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chromatography+columns+HyClone+products+(Cytiva)
Catalog Number:
(10071-870)
Supplier:
Prosci
Description:
This is a calcium-independent, phospholipid-dependent, serine- and threonine-specific enzyme. Essential for T-cell receptor (TCR)-mediated T-cell activation, but is dispensable during TCR-dependent thymocyte development. Links the TCR signaling complex to the activation of NF-κ-B in mature T lymphocytes. Required for interleukin-2 (IL2) production. PKC is activated by diacylglycerol which in turn phosphorylates a range of cellular proteins. PKC also serves as the receptor for phorbol esters, a class of tumor promoters.
Catalog Number:
(89138-170)
Supplier:
Biotium
Description:
Nitric oxide donors, nitric oxide synthase inhibitors, and nitric oxide detection reagents and kits.
Catalog Number:
(89360-966)
Supplier:
Genetex
Description:
MDM2 is a nuclear phosphoprotein with an apparent molecular mass of 90 Kd that forms a complex with the p53 tumor suppressor protein. Human MDM2 was identified as a homologous product of the 'murine double minute 2' gene (mdm2). The MDM2 gene enhances the tumorigenic potential of cells when it is overexpressed and encodes a putative transcription factor. Forming a tight complex with the p53 gene, the MDM2 oncogene can inhibit p53-mediated transactivation. MDM2 binds to p53 and amplification of MDM2 in sarcomas leads to escape from p53-regulated growth control. This mechanism of tumorigenesis parallels that for virus-induced tumors in which viral oncogene products bind to and functionally inactivate p53. Overexpression of the MDM2 oncogene was found in leukemias. Inactivation of tumor suppressor genes leads to deregulated cell proliferation and is a key factor in human tumorigenesis. MDM2 interacts physically and functionally with the retinoblastoma (RB) protein and can inhibit its growth regulatory capacity. Both RB and p53 can be subjected to negative regulation by the product of a single cellular protooncogene. The interference of binding to p53 prevents the interaction of MDM2 and its regulation of the transcriptional activity of p53 in vivo. Direct association of p53 with the cellular protein MDM2 results in ubiquitination and subsequent degradation of p53. MDM2-p53 complexes were preferentially found in S/G2M phases of the cell cycle. MDM2 maps to 12q14.3-q15, distal to CDK4 and flanked by Genethon microsatellites D12S80 and D12S83. On both the physical and the genetic maps of chromosome 12, the IFG gene maps close to the locus of the MDM2 oncogene on 12q15. The MDM2 gene is alternatively spliced, producing 5 additional splice variant transcripts from the full length MDM2 gene. Four out of five of these alternatively spliced forms (MDM2a-MDMd) are missing substantial portions of the p53-binding domain and retain the acidic domain and the zinc-finger domains. The fifth and smallest transcript (MDM2e) retains the largest spliced region encoding the p53-binding domain; however, it lacks the nuclear localization signal, the acidic domain and zinc-finger domains. The alternatively spliced transcripts tend to be expressed in tumorigenic tissue, whereas the full length MDM2 transcript is expressed in normal tissue.
Catalog Number:
(RK31450)
Supplier:
Restek
Description:
EPA method 8330 is used to measure explosives residues in water and soil samples, using HPLC with UV detection. Target analytes are nitroaromatic and nitramine explosives and their degradation products. Obtaining pure, neat compounds for Method 8330 reference standards can be very difficult. To ensure the highest quality standards, Restek's Quality Control (QC) lab confirms the identity and purity of mixture components and solvents using one or more of the following techniques: GC-FID, HPLC, GC-ECD, GC-MS, LC-MS, refractive index, and melting point.
Supplier:
Thermo Fisher Scientific
Description:
The TSX high-performance chromatography refrigerators are designed for a variety of applications requiring close temperature control, full access to chromatography instrumentation, and easy set-up of instrumentation and apparatus within the chamber. The TSX chromatography series features industry-leading safety features to ensure maximum protection.
Catalog Number:
(76510-100)
Supplier:
Genscript
Description:
The product is specific for infliximab. The antibody is recommended as a capture antibody in a pharmacokinetic (PK) bridging assay with detection antibody GenScript, A02041-40, anti-infliximab antibody (23H5), mAb, mouse.
Catalog Number:
(CA610-446-042)
Supplier:
Rockland Immunochemical
Description:
This product is designed for immunofluorescence microscopy, fluorescence based plate assays (FLISA), fluorescent western blotting and is also suitable for multiplex analysis with multicolor imaging.
Supplier:
Perfex
Description:
These long, narrow brushes are designed to reach inaccessible areas. Quickly remove fine dust, dirt, and other debris.
Supplier:
Bachem Americas
Description:
Antimicrobial peptides are produced by plants and most organisms throughout the animal kingdom including humans. Antimicrobial peptides protect against a broad range of infectious agents, as bacteria, fungi, and viruses. The amphibian skin is an especially rich source of antimicrobial peptides. See also the product families: Hepcidins LL-37 and Fragments Tuftsin and Analogs (subfamily).
Catalog Number:
(10071-828)
Supplier:
Prosci
Description:
Keratin 8 is a member of the type II keratin family clustered on the long arm of chromosome 12. Type I and type II keratins heteropolymerize to form intermediate-sized filaments in the cytoplasm of epithelial cells. The product of this gene typically dimerizes with keratin 18 to form an intermediate filament in simple single-layered epithelial cells. This protein plays a role in maintaining cellular structural integrity and also functions in signal transduction and cellular differentiation. Mutations in this gene cause cryptogenic cirrhosis.
Catalog Number:
(10068-514)
Supplier:
Prosci
Description:
The protein encoded by Cyclin B1 is a regulatory protein involved in mitosis. The gene product complexes with p34(cdc2) to form the maturation-promoting factor (MPF). Two alternative transcripts have been found, a constitutively expressed transcript and a cell cycle-regulated transcript, that is expressed predominantly during G2/M phase. The different transcripts result from the use of alternate transcription initiation sites.
Catalog Number:
(29876-001)
Supplier:
Bel-Art Products
Description:
Highly visible nylon indicator ball is housed in clear polycarbonate and rotates in circular channel during flow providing immediate visual indication of water/liquid flow.
Supplier:
Caron Products
Description:
Caron's new 7350-Series Animal Rearing Chambers provide the results users need, without all the usual hassle.
Supplier:
Puritan Medical Products
Description:
For use in specimen collection, wound care, application of topical dressings, cosmetic applications/tattoos, or general purpose
Supplier:
Ahlstrom
Description:
Ahlstrom Grade 222 is a 100% cotton medium thick chromatography paper with a smooth and uniform texture
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