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chromatography+columns+HyClone+products+(Cytiva)
Supplier:
Spectrum Chemicals
Description:
BHT, Granular, FCC is used in small quantities as a food additive as an antioxidant. Spectrum Chemical offers over 300 Food Grade (FCC) chemical ingredients packaged in laboratory size bottles to production drum quantities and are manufactured, packaged and stored under current Good Manufacturing Practices (cGMP) per 21CFR part 211 in FDA registered and inspected facilities
Supplier:
G-Biosciences
Description:
PAGE-Optimizer is a unique, spin column for the preparation of samples for SDS-PAGE. The columns contain a proprietary separation matrix that removes contaminants such as salts, detergents, cellular agents and other common buffering agents.
Supplier:
Ansell Healthcare
Description:
These polyethylene pharma covers provide product protection from environmental impurities during storage, processing and transportation.
Supplier:
SPEX CERTIPREP LLC
Description:
Ion chromatography and ion selective electrode standards.
Catalog Number:
(CAPI34005)
Supplier:
LIFE TECHNOLOGIES CORP CA
Description:
Thermo Scientific Pierce OPD is a water-soluble substrate for horseradish peroxidase (HRP) that produces a yellow-orange product detectable at 492nm by ELISA plate readers.
Supplier:
AGILENT TECHNOLOGIES, INC (CSD) CA
Description:
Our unique, stainless steel, self-tightening GC column nuts deliver tight connections with no expensive upgrades or adaptors needed.
Catalog Number:
(10071-870)
Supplier:
Prosci
Description:
This is a calcium-independent, phospholipid-dependent, serine- and threonine-specific enzyme. Essential for T-cell receptor (TCR)-mediated T-cell activation, but is dispensable during TCR-dependent thymocyte development. Links the TCR signaling complex to the activation of NF-κ-B in mature T lymphocytes. Required for interleukin-2 (IL2) production. PKC is activated by diacylglycerol which in turn phosphorylates a range of cellular proteins. PKC also serves as the receptor for phorbol esters, a class of tumor promoters.
Catalog Number:
(103006-282)
Supplier:
Anaspec Inc
Description:
Angiotensin or Ang (1-7), DRVYIHP, is a cleavage product from either Angiotensin (Ang) I or Angiotensin (Ang) II. Ang (1-7) acts as a vasodilator, inhibitor of protein synthesis or as a natriuretic agent. Ang (1-7) acts through its G-protein coupled receptor, Mas.
Sequence: DRVYIHP MW: 899 Da % Peak area by HPLC: 95 Storage condition: -20°C
Supplier:
ACCUFORM MANUFACTURING, INC
Description:
Floor signs alert and remind those to practice social and physical distancing to prevent the spread of COVID-19, the Coronavirus.
Supplier:
Enzo Life Sciences
Description:
Small molecule STAT3-specific inhibitor which blocks activation, dimerization and nuclear translocation via binding to the STAT3 SH2 domain. It is a very useful tool for exploring STAT3-mediated signaling pathways. It blocks LPS-mediated STAT3 tyrosine phosphorylation which leads to inhibition of LPS-mediated IL-1β and IL-6 production. In primary cultures of rat neural stem cells it blocks IL-15-induced differentiation.
Catalog Number:
(89360-966)
Supplier:
Genetex
Description:
MDM2 is a nuclear phosphoprotein with an apparent molecular mass of 90 Kd that forms a complex with the p53 tumor suppressor protein. Human MDM2 was identified as a homologous product of the 'murine double minute 2' gene (mdm2). The MDM2 gene enhances the tumorigenic potential of cells when it is overexpressed and encodes a putative transcription factor. Forming a tight complex with the p53 gene, the MDM2 oncogene can inhibit p53-mediated transactivation. MDM2 binds to p53 and amplification of MDM2 in sarcomas leads to escape from p53-regulated growth control. This mechanism of tumorigenesis parallels that for virus-induced tumors in which viral oncogene products bind to and functionally inactivate p53. Overexpression of the MDM2 oncogene was found in leukemias. Inactivation of tumor suppressor genes leads to deregulated cell proliferation and is a key factor in human tumorigenesis. MDM2 interacts physically and functionally with the retinoblastoma (RB) protein and can inhibit its growth regulatory capacity. Both RB and p53 can be subjected to negative regulation by the product of a single cellular protooncogene. The interference of binding to p53 prevents the interaction of MDM2 and its regulation of the transcriptional activity of p53 in vivo. Direct association of p53 with the cellular protein MDM2 results in ubiquitination and subsequent degradation of p53. MDM2-p53 complexes were preferentially found in S/G2M phases of the cell cycle. MDM2 maps to 12q14.3-q15, distal to CDK4 and flanked by Genethon microsatellites D12S80 and D12S83. On both the physical and the genetic maps of chromosome 12, the IFG gene maps close to the locus of the MDM2 oncogene on 12q15. The MDM2 gene is alternatively spliced, producing 5 additional splice variant transcripts from the full length MDM2 gene. Four out of five of these alternatively spliced forms (MDM2a-MDMd) are missing substantial portions of the p53-binding domain and retain the acidic domain and the zinc-finger domains. The fifth and smallest transcript (MDM2e) retains the largest spliced region encoding the p53-binding domain; however, it lacks the nuclear localization signal, the acidic domain and zinc-finger domains. The alternatively spliced transcripts tend to be expressed in tumorigenic tissue, whereas the full length MDM2 transcript is expressed in normal tissue.
Catalog Number:
(10447-852)
Supplier:
Bioss
Description:
Catalyzes the formation of 25-hydroxycholesterol from cholesterol, leading to repress cholesterol biosynthetic enzymes. May play an important role in regulating lipid metabolism by synthesizing a corepressor that blocks sterol regulatory element binding protein (SREBP) processing. In testis, production of 25-hydroxycholesterol by macrophages may play a role in Leydig cell differentiation.
Supplier:
Puritan Medical Products
Description:
Ideal for use as a cleaning swab for fiber optics, wafers, and disk drives
Supplier:
Kinematica
Description:
Standard dispersing generators come with the EC (EasyClean) design and rotor/stator geometries with two, four or six teeth rows. This is all you need for popular applications in the preparation of samples, formulation development and small-scale production. Dispersing generators are made from high-alloy stainless steel 316L, electropolished, Ra≤1.6 μm as standard.
Supplier:
Bachem Americas
Description:
Antimicrobial peptides are produced by plants and most organisms throughout the animal kingdom including humans. Antimicrobial peptides protect against a broad range of infectious agents, as bacteria, fungi, and viruses. The amphibian skin is an especially rich source of antimicrobial peptides. See also the product families: Hepcidins LL-37 and Fragments Tuftsin and Analogs (subfamily).
Catalog Number:
(10765-870)
Supplier:
Prosci
Description:
The HTA125 monoclonal antibody specifically reacts with human CD284, a 110kDA type I transmembrane signaling molecule known as the Toll-like Receptor 4 (TLR4). CD284 is an important molecule in the innate immunity response to bacterial lipoproteins. It is expressed by monocytes, macrophages, and endothelial cells. The HTA125 antibody can block Lipopolysaccharide-induced cytokine production and immunoprecipitate human TLR4.
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