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chromatography+columns+HyClone+products+(Cytiva)
Supplier:
Tonbo Biosciences
Description:
The 145-2C11 antibody is specific for mouse CD3e, also known as CD3 epsilon, a 20 kDa subunit of the T cell receptor complex, along with CD3 gamma and CD3 delta. These integral membrane protein chains assemble with additional chains of the T cell receptor (TCR), as well as CD3 zeta chain, to form the T cell receptor – CD3 complex. Together with co-receptors CD4 or CD8, the complex serves to recognize antigens bound to MHC molecules on antigen-presenting cells. Such interactions promote T cell receptor signaling (T cell activation) and can result in a number of cellular responses including proliferation, differentiation, production of cytokines or activation-induced cell death. CD3 is differentially expressed during thymocyte-to-T cell development and on all mature T cells.
Catalog Number:
(102979-194)
Supplier:
Adipogen
Description:
Unmethylated CG dinucleotides within particular sequence contexts are responsible for the immunostimulatory activity of bacterial DNA. Synthetic oligonucleotides (ODN) that contain such CpG motifs (CpG ODNs) mimic microbial DNA. The innate immune system of vertebrates has the ability to recognize CpG motifs in microbial DNA via the Toll-like receptor (TLR) 9 if the CpG ODN were free of additional immune stimulatory contaminants often present in synthetic commercial CpG ODN preparations designed for molecular biology applications (i.e. PCR). Given that high quality CpG ODNs were used, a close link has been established between the expression of TLR9 on certain immune cell subsets and the modulation of the immune system by CpG DNA. Different types of CpG ODNs were identified based on their differing biological effects on different cell types: ODN Type A is a potent inducer of IFN-alpha in human PDC, (i.e. ODN 1585 or 2216) leading to antigen presenting cell (APC) maturation, whereas ODN Type B (i.e. ODN 2006 or ODN 1668 / ODN 1826) is a weak inducer of IFN-alpha but rather stimulates IL-8 production and increasing costimulatory and Ag-presenting molecules and triggers proliferation of B-cells and IgM and IL-6 production. A third type of CpG ODN has been identified, termed ODN Type C, with both high induction of INF-alpha in PDC and activation of B-cells. The sequence of CpG Type C (also called K) (i.e. ODN 2395 or M362) combines elements of both Type A and Type B and contains a central palindromic sequence with CG dinucleotides, a characteristic feature of Type A, and a TCGTCG motif at the 5' end, present in Type B CpG ODNs. Although the CpG motifs are thought to differ between mice and humans, in both species the recognition of CpG ODNs is mediated by TLR9. The optimal CpG motif in humans is GTCGTT and GACGTT for the murine sequence. However, recent evidence suggests that this sequence specificity is restricted to phosphorothioate (PS)-modified ODN and is not observed when a natural phosphodiester backbone is used. In recent years sequence requirements, specificity, signalling pathways and kinetics of the TLR9 suppression by inhibitory ODNs (iODNs) have been investigated.
Supplier:
Spectrum Chemicals
Description:
Potassium Sorbate, Powder, FCC is used as an antimicrobial preservative. The FCC grade meets the requirements of the Food Chemical Codex indicates and is suitable for all food, beverage, nutritional supplement and personal care applications. Spectrum Chemical offers over 300 Food grade chemical ingredients packaged in laboratory size bottles to production drum quantities and are manufactured, packaged and stored under current Good Manufacturing Practices (cGMP) per 21CFR part 211 in FDA registered and inspected facilities
Supplier:
New England Biolabs (NEB)
Description:
T4 Gene 32 Protein is a single-stranded DNA (ssDNA) binding protein required for bacteriophage T4 replication and repair. It cooperatively binds to and stablizes transiently formed regions of ssDNA and plays an important structural role during T4 phage replication. It also has been used extensively to stabilize and mark regions of ssDNA for electron microscopic examination of intracellular DNA structures. Recently, it has been shown to improve restriction enzyme digestion, improve the yield and efficiency of reverse transcription (RT) reactions during RT-PCR, enhance T4 DNA polymerase activity, as well as increase the yield of PCR products.
Catalog Number:
(89320-520)
Supplier:
Genetex
Description:
Rabbit polyclonal antibody to APBB3 (amyloid beta (A4) precursor protein-binding, family B, member 3)
Supplier:
MilliporeSigma
Description:
Designed for convenience and reliability for high efficiency plasmid transformation
Supplier:
AGILENT TECHNOLOGIES, INC (CSD) CA
Description:
Quartz spray chamber and supplies for Agilent ICP-MS, including for use with HMI or UHMI.
Catalog Number:
(CAAG8003-0620)
Supplier:
AGILENT TECHNOLOGIES, INC (CSD) CA
Description:
Capillary tubing and Other Supplies for PerkinElmer AS-90/90A/90plus/91/93plus/S10 autosamplers.
Catalog Number:
(CAAG8003-0560)
Supplier:
AGILENT TECHNOLOGIES, INC (CSD) CA
Description:
RF load coils and power tubes for PerkinElmer NexION 300/350 and ELAN 9000/6x00/DRCs ICP-MS systems.
Catalog Number:
(89318-760)
Supplier:
Genetex
Description:
Rabbit polyclonal antibody to NME5 (non-metastatic cells 5, protein expressed in (nucleoside-diphosphate kinase))
Catalog Number:
(89320-864)
Supplier:
Genetex
Description:
Rabbit Polyclonal antibody to FLJ32786 (leucine-rich repeats and guanylate kinase domain containing)
Supplier:
IBI Scientific
Description:
IBI gPURE DNA Isolation Kit offers a simple and gentle reagent DNA precipitation method for isolating high molecular weight genomic, mitochondrial, or viral DNA
Supplier:
Zymo Research
Description:
Inhibitor-free microbial DNA from any sample validated for microbiome and metagenomic analyses.
Supplier:
New England Biolabs (NEB)
Description:
The Monarch Mag Viral DNA/RNA Extraction Kit provides a rapid and reliable magnetic bead-based process for extracting viral nucleic acids from saliva and respiratory swab samples. The kit combines the efficiency of silica-based nucleic acid purification with the ease of use of magnetic beads.
Supplier:
Restek
Description:
Sample inlets with fittings on each end.
Catalog Number:
(CA97013-462)
Supplier:
PERKINELMER SCIENTIFIC CANADA ULC
Description:
This quartz radial window for the purge extension is used with Optima™ 3000, 3000 SCR, 3x00 RL, 4300 V, 5300 V, and 7300 V ICP-OES series instruments.
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