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chromatography+columns+HyClone+products+(Cytiva)
Catalog Number:
(72310-316)
Supplier:
Hamilton
Description:
Hamilton Company offers the most comprehensive selection of standard and custom syringes in the industry
Catalog Number:
(76510-080)
Supplier:
Genscript
Description:
The product is specific for trastuzumab. The antibody is recommended as a capture antibody in a pharmacokinetic (PK) bridging assay with detection antibody GenScript, A02033-40, anti-trastuzumab antibody (15H2), mAb, mouse.
Catalog Number:
(53499-472)
Supplier:
DWK Life Sciences (KIMBLE)
Description:
The unique cone liner design offers superior torque retention and excellent sealing characteristics.
Catalog Number:
(102101-534)
Supplier:
Electron Microscopy Sciences
Description:
Support Film on grids has become a main product line for us since the demand for high quality coated grids has increased. To make your microscopy work easier and to save you a great deal of time we offer you a complete line. All of our coated grids are optically checked followed by batch testing in the EM.
Catalog Number:
(10071-870)
Supplier:
Prosci
Description:
This is a calcium-independent, phospholipid-dependent, serine- and threonine-specific enzyme. Essential for T-cell receptor (TCR)-mediated T-cell activation, but is dispensable during TCR-dependent thymocyte development. Links the TCR signaling complex to the activation of NF-κ-B in mature T lymphocytes. Required for interleukin-2 (IL2) production. PKC is activated by diacylglycerol which in turn phosphorylates a range of cellular proteins. PKC also serves as the receptor for phorbol esters, a class of tumor promoters.
Catalog Number:
(89360-966)
Supplier:
Genetex
Description:
MDM2 is a nuclear phosphoprotein with an apparent molecular mass of 90 Kd that forms a complex with the p53 tumor suppressor protein. Human MDM2 was identified as a homologous product of the 'murine double minute 2' gene (mdm2). The MDM2 gene enhances the tumorigenic potential of cells when it is overexpressed and encodes a putative transcription factor. Forming a tight complex with the p53 gene, the MDM2 oncogene can inhibit p53-mediated transactivation. MDM2 binds to p53 and amplification of MDM2 in sarcomas leads to escape from p53-regulated growth control. This mechanism of tumorigenesis parallels that for virus-induced tumors in which viral oncogene products bind to and functionally inactivate p53. Overexpression of the MDM2 oncogene was found in leukemias. Inactivation of tumor suppressor genes leads to deregulated cell proliferation and is a key factor in human tumorigenesis. MDM2 interacts physically and functionally with the retinoblastoma (RB) protein and can inhibit its growth regulatory capacity. Both RB and p53 can be subjected to negative regulation by the product of a single cellular protooncogene. The interference of binding to p53 prevents the interaction of MDM2 and its regulation of the transcriptional activity of p53 in vivo. Direct association of p53 with the cellular protein MDM2 results in ubiquitination and subsequent degradation of p53. MDM2-p53 complexes were preferentially found in S/G2M phases of the cell cycle. MDM2 maps to 12q14.3-q15, distal to CDK4 and flanked by Genethon microsatellites D12S80 and D12S83. On both the physical and the genetic maps of chromosome 12, the IFG gene maps close to the locus of the MDM2 oncogene on 12q15. The MDM2 gene is alternatively spliced, producing 5 additional splice variant transcripts from the full length MDM2 gene. Four out of five of these alternatively spliced forms (MDM2a-MDMd) are missing substantial portions of the p53-binding domain and retain the acidic domain and the zinc-finger domains. The fifth and smallest transcript (MDM2e) retains the largest spliced region encoding the p53-binding domain; however, it lacks the nuclear localization signal, the acidic domain and zinc-finger domains. The alternatively spliced transcripts tend to be expressed in tumorigenic tissue, whereas the full length MDM2 transcript is expressed in normal tissue.
Supplier:
Hamilton
Description:
Hamilton Company offers the most comprehensive selection of standard and custom syringes in the industry
Catalog Number:
(470144-216)
Supplier:
United Scientific Supplies
Description:
This large plasmid model teaches students the basics of recombinant DNA technology.
Catalog Number:
(470313-344)
Supplier:
GSC International
Description:
These borosilicate glass burettes have a reinforced opening and are permanently graduated with subdivisions.
Catalog Number:
(10096-092)
Supplier:
Proteintech
Description:
TMEM173, also named as ERIS, MITA, STING and MPYS, is a facilitator of innate immune signaling that promotes the production of type I interferon (IFN-alpha and IFN-beta). TMEM173 mediates death signaling via activation of the extracellular signal-regulated kinase (ERK) pathway. There’re monomer (40 kDa) and dimer (80 kDa) form of TMEM173 in western blot test.
Catalog Number:
(89351-248)
Supplier:
Genetex
Description:
This gene encodes a tumor suppressor protein that includes among its many intracellular functions one of nuclear export. Defects in this gene cause familial adenomatous polyposis (FAP), an autosomal dominant pre-malignant disease that usually progresses to malignancy. Disease-associated mutations tend to be clustered in a small region designated the mutation cluster region (MCR) and result in a truncated protein product.
Supplier:
Hach
Description:
A product of decomposed plant material, tannin occurs in natural waters and is used for boiler and cooling tower water treatment, dyeing, ink manufacture, tanning, and paper sizing
Catalog Number:
(11216-422)
Supplier:
NASCO SAMPLING LLC
Description:
Blended, virgin polyethylene film provides exceptional clarity, superior strength, and sterilized after manufacturing for results you can trust. HACCP, EPA, USDA, FDA approved for food contact.
Catalog Number:
(66190-080)
Supplier:
Bel-Art Products
Description:
This pipetting device can aspirate or dispense 96 wells in less than 10 seconds.
Supplier:
Ahlstrom
Description:
Ahlstrom Grade 642 is a thin chromatography paper with a slower flow rate for higher resolution
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 is still displayed and you need assistance, please call us at 1-800-932-5000.
Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the
is still displayed and you need assistance, please call us at 1-800-932-5000.
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