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chromatography+columns+HyClone+products+(Cytiva)
Catalog Number:
(10231-728)
Supplier:
Bioss
Description:
Transmembrane serine/threonine kinase forming with the TGF-beta type I serine/threonine kinase receptor, TGFBR1, the non-promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. The formation of the receptor complex composed of 2 TGFBR1 and 2 TGFBR2 molecules symmetrically bound to the cytokine dimer results in the phosphorylation and the activation of TGFRB1 by the constitutively active TGFBR2. Activated TGFBR1 phosphorylates SMAD2 which dissociates from the receptor and interacts with SMAD4. The SMAD2-SMAD4 complex is subsequently translocated to the nucleus where it modulates the transcription of the TGF-beta-regulated genes. This constitutes the canonical SMAD-dependent TGF-beta signaling cascade. Also involved in non-canonical, SMAD-independent TGF-beta signaling pathways.
Catalog Number:
(76226-076)
Supplier:
Rockland Immunochemical
Description:
Conjugated Anti-Monkey IgG (H&L) Biotin antibody generated in rabbit detects specifically monkey IgG heavy and light chains. Secreted as part of the adaptive immune response by plasma B cells, immunoglobulin G constitutes 75% of serum immunoglobulins. IgG binds to viruses, bacteria, as well as fungi and facilitates their destruction or neutralization via agglutination (and thereby immobilizing them), activation of the compliment cascade, and opsinization for phagocytosis. The whole IgG molecule possesses both the F(c) region, recognized by high-affinity Fc receptor proteins, as well as the F(ab) region possessing the epitope-recognition site. Both heavy and light chains of the antibody molecule are present. This biotin conjugated anti-Monkey IgG (H&L) secondary antibody is ideal for investigators who routinely perform western blot, ELISA, Immunohistochemistry, and more general immunoassays. When choosing a secondary antibody product, consideration must be given to species and immunoglobulin specificity, conjugate type, fragment and chain specificity, level of cross-reactivity, and host-species source and fragment.
Catalog Number:
(CA97012-918)
Supplier:
PERKINELMER SCIENTIFIC CANADA ULC
Description:
This 1-slot quartz torch is designed for use with Optima™ 3x00 DV ICP-OES series instruments.
Catalog Number:
(10104-032)
Supplier:
Prosci
Description:
The exact function of ANKRD13B remains unknown.
Catalog Number:
(10108-284)
Supplier:
Prosci
Description:
The function remains unknown.
Catalog Number:
(10101-690)
Supplier:
Prosci
Description:
ZBTB40 may be involved in transcriptional regulation.
Catalog Number:
(89417-466)
Supplier:
Prosci
Description:
RNF8 Antibody: RNF8 was identified as a ubiquitin ligase (E3) containing a RING finger motif and a FHA domain. This protein has been shown to interact with several class II ubiquitin-conjugating enzymes including UBE2E1/UBCH6, UBE2E2, and UBE2E3. RNF8 assembles at DNA double-strand breaks (DSBs) via interactions though the FHA domain with the adaptor protein MDC1, resulting in an increase in DSB-associated H2A histone ubiquitinations mediated by the associated ubiquitin ligase RNF168 followed by the accumulation of 53BP1 and BRCA1 repair proteins. Together with RNF168, RNF8 plays an integral part of class switch recombination in B cells, allowing the production of several classes of antibodies, through the recruitment of 53BP1 and BRCA1 to the DSB sites.
Catalog Number:
(10495-470)
Supplier:
Bioss
Description:
The ENTHD1 gene is conserved in chimpanzee, dog, cow, mouse and rat, and maps to human chromosome 22q13.1. Chromosome 22 contains over 500 genes and about 49 million bases. Being the second smallest human chromosome, 22 contains a surprising variety of interesting genes. Phelan-McDermid syndrome, Neurofibromatosis type 2 and autism are associated with chromosome 22. A schizophrenia susceptibility locus has been identified on chromosome 22 and studies show that 22q11 deletion symptoms include a high incidence of schizophrenia. Translocations between chromosomes 9 and 22 may lead to the formation of the Philadelphia Chromosome and the subsequent production of the novel fusion protein, BCR-Abl, a potent cell proliferation activator found in several types of leukemia.
Catalog Number:
(10492-810)
Supplier:
Bioss
Description:
JWA is a four-transmembrane environmental responsive protein which binds to the CC chemokine recepor 5 (CCR5), a major co-receptor for human immunodeficiency virus (HIV). JWA is involved in environmental stress-responsive pathways in K562 cells, an erythroleukemia cell line derived from patients with chronic myeloid leukemia. Environmental stressors to K562 cells such as heat shock, a higher temperature than the ideal body temperature of the organism from which the cell line was derived, and oxidative stress, the production of oxygen-centered free radicals, regulate and increase the expres-sion of JWA. This response to environmental stressors suggests similiarity of JWA to heat shock protein 70 (HSP70), which is upregulated by heat stress and toxic chemicals.
Catalog Number:
(10101-036)
Supplier:
Prosci
Description:
PSIP1 is a transcriptional coactivator. It also acts as an adaptor to coordinate pre-mRNA splicing and transcriptional activation of class II genes.
Catalog Number:
(10099-996)
Supplier:
Prosci
Description:
NUDT18 belongs to the Nudix hydrolase family. It contains 1 nudix hydrolase domain. NUDT18 probably mediates the hydrolysis of some nucleoside diphosphate derivatives.
Catalog Number:
(10354-650)
Supplier:
Bioss
Description:
Serine kinase that plays an essential role in the NF-kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses. Acts as part of the canonical IKK complex in the conventional pathway of NF-kappa-B activation and phosphorylates inhibitors of NF-kappa-B on 2 critical serine residues. These modifications allow polyubiquitination of the inhibitors and subsequent degradation by the proteasome. In turn, free NF-kappa-B is translocated into the nucleus and activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis. In addition to the NF-kappa-B inhibitors, phosphorylates several other components of the signaling pathway including NEMO/IKBKG, NF-kappa-B subunits RELA and NFKB1, as well as IKK-related kinases TBK1 and IKBKE. IKK-related kinase phosphorylations may prevent the overproduction of inflammatory mediators since they exert a negative regulation on canonical IKKs. Also phosphorylates other substrates including NCOA3, BCL10 and IRS1. Within the nucleus, acts as an adapter protein for NFKBIA degradation in UV-induced NF-kappa-B activation.
Catalog Number:
(10106-798)
Supplier:
Prosci
Description:
DNAJC17's function is not determined.
Catalog Number:
(10104-090)
Supplier:
Prosci
Description:
The exact function of OLFML2A is not known.
Catalog Number:
(10099-598)
Supplier:
Prosci
Description:
ZNF207 is a new candidate transcription factor.
Catalog Number:
(89349-962)
Supplier:
Genetex
Description:
Rabbit Polyclonal antibody to T-Plastin (plastin-3)
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