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chromatography+columns+HyClone+products+(Cytiva)
Supplier:
Biotium
Description:
This antibody recognizes a 53 kDa protein, which is identified as p53 suppressor gene product. It reacts with the mutant as well as the wild form of p53 under denaturing and non-denaturing conditions. Its epitope maps within the N-terminus (aa 20-25) of p53 oncoprotein. p53 is a tumor suppressor gene expressed in a wide variety of tissue types and is involved in regulating cell growth, replication, and apoptosis. It binds to MDM2, SV40 T antigen and human papilloma virus E6 protein. Positive nuclear staining with p53 antibody has been reported to be a negative prognostic factor in breast carcinoma, lung carcinoma, colorectal, and urothelial carcinoma. Anti-p53 positivity has also been used to differentiate uterine serous carcinoma from endometrioid carcinoma as well as to detect intratubular germ cell neoplasia. Mutations involving p53 are found in a wide variety of malignant tumors, including breast, ovarian, bladder, colon, lung, and melanoma.
Catalog Number:
(89296-210)
Supplier:
Genetex
Description:
Goat polyclonal antibody to IKAROS / IKZF1
Catalog Number:
(89274-306)
Supplier:
Genetex
Description:
Mouse monoclonal antibody [1G4] to C10orf82
Catalog Number:
(89271-958)
Supplier:
Genetex
Description:
Mouse monoclonal antibody [2G8] to Sox17
Catalog Number:
(89289-940)
Supplier:
Genetex
Description:
Rabbit polyclonal antibody to TACC1
Catalog Number:
(89273-728)
Supplier:
Genetex
Description:
Mouse Monoclonal antibody [3G9] to GAD67
Catalog Number:
(89298-054)
Supplier:
Genetex
Description:
Goat polyclonal antibody to CYB561D2
Catalog Number:
(89271-668)
Supplier:
Genetex
Description:
Mouse monoclonal antibody [2H5] to USP5
Catalog Number:
(89297-036)
Supplier:
Genetex
Description:
Goat polyclonal antibody to Acylglycerol kinase
Catalog Number:
(89297-698)
Supplier:
Genetex
Description:
Goat polyclonal antibody to Clusterin
Catalog Number:
(89271-462)
Supplier:
Genetex
Description:
Mouse monoclonal antibody [3D9] to IRF7
Catalog Number:
(89303-620)
Supplier:
Genetex
Description:
Goat polyclonal antibody to FSD1
Catalog Number:
(10478-024)
Supplier:
Bioss
Description:
Chromosome 17 makes up over 2.5% of the human genome with about 81 million bases encoding over 1,200 genes. Two key tumor suppressor genes are associated with chromosome 17, namely, p53 and BRCA1. Tumor suppressor p53 is necessary for maintenance of cellular genetic integrity by moderating cell fate through DNA repair versus cell death. Malfunction or loss of p53 expression is associated with malignant cell growth and Li-Fraumeni syndrome. Like p53, BRCA1 is directly involved in DNA repair, though specifically it is recognized as a genetic determinant of early onset breast cancer and predisposition to cancers of the ovary, colon, prostate gland and fallopian tubes. Chromosome 17 is also linked to neurofibromatosis, a condition characterized by neural and epidermal lesions, and dysregulated Schwann cell growth. Alexander disease, Birt-Hogg-Dube syndrome and Canavan disease are also associated with chromosome 17. The FAM134C gene product has been provisionally designated FAM134C pending further characterization.
Catalog Number:
(10459-150)
Supplier:
Bioss
Description:
C12orf23 (chromosome 12 open reading frame 23), also known as FLJ11721, FLJ13959 or MGC17943, is a 116 amino acid multi-pass membrane protein belonging to the UPF0444 family. C12orf23 is encoded by a gene located on human chromosome 12, which encodes over 1,100 genes and comprises approximately 4.5% of the human genome. Chromosome 12 is associated with a number of skeletal deformities, including hypochondrogenesis, achondrogenesis and Kniest dysplasia. Noonan syndrome, which includes heart and facial developmental defects among the primary symptoms, is caused by a mutant form of PTPN11 gene product, SH-PTP2. Chromosome 12 is also home to a homeobox gene cluster which encodes crucial transcription factors for morphogenesis, and the natural killer complex gene cluster encoding C-type lectin proteins which mediate the NK cell response to MHC I interaction. Trisomy 12p leads to facial development defects, seizure disorders and a host of other symptoms varying in severity depending on the extent of mosaicism and is most severe in cases of complete trisomy.
Catalog Number:
(89304-214)
Supplier:
Genetex
Description:
Rabbit polyclonal antibody to FOXO1 (phospho Ser256)
Catalog Number:
(89304-448)
Supplier:
Genetex
Description:
Rabbit Polyclonal antibody to CREB (Phospho Ser129)
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