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chromatography+columns+HyClone+products+(Cytiva)
Catalog Number:
(10334-580)
Supplier:
Bioss
Description:
Catalyzes the methylation of glycine by using S-adenosylmethionine (AdoMet) to form N-methylglycine (sarcosine) with the concomitant production of S-adenosylhomocysteine (AdoHcy). Possible crucial role in the regulation of tissue concentration of AdoMet and of metabolism of methionine.
Catalog Number:
(10367-546)
Supplier:
Bioss
Description:
Glycolytic enzyme that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate (PEP) to ADP, generating ATP. Stimulates POU5F1-mediated transcriptional activation. Plays a general role in caspase independent cell death of tumor cells. The ratio betwween the highly active tetrameric form and nearly inactive dimeric form determines whether glucose carbons are channeled to biosynthetic processes or used for glycolytic ATP production. The transition between the 2 forms contributes to the control of glycolysis and is important for tumor cell proliferation and survival.
Catalog Number:
(MSPP-780841006)
Supplier:
Stemcell Technologies
Description:
Interleukin-8 (IL-8) is a member of the CXC subfamily of chemokines and is produced by leukocytic cells (monocytes, T cells, neutrophils, and natural killer cells) and non-leukocytic somatic cells (endothelial cells, fibroblasts, and epithelial cells), with the most prominent source being monocytes and macrophages. Its production is induced by inflammatory stimuli, such as IL-1. IL-8, also known as CXCL8, activates neutrophils inducing chemotaxis, exocytosis, and the respiratory burst (Baggiolini and Clark-Lewis; Mukaida). IL-8 is considered one of the most potent neutrophil chemoattractants in inflammation and binds to two different chemokine receptors on leukocytes: the G protein-coupled receptors CXCR1 and CXCR2 (Hoffmann <i>et al.</i>; de Oliveira <i>et al.</i>). IL-8 has angiogenic effects on human intestinal microvascular endothelial cells in vitro that are mediated by CXCR2 (Heidemann <i>et al.</i>). IL-8 is reported to promote breast cancer progression by increasing cell invasion, angiogenesis, and metastasis and has been reported to be involved in regulating breast cancer stem-like cells (Singh <i>et al.</i>). IL-8 also has proangiogenic properties in inflammatory diseases of the conjunctiva, cornea, iris, retina, and orbit (Ghasemi <i>et al.</i>). It was also shown that a major T cell effector function in human newborns is IL-8 production, which has the potential to activate antimicrobial neutrophils and gamma/delta T cells (Gibbons <i>et al.</i>). A variety of human pathogens, such as HIV and Mycobacterium tuberculosis, have been shown to induce IL-8 production by monocytes and macrophages (Friedland <i>et al.</i>; Meddows-Taylor <i>et al.</i>).
Catalog Number:
(470156-892)
Supplier:
Impact Products
Description:
The ProGuard® flock-lined Latex gloves are chemically resistant to mild detergents and acids, alkalis, fats, oils, and germicides. Embossed grip offers excellent abrasion resistance.
Catalog Number:
(50807-126)
Supplier:
Rheodyne
Description:
Select up to six columns for different analytical methods on the same instrument
Catalog Number:
(MSPP-780271006)
Supplier:
Stemcell Technologies
Description:
Interleukin 12 (IL-12p70) is a heterodimeric cytokine composed of p35 and p40 subunits. IL-12 is produced by monocytes, macrophages, dendritic cells, neutrophils, and B cells in response to bacterial products and cytokines such as IFN-γ. The IL-12 receptor is expressed on T, NK, and dendritic cells. Upon binding, IL-12 initiates signaling via the JAK/STAT signaling pathway and stimulates NK, B, and T cells to produce IFN-γ (Watford <i>et al.</i>). It also regulates cytokine synthesis, proliferation of T and NK cells, and stimulates differentiation of CD4+ and CD8+ T cells (Germann and Rüde). Mice that are deficient in IL-12 are susceptible to many intracellular pathogens and have impaired IFN-γ secretion, Th1 differentiation, and NK cytolytic activity; however, Th2 development and IL-4 production are enhanced (Watford <i>et al.</i>).
Supplier:
Electron Microscopy Sciences
Description:
Glennel® Diamond Suspension assures a consistent, uniform viscosity and dispersion of diamond without any shaking or stirring.
Catalog Number:
(RK30002)
Supplier:
Restek
Description:
Mix contains: (C9) n-Nonane (111-84-2), (C12) n-Dodecane (112-40-3).
Supplier:
Thermo Scientific
Description:
Save time and minimize the risk of cross-contamination with Thermo Scientific™ SureSTART™ Level 3 WebSeal™ 96-well plate sealing mats for well plate kits. Select SureSTART Level 3 products for ultimate performance and sensitivity from your methods while maintaining the highest levels of sample security and integrity.
Supplier:
Medegen Medical Products, LLC
Description:
These stainless steel bowls are easy to clean and have a no-spin recessed bottom
Supplier:
Wards
Description:
Designed for a variety of science laboratory uses.
Catalog Number:
(89317-736)
Supplier:
Genetex
Description:
Rabbit Polyclonal antibody to Cybr
Supplier:
Caron Products
Description:
Elevated humidity with water pan, for carbon dioxide incubators, model: 7401-25-3 & 7401-33-3, 230v 50Hz. factory installed at the time of order or can be retro-fitted in the field.
Catalog Number:
(H-3615.0001BA)
Supplier:
Bachem Americas
Description:
See also H-3974, H-Lys(4-nitro-Z)-pyrrolidide · HCl (N-1710) and H-Phe-pyrrolidide (E-3275).
Catalog Number:
(10427-404)
Supplier:
Bioss
Description:
Proto-oncogene AF-4 (or FEL) is a product of a chromosomal aberration of the human gene AFF1, which is associated with acute leukemias. The fusion of AF-4 on chromosome band 4q21 with the mixed lineage leukemia (MLL or HRX) gene on 11q23 results in a MLL-AF-4 chimeric transcription factor in which AF-4 contributes transcriptional effector properties and requires cell-specific accessory factors. MLL is involved in several chromosomal translocations associated with acute myeloid and lymphoid leukemia. The MLL-AF-4 fusion protein is expressed in all normal hematopoietic cells. The expression of MLL-AF-4 influences the production of protein cyclin-dependent kinase inhibitor (CDKN1B), suggesting that inhibition of MLL-AF-4 expression may be a powerful and highly specific treatment of chemotherapy-resistant leukemia.
Supplier:
Ace Glass
Description:
Raschig rings fabricated from borosilicate glass.
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