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chromatography+columns+HyClone+products+(Cytiva)
Catalog Number:
(102981-418)
Supplier:
Adipogen
Description:
Unmethylated CG dinucleotides within particular sequence contexts are responsible for the immunostimulatory activity of bacterial DNA. Synthetic oligonucleotides (ODN) that contain such CpG motifs (CpG ODNs) mimic microbial DNA. The innate immune system of vertebrates has the ability to recognize CpG motifs in microbial DNA via the Toll-like receptor (TLR) 9 if the CpG ODN were free of additional immune stimulatory contaminants often present in synthetic commercial CpG ODN preparations designed for molecular biology applications (i.e. PCR). Given that high quality CpG ODNs were used, a close link has been established between the expression of TLR9 on certain immune cell subsets and the modulation of the immune system by CpG DNA. Different types of CpG ODNs were identified based on their differing biological effects on different cell types: ODN Type A is a potent inducer of IFN-alpha in human PDC, (i.e. ODN 1585 or 2216) leading to antigen presenting cell (APC) maturation, whereas ODN Type B (i.e. ODN 2006 or ODN 1668 / ODN 1826) is a weak inducer of IFN-alpha but rather stimulates IL-8 production and increasing costimulatory and Ag-presenting molecules and triggers proliferation of B-cells and IgM and IL-6 production. A third type of CpG ODN has been identified, termed ODN Type C, with both high induction of INF-alpha in PDC and activation of B-cells. The sequence of CpG Type C (also called K) (i.e. ODN 2395 or M362) combines elements of both Type A and Type B and contains a central palindromic sequence with CG dinucleotides, a characteristic feature of Type A, and a TCGTCG motif at the 5' end, present in Type B CpG ODNs. Although the CpG motifs are thought to differ between mice and humans, in both species the recognition of CpG ODNs is mediated by TLR9. The optimal CpG motif in humans is GTCGTT and GACGTT for the murine sequence. However, recent evidence suggests that this sequence specificity is restricted to phosphorothioate (PS)-modified ODN and is not observed when a natural phosphodiester backbone is used. In recent years sequence requirements, specificity, signalling pathways and kinetics of the TLR9 suppression by inhibitory ODNs (iODNs) have been investigated.
Catalog Number:
(89349-808)
Supplier:
Genetex
Description:
Rabbit Polyclonal antibody to ATP synthase B1 (ATP synthase, H+ transporting, mitochondrial Fo complex, subunit B1)
Catalog Number:
(CA102500-166)
Supplier:
New England Biolabs (NEB)
Description:
An <i>E. coli</i> strain that carries the cloned and modified SpeI gene from Sphaerotilus species (ATCC 13923). High Fidelity (HF®) Restriction Enzymes have 100% activity in CutSmart® Buffer; single-buffer simplicity means more straightforward and streamlined sample processing. HF enzymes also exhibit dramatically reduced star activity. HF enzymes are all Time-Saver™ qualified and can therefore cut substrate DNA in 5-15 with the flexibility to digest overnight without degradation to DNA. Engineered with performance in mind, HF restriction enzymes are fully active under a broader range of conditions, minimizing off-target products, while offering flexibility in experimental design.
Catalog Number:
(76509-962)
Supplier:
Genscript
Description:
The antibody is recommended as a detection antibody in a pharmacokinetic (PK) bridging assay with capture antibody GenScript, A01966-40, MonoRab Anti-Obinutuzumab Antibody (8G12), mAb, Rabbit.
Catalog Number:
(CAPIPA5-17982)
Supplier:
Thermo Scientific
Description:
This antibody is predicted to react with bovine, canine, mouse, porcine and rat based on sequence homology. The product of this gene belongs to the phosphatase 2A regulatory subunit B family. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes a delta isoform of the regulatory subunit B56 subfamily. Alternatively spliced transcript variants encoding different isoforms have been identified.
Catalog Number:
(CAPIPA5-14795)
Supplier:
Thermo Scientific
Description:
This antibody is predicted to react with mouse based on sequence homology. Protein kinases are enzymes that transfer a phosphate group from a phosphate donor, generally the g phosphate of ATP, onto an acceptor amino acid in a substrate protein. By this basic mechanism, protein kinases mediate most of the signal transduction in eukaryotic cells, regulating cellular metabolism, transcription, cell cycle progression, cytoskeletal rearrangement and cell movement, apoptosis, and differentiation. With more than 500 gene products, the protein kinase family is one of the largest families of proteins in eukaryotes. The family has been classified in 8 major groups based on sequence comparison of their tyrosine (PTK) or serine/threonine (STK) kinase catalytic domains.
Catalog Number:
(CAPIPA5-14215)
Supplier:
Thermo Scientific
Description:
CD163 is an acute phase-regulated receptor involved in clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages and may thereby protect tissues from free hemoglobin-mediated oxidative damage. The protein may play a role in the uptake and recycling of iron, via endocytosis of hemoglobin/haptoglobin and subsequent breakdown of heme. It binds hemoglobin/haptoglobin complexes in a calcium-dependent and pH-dependent manner. And it exhibits a higher affinity for complexes of hemoglobin and multimeric haptoglobin of HP*1F phenotype than for complexes of hemoglobin and dimeric haptoglobin of HP*1S phenotype. It also induces a cascade of intracellular signals that involves tyrosine kinase-dependent calcium mobilization, inositol triphosphate production and secretion of IL6 and CSF1.
Catalog Number:
(10111-624)
Supplier:
Prosci
Description:
The function remains unknown.
Catalog Number:
(89297-966)
Supplier:
Genetex
Description:
Goat polyclonal antibody to STAP2 / BKS
Catalog Number:
(89298-014)
Supplier:
Genetex
Description:
Goat polyclonal antibody to CYP7B1
Catalog Number:
(89296-704)
Supplier:
Genetex
Description:
Goat polyclonal antibody to GCH1
Catalog Number:
(89297-830)
Supplier:
Genetex
Description:
Goat polyclonal antibody to FGFR1
Catalog Number:
(89319-072)
Supplier:
Genetex
Description:
Rabbit Polyclonal antibody to GNAL (guanine nucleotide binding protein (G protein), alpha activating activity polypeptide, olfactory type)
Catalog Number:
(89357-734)
Supplier:
Genetex
Description:
Rabbit Polyclonal antibody to NDUFS1 (NADH dehydrogenase (ubiquinone) Fe-S protein 1, 75kDa (NADH-coenzyme Q reductase))
Catalog Number:
(89349-220)
Supplier:
Genetex
Description:
Rabbit Polyclonal antibody to Contactin 1 (contactin 1)
Catalog Number:
(89349-572)
Supplier:
Genetex
Description:
Rabbit polyclonal antibody to NRP2 (neuropilin 2)
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