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chromatography+columns+HyClone+products+(Cytiva)
Catalog Number:
(10387-908)
Supplier:
Bioss
Description:
Gross cystic disease is a common premenopausal disorder in which gross cysts are the predominant pathologic lesion. It is characterized by production of a fluid secretion which accumulates in the breast cysts. Gross cystic disease fluid is a pathologic secretion from breast composed of several glycoproteins, including a unique 15 kDa monomer protein, GCDFP 15. The cells within the body that produce GCDFP 15 appear to be restricted primarily to those with apocrine function. Studies have found GCDFP 15 to be a highly specific and sensitive marker for breast cancer.
Catalog Number:
(RK21691)
Supplier:
Restek
Description:
Siltek® treatment makes weldment inert and eliminates adsorption of sensitive compounds (e.g., DDT and endrin).
Catalog Number:
(10095-724)
Supplier:
Proteintech
Description:
The product of TCF12 gene (TCF12, also called HTF4 or HEB) is a member of helix-loop-helix (HLH) protein family . TCF12 is a transcriptional regulator that involved in the initiation of neuronal differentiation. It 's also known as E proteins, and activates transcription by binding to the E box (5'-CANNTG-3'), because of their direct DNA (E-box) binding ability . TCF12 was shown to suppress E-cadherin expression during the early stages of renal tubular epithelial cell dedifferentiation .
Catalog Number:
(16126-656)
Supplier:
Bel-Art Products
Description:
Tefzel® Fluorocarbon plastic forceps have smooth square tips 1.6 mm (¹/₁₆") wide.
Catalog Number:
(76579-780)
Supplier:
Advanced Instruments
Description:
Increase your productivity and reliability with powerful freezing point depression technology for osmolality measurement with the OsmoTECH® XT single-sample osmometer.
Catalog Number:
(CA100219-190)
Supplier:
Teknova
Description:
This nutrient agar is used as a general purpose medium for the examination of water and dairy products. Also used for the cultivation of fastidious microorganisms.
Supplier:
Enzo Life Sciences
Description:
Small molecule STAT3-specific inhibitor which blocks activation, dimerization and nuclear translocation via binding to the STAT3 SH2 domain. It is a very useful tool for exploring STAT3-mediated signaling pathways. It blocks LPS-mediated STAT3 tyrosine phosphorylation which leads to inhibition of LPS-mediated IL-1β and IL-6 production. In primary cultures of rat neural stem cells it blocks IL-15-induced differentiation.
Supplier:
Bel-Art Products
Description:
These micro spatulas are made of stainless steel rod with flat ends coated in brown Teflon® FEP, which complies with FDA regulations governing direct food contact applications.
Supplier:
Optimize
Description:
OPTI-LOK Fittings are ideal for high-pressure connections with ¹/₁₆" OD tubing. All Optimize fittings are precision machined for optimal quality and thread consistency and are designed for trouble-free operation at pressures of up to 6,000 psi.
Catalog Number:
(76006-960)
Supplier:
Remco Products
Description:
This nylon flexible handle is used with a tube brush for cleaning around sensitive areas such as glass, and its flexibility allows it to follow curved pipes.
Supplier:
United Science
Description:
Heater, Recirculating, For P99, responsible for distilling solvents from chromatography mobile phase, Equipped with 5hp recirculator pump, voltage: 460V/3ph/60Hz
Catalog Number:
(53499-472)
Supplier:
DWK Life Sciences (KIMBLE)
Description:
The unique cone liner design offers superior torque retention and excellent sealing characteristics.
Catalog Number:
(76027-820)
Supplier:
Berkshire
Description:
The MicroSeal® VP- Mop Wiper is a sealed edge, laundered, knit wiper.
Catalog Number:
(10071-870)
Supplier:
Prosci
Description:
This is a calcium-independent, phospholipid-dependent, serine- and threonine-specific enzyme. Essential for T-cell receptor (TCR)-mediated T-cell activation, but is dispensable during TCR-dependent thymocyte development. Links the TCR signaling complex to the activation of NF-κ-B in mature T lymphocytes. Required for interleukin-2 (IL2) production. PKC is activated by diacylglycerol which in turn phosphorylates a range of cellular proteins. PKC also serves as the receptor for phorbol esters, a class of tumor promoters.
Supplier:
Shenandoah Biotechnology
Description:
Interleukin 33 (IL-33) is a member of the IL-1 cytokine family and is constitutively expressed in smooth muscle and airway epithelial cells. IL-33 signals through the interleukin 1 receptor-like 1 (IL-1R1) and interleukin-1 receptor accessory protein (IL1RAP) receptors to ativate NF-κB and MAPK signaling pathways. IL-33 functions to induce type 2 cytokine production in polarized Type 2 helper T (Th2) cells.
Catalog Number:
(89360-966)
Supplier:
Genetex
Description:
MDM2 is a nuclear phosphoprotein with an apparent molecular mass of 90 Kd that forms a complex with the p53 tumor suppressor protein. Human MDM2 was identified as a homologous product of the 'murine double minute 2' gene (mdm2). The MDM2 gene enhances the tumorigenic potential of cells when it is overexpressed and encodes a putative transcription factor. Forming a tight complex with the p53 gene, the MDM2 oncogene can inhibit p53-mediated transactivation. MDM2 binds to p53 and amplification of MDM2 in sarcomas leads to escape from p53-regulated growth control. This mechanism of tumorigenesis parallels that for virus-induced tumors in which viral oncogene products bind to and functionally inactivate p53. Overexpression of the MDM2 oncogene was found in leukemias. Inactivation of tumor suppressor genes leads to deregulated cell proliferation and is a key factor in human tumorigenesis. MDM2 interacts physically and functionally with the retinoblastoma (RB) protein and can inhibit its growth regulatory capacity. Both RB and p53 can be subjected to negative regulation by the product of a single cellular protooncogene. The interference of binding to p53 prevents the interaction of MDM2 and its regulation of the transcriptional activity of p53 in vivo. Direct association of p53 with the cellular protein MDM2 results in ubiquitination and subsequent degradation of p53. MDM2-p53 complexes were preferentially found in S/G2M phases of the cell cycle. MDM2 maps to 12q14.3-q15, distal to CDK4 and flanked by Genethon microsatellites D12S80 and D12S83. On both the physical and the genetic maps of chromosome 12, the IFG gene maps close to the locus of the MDM2 oncogene on 12q15. The MDM2 gene is alternatively spliced, producing 5 additional splice variant transcripts from the full length MDM2 gene. Four out of five of these alternatively spliced forms (MDM2a-MDMd) are missing substantial portions of the p53-binding domain and retain the acidic domain and the zinc-finger domains. The fifth and smallest transcript (MDM2e) retains the largest spliced region encoding the p53-binding domain; however, it lacks the nuclear localization signal, the acidic domain and zinc-finger domains. The alternatively spliced transcripts tend to be expressed in tumorigenic tissue, whereas the full length MDM2 transcript is expressed in normal tissue.
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