion of a portion of the q arm of chromosome 6 is associated with early onset intestinal cancer suggesting the presence of a cancer susceptibility locus. Porphyria cutanea tarda is associated with chromosome 6 through the HFE gene which, when mutated, predisposes an individual to developing this porphyria. Notably, the PARK2 gene, which is associated with Parkinson's disease, and the genes encoding the major histocompatiblity complex proteins, which are key molecular components of the immune system and determine predisposition to rheumatic diseases, are also located on chromosome 6. Stickler syndrome, 21-hydroxylase deficiency and maple syrup urine disease are also associated with genes on chromosome 6. A bipolar disorder susceptibility locus has been identified on the q arm of chromosome 6. The C6orf58 gene product has been provisionally designated C6orf58 pending further characterization.
Catalog Number:
(10490-950)
Supplier:
Bioss
Description:
Making up nearly 6% of the human genome, chromosome 6 contains around 1,200 genes within 170 million base pairs of sequence. Deletion of a portion of the q arm of chromosome 6 is associated with early onset intestinal cancer, suggesting the presence of a cancer susceptibility locus. Porphyria cutanea tarda is associated with chromosome 6 through the HFE gene which, when mutated, predisposes an individual to developing this porphyria. Notably, the PARK2 gene, which is associated with Parkinson's disease, and the genes encoding the major histocompatiblity complex proteins, which are key molecular components of the immune system and determine predisposition to rheumatic diseases, are also located on chromosome 6. Stickler syndrome, 21-hydroxylase deficiency and maple syrup urine disease are also associated with genes on chromosome 6. A bipolar disorder susceptibility locus has been identified on the q arm of chromosome 6. The C6orf120 gene product has been provisionally designated C6orf120 pending further characterization.
Catalog Number:
(10749-672)
Supplier:
Prosci
Description:
TSC2 Antibody: Tuberous sclerosis complex (TSC) is an autosomal dominant tumor syndrome caused by mutations in either of the TSC1 or TSC2 tumor suppressor genes. The products of these genes form a protein complex that indirectly decreases the signaling of the mammalian Target of Rapamycin (TOR), an evolutionarily conserved serine/threonine kinase that regulates cell growth and cell cycle through its ability to integrate signals from nutrient levels and growth factors. TOR activity is stimulated by Rheb, a member of the Ras superfamily of G-proteins, when the GTP/GDP ratio bound to Rheb is high. Immunoprecipitated TSC1/TSC2 has been shown to stimulate Rheb GTPase activity in vitro, suggesting that the TSC1/TSC2 complex decreases the ability of Rheb to stimulate TOR activity. This is supported by experiments showing that overexpression of TSC1 and TSC2 results in a significant decrease in the GTP/GDP ratio bound to Rheb and the inhibition of cell growth. At least three isoforms of TSC2 exist.
Catalog Number:
(10482-800)
Supplier:
Bioss
Description:
Chromosome 1 is the largest human chromosome spanning about 260 million base pairs and making up 8% of the human genome. There are about 3,000 genes on chromosome 1, and considering the great number of genes there are also a large number of diseases associated with chromosome 1. Notably, the rare aging disease Hutchinson-Gilford progeria is associated with the LMNA gene which encodes lamin A. When defective, the LMNA gene product can build up in the nucleus and cause characteristic nuclear blebs. The mechanism of rapidly enhanced aging is unclear and is a topic of continuing exploration. The MUTYH gene is located on chromosome 1 and is partially responsible for familial adenomatous polyposis. Stickler syndrome, Parkinsons, Gaucher disease and Usher syndrome are also associated with chromosome 1. A breakpoint has been identified in 1q which disrupts the DISC1 gene and is linked to schizophrenia. Aberrations in chromosome 1 are found in a variety of cancers including head and neck cancer, malignant melanoma and multiple myeloma.
Supplier:
HARDY DIAGNOSTICS CA
Description:
CRITERION™ Agar, Plant Tissue Culture, Grade Purified, used for culturing plant tissues.
Supplier:
AGILENT TECHNOLOGIES, INC (CSD) CA
Description:
PFA sample uptake tubing with different Int.Ø available to suit your ICP-MS application.
Catalog Number:
(89416-134)
Supplier:
Prosci
Description:
RIG-1 Antibody: The innate immune system detects viral infection by recognizing various viral components and triggers antiviral responses. Like the toll-like receptor 3 (TLR3), the cytoplasmic helicase retinoic acid inducible gene protein 1 (RIG-1) recognizes double-stranded (ds) RNA, a molecular pattern associated with viral infection. Unlike TLR3 however, RIG-1 activates the kinases TBK1 and IKK epsilon through the adaptor protein IPS-1. These kinases then phosphorylate the transcription factors IRF-3 and IRF-7 which are essential for the expression of type-I interferons. RIG-1 is required for the production of interferons in response to RNA viruses including paramyxoviruses, influenza virus, and Japanese encephalitis virus.
Catalog Number:
(89348-858)
Supplier:
Genetex
Description:
Rabbit Polyclonal antibody to MIF (macrophage migration inhibitory factor (glycosylation-inhibiting factor))
Catalog Number:
(89291-428)
Supplier:
Genetex
Description:
Rabbit polyclonal antibody to TENS3
Supplier:
Thermo Scientific
Description:
Barnstead Mega-Pure Glass Stills effectively remove inorganic solids, organics, with boiling points higher than water, bacteria, and pyrogens
Supplier:
Scientific Industries
Description:
Vortex Genie® Mixers are available in multiple models and with a vast array of available platforms and accessories.
Catalog Number:
(89301-882)
Supplier:
Genetex
Description:
Rabbit polyclonal to DYRK1A (N-term)
Catalog Number:
(89291-240)
Supplier:
Genetex
Description:
Rabbit polyclonal antibody to HOXD10
Catalog Number:
(89290-728)
Supplier:
Genetex
Description:
Rabbit polyclonal antibody to HOXB9
Catalog Number:
(89290-508)
Supplier:
Genetex
Description:
Rabbit polyclonal antibody to CDYL2
Catalog Number:
(89290-732)
Supplier:
Genetex
Description:
Rabbit polyclonal antibody to HLX1
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