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chromatography+columns+HyClone+products+(Cytiva)
Catalog Number:
(10411-126)
Supplier:
Bioss
Description:
This gene generates several transcript variants which differ in their first exons. At least three alternatively spliced variants encoding distinct proteins have been reported, two of which encode structurally related isoforms known to function as inhibitors of CDK4 kinase. The remaining transcript includes an alternate first exon located 20 Kb upstream of the remainder of the gene; this transcript contains an alternate open reading frame (ARF) that specifies a protein which is structurally unrelated to the products of the other variants. This ARF product functions as a stabilizer of the tumor suppressor protein p53 as it can interact with, and sequester, the E3 ubiquitin-protein ligase MDM2, a protein responsible for the degradation of p53. In spite of the structural and functional differences, the CDK inhibitor isoforms and the ARF product encoded by this gene, through the regulatory roles of CDK4 and p53 in cell cycle G1 progression, share a common functionality in cell cycle G1 control. This gene is frequently mutated or deleted in a wide variety of tumors, and is known to be an important tumor suppressor gene. [provided by RefSeq, Sep 2012].
Catalog Number:
(10411-756)
Supplier:
Bioss
Description:
This gene generates several transcript variants which differ in their first exons. At least three alternatively spliced variants encoding distinct proteins have been reported, two of which encode structurally related isoforms known to function as inhibitors of CDK4 kinase. The remaining transcript includes an alternate first exon located 20 Kb upstream of the remainder of the gene; this transcript contains an alternate open reading frame (ARF) that specifies a protein which is structurally unrelated to the products of the other variants. This ARF product functions as a stabilizer of the tumor suppressor protein p53 as it can interact with, and sequester, the E3 ubiquitin-protein ligase MDM2, a protein responsible for the degradation of p53. In spite of the structural and functional differences, the CDK inhibitor isoforms and the ARF product encoded by this gene, through the regulatory roles of CDK4 and p53 in cell cycle G1 progression, share a common functionality in cell cycle G1 control. This gene is frequently mutated or deleted in a wide variety of tumors, and is known to be an important tumor suppressor gene. [provided by RefSeq, Sep 2012].
Catalog Number:
(10342-588)
Supplier:
Bioss
Description:
Receptor for interleukin-12. This subunit is the signaling component coupling to the JAK2/STAT4 pathway. Promotes the proliferation of T-cells as well as NK cells. Induces the promotion of T-cells towards the Th1 phenotype by strongly enhancing IFN-gamma production.
Catalog Number:
(10425-934)
Supplier:
Bioss
Description:
Hydrolyzes high molecular weight hyaluronic acid to produce an intermediate-sized product which is further hydrolyzed by sperm hyaluronidase to give small oligosaccharides. Displays very low levels of activity. Associates with and negatively regulates MST1R.
Catalog Number:
(10425-936)
Supplier:
Bioss
Description:
Hydrolyzes high molecular weight hyaluronic acid to produce an intermediate-sized product which is further hydrolyzed by sperm hyaluronidase to give small oligosaccharides. Displays very low levels of activity. Associates with and negatively regulates MST1R.
Catalog Number:
(10342-584)
Supplier:
Bioss
Description:
Receptor for interleukin-12. This subunit is the signaling component coupling to the JAK2/STAT4 pathway. Promotes the proliferation of T-cells as well as NK cells. Induces the promotion of T-cells towards the Th1 phenotype by strongly enhancing IFN-gamma production.
Catalog Number:
(10342-582)
Supplier:
Bioss
Description:
Receptor for interleukin-12. This subunit is the signaling component coupling to the JAK2/STAT4 pathway. Promotes the proliferation of T-cells as well as NK cells. Induces the promotion of T-cells towards the Th1 phenotype by strongly enhancing IFN-gamma production.
Catalog Number:
(10425-928)
Supplier:
Bioss
Description:
Hydrolyzes high molecular weight hyaluronic acid to produce an intermediate-sized product which is further hydrolyzed by sperm hyaluronidase to give small oligosaccharides. Displays very low levels of activity. Associates with and negatively regulates MST1R.
Supplier:
PRECISIONARY INSTRUMENTS LLC
Description:
Service plans for either a basic or premium compresstome training after a researcher receives the machine.
Supplier:
Bel-Art Products
Description:
These high-density polyethylene bottles with polypropylene screw closures store more samples or chemicals in limited shelf space than round bottles.
Catalog Number:
(77392-708)
Supplier:
CUBE BIOTECH
Description:
This product is a MSP nanodisc assembly kit. It contains a vial of lyophilized membrane scaffold protein MSP2N2 (His-tagged) and a vial of DMPC or POPC phopshospholipid to assemble a MSP nanodisc.
Supplier:
Puritan Medical Products
Description:
For use in critical environment cleaning
Catalog Number:
(10408-434)
Supplier:
Bioss
Description:
Binds IGF-I and IGF-II with a relatively low affinity. Stimulates prostacyclin (PGI2) production. Stimulates cell adhesion.
Supplier:
Bel-Art Products
Description:
A unique, 2-piece valve prevents pressure build-up of solvents within these Right-to-Know Safety-Labeled Wash Bottles, and allows dispensing with bottle upright or inverted.
Supplier:
HARDY DIAGNOSTICS CA
Description:
Mylar® Zip-bags contain a pre-weighed amount of dehydrated culture media sufficient to prepare two liters of finished product (after water is added). Criterion™ is designed to meet or exceed the highest standards.
Catalog Number:
(CAJT9444-05)
Supplier:
AVANTOR PERFORMANCE MATERIAL LLC
Description:
For high temperature gel permeation chromatography. UV cutoff at 310nm.
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