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chromatography+columns+HyClone+products+(Cytiva)
Catalog Number:
(10666-470)
Supplier:
Bioss
Description:
Huntington disease is associated with the expansion of a polyglutamine tract, greater than 35 repeats, in the HD gene product, huntingtin. HIP1, a membrane-associated protein, binds specifically to the N-terminus of human huntingtin. HIP1 is ubiquitously expressed in different brain regions at low levels and exhibits nearly identical subcellular fractionation as huntingtin. The HIP1 gene locates to the human chromosome 7q11.23. The huntingtin-HIP1 interaction is restricted to the brain and is inversely correlated to the polyglutamine length in the huntingtin, suggesting that loss of normal huntingtin-HIP1 interaction may compromise the membrane-cytoskeletal integrity in the brain. HIP1 contains an endocytic multidomain protein with a C-terminal Actin-binding domain, a central coiled-coil forming region and an N-terminal ENTH domain. HIP1 may be involved in vesicle trafficking; the structural integrity of HIP1 is crucial for maintenance of normal vesicle size in vivo. HIP12 is a non-proapoptotic member of the HIP gene family that is expressed in the brain and shares a similar subcellular distribution pattern with HIP1. However, HIP12 differs from HIP1 in its pattern of expression at both the mRNA and protein level. HIP12 does not directly interact with huntingtin but can interact with HIP1.
Catalog Number:
(10842-564)
Supplier:
HUMAN ACTIVE TECHNOLOGY, LLC
Description:
Free up desk space with the Winston workstation clamp mount accessory.
Catalog Number:
(89355-198)
Supplier:
Genetex
Description:
Rabbit Polyclonal antibody to Dyrk3 (dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3)
Catalog Number:
(10109-070)
Supplier:
Prosci
Description:
KIAA1333 is a probable E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.
Catalog Number:
(89356-624)
Supplier:
Genetex
Description:
Rabbit Polyclonal antibody to GSK3 beta (glycogen synthase kinase 3 beta)
Catalog Number:
(89356-064)
Supplier:
Genetex
Description:
Rabbit Polyclonal antibody to NPR-A (natriuretic peptide receptor A/guanylate cyclase A (atrionatriuretic peptide receptor A))
Catalog Number:
(10372-456)
Supplier:
Bioss
Description:
Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands. Phosphorylates PTK2/FAK1. Regulates both cell death/survival balance and positional information. Required for the molecular mechanisms orchestration during intestine organogenesis; involved in the development of enteric nervous system and renal organogenesis during embryonic life, and promotes the formation of Peyer's patch-like structures, a major component of the gut-associated lymphoid tissue. Modulates cell adhesion via its cleavage by caspase in sympathetic neurons and mediates cell migration in an integrin (e.g. ITGB1 and ITGB3)-dependent manner. Involved in the development of the neural crest. Active in the absence of ligand, triggering apoptosis through a mechanism that requires receptor intracellular caspase cleavage. Acts as a dependence receptor; in the presence of the ligand GDNF in somatotrophs (within pituitary), promotes survival and down regulates growth hormone (GH) production, but triggers apoptosis in absence of GDNF. Regulates nociceptor survival and size. Triggers the differentiation of rapidly adapting (RA) mechanoreceptors. Mediator of several diseases such as neuroendocrine cancers; these diseases are characterized by aberrant integrins-regulated cell migration.
Catalog Number:
(89296-458)
Supplier:
Genetex
Description:
Goat polyclonal antibody to BAG5
Catalog Number:
(89294-226)
Supplier:
Genetex
Description:
Goat polyclonal antibody to Syntenin 2
Catalog Number:
(89296-916)
Supplier:
Genetex
Description:
Goat polyclonal antibody to MEPCE
Catalog Number:
(89297-868)
Supplier:
Genetex
Description:
Goat polyclonal antibody to CASP4
Catalog Number:
(89296-006)
Supplier:
Genetex
Description:
Goat polyclonal antibody to ALDH3A1
Catalog Number:
(10110-626)
Supplier:
Prosci
Description:
TRIM48 belongs to the TRIM/RBCC family. It contains 1 B box-type zinc finger, 1 B30.2/SPRY domain and 1 RING-type zinc finger. The exact function of TRIM48 remains unknown.
Catalog Number:
(89357-178)
Supplier:
Genetex
Description:
Rabbit Polyclonal antibody to alpha Synuclein (synuclein, alpha (non A4 component of amyloid precursor))
Catalog Number:
(89349-742)
Supplier:
Genetex
Description:
Rabbit Polyclonal antibody to HSD3B2 (hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2)
Catalog Number:
(89297-672)
Supplier:
Genetex
Description:
Goat polyclonal antibody to GOLGA3
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