chromatography+columns+HyClone+products+(Cytiva)
Supplier:
MicroSolv Technology Corp
Catalog Number:
(30181-753)
Supplier:
Bel-Art Products
Description:
The translucent polypropylene plastic hood is non-conductive, chemical-resistant and corrosion-proof.
Catalog Number:
(10487-982)
Supplier:
Bioss
Description:
Polyadenylation of the 3-prime ends of eukaryotic mRNAs is a key event that takes place in the nucleus during maturation of mRNA. The reaction includes endoribonucleolytic cleavage of the pre-RNA at the poly(A) site that leads to synthesis of the poly(A) tail at the 3-prime end of the upstream cleavage product. The poly(A) polymerase (PAP) is required The adenosine addition reaction depends on poly(A) polymerase (PAP) activity. The testis express PAP-beta (TPAP) in the cytoplasm of spermatogenic cells. The adenosine addition function of PAP-beta plays a critical role in male germ cell production. PAP-beta-deficient transgenic mice display impaired expression of haploid-specific genes that are necessary for spermatogenesis. The intronless gene encoding human PAP-beta maps to chromosome 7p22.3.
Supplier:
Rheodyne
Description:
For Rheodyne® injector models 7125 and 7010.
Catalog Number:
(10427-406)
Supplier:
Bioss
Description:
Proto-oncogene AF-4 (or FEL) is a product of a chromosomal aberration of the human gene AFF1, which is associated with acute leukemias. The fusion of AF-4 on chromosome band 4q21 with the mixed lineage leukemia (MLL or HRX) gene on 11q23 results in a MLL-AF-4 chimeric transcription factor in which AF-4 contributes transcriptional effector properties and requires cell-specific accessory factors. MLL is involved in several chromosomal translocations associated with acute myeloid and lymphoid leukemia. The MLL-AF-4 fusion protein is expressed in all normal hematopoietic cells. The expression of MLL-AF-4 influences the production of protein cyclin-dependent kinase inhibitor (CDKN1B), suggesting that inhibition of MLL-AF-4 expression may be a powerful and highly specific treatment of chemotherapy-resistant leukemia.
Supplier:
Restek
Description:
Use of these liners helps ensure an inert GC flow path for higher sensitivity, accuracy, and reproducibility.
Catalog Number:
(CA95020-276)
Supplier:
HiMedia
Description:
For the selective enumeration of yeasts and molds in milk and milk products.
Supplier:
Bel-Art Products
Description:
Low-density polyethylene bottles and spouts have sealer caps that snap on easily for a tight seal.
Supplier:
Bel-Art Products
Description:
The ATS Life Sciences Bel-Art Secador® 5.0 Desiccator Cabinets provide dry storage for humidity-sensitive products such as laboratory samples, reagents, optical equipment, electronics, and 3D printing filament. Available in two configurations, a non-electric model that can be used with any Bel-Art desiccant and an electric model that is desiccant-free.
Catalog Number:
(10447-674)
Supplier:
Bioss
Description:
The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.
Catalog Number:
(10391-138)
Supplier:
Bioss
Description:
Galactokinase is a major enzyme for the metabolism of galactose and its deficiency causes congenital cataracts in the adult population. GALK1 sequence shares the greatest level of conservation, 44.5% identity with that from E. coli and 34.6% amino acid identity with the product of the human GALK2 gene.
Catalog Number:
(89085-134)
Supplier:
Ampac Flexibles
Description:
Ampac's FoilPAK (Non-Autoclave) pouches provide the best oxygen and moisture barrier available.
Supplier:
Steris
Description:
CIP 100® detergent is a proprietary blend of potassium hydroxide, an advanced surfactant system and other performance-enhancing ingredients that provide multiple cleaning mechanisms. This low foaming product removes a wide range of process residues, from fermentation by-products to silicone-based emulsions and lubricants, and is ideal for use in clean-in-place (CIP), clean-out-of-place (COP) and manual applications.
Catalog Number:
(75790-556)
Supplier:
Prosci
Description:
Programmed cell death protein 1(PDCD1) is a single-pass type I membrane protein and contains 1 Ig-like V-type domain. PD-1 is a member of the extended CD28/CTLA-4 family of T cell regulators. PDCD1 inhibits the T-cell proliferation and production of related cytokines including IL-1, IL-4, IL-10 and IFN- gamma by suppressing the activation and transduction of PI3K/AKT pathway. In addition, coligation of PDCD1 inhibits BCR-mediating signal by dephosphorylating key signal transducer. PDCD1 has been suggested to be involved in lymphocyte clonal selection and peripheral tolerance, and thus contributes to the prevention of autoimmune diseases. As a cell surface molecule, PDCD1 regulates the adaptive immune response. Engagement of PD-1 by its ligands PD-L1 or PD-L2 transduces a signal that inhibits T-cell proliferation, cytokine production, and cytolytic function.
Catalog Number:
(75791-908)
Supplier:
Prosci
Description:
Programmed cell death protein 1(PDCD1) is a single-pass type I membrane protein and contains 1 Ig-like V-type domain. PD-1 is a member of the extended CD28/CTLA-4 family of T cell regulators. PDCD1 inhibits the T-cell proliferation and production of related cytokines including IL-1, IL-4, IL-10 and IFN- gamma by suppressing the activation and transduction of PI3K/AKT pathway. In addition, coligation of PDCD1 inhibits BCR-mediating signal by dephosphorylating key signal transducer. PDCD1 has been suggested to be involved in lymphocyte clonal selection and peripheral tolerance, and thus contributes to the prevention of autoimmune diseases. As a cell surface molecule, PDCD1 regulates the adaptive immune response. Engagement of PD-1 by its ligands PD-L1 or PD-L2 transduces a signal that inhibits T-cell proliferation, cytokine production, and cytolytic function.
Catalog Number:
(102980-142)
Supplier:
Adipogen
Description:
IL-36Ra/IL-1F5 is a highly and a specific antagonist of the IL-1 receptor-related protein 2-mediated response to IL-36alpha (IL-1F6), IL-36beta (IL-1F8) and IL-36gamma (IL-1F9). These cytokines bind to IL-36R (IL-1Rrp2) and IL-1RAcP, activating similar intracellular signals as IL-1. IL-36Ra inhibits the production of proinflammatory cytokines, including IL-12, IL-1beta, IL-6, TNF-alpha and IL-23 induced by IL-36 in BMDC and CD4 T cells. Skin and dendritic cells are target of the IL-36 interleukins leading to a Th1 response. Recently mutations that affect the levels and the activity of IL-36Ra have been found in patients with pustular psoriasis, leading to enhanced production of inflammatory cytokines (IL-8 in particular) by keratinocytes.
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