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chromatography+columns+HyClone+products+(Cytiva)
Catalog Number:
(77437-258)
Supplier:
Bioss
Description:
Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFA, VEGFC and VEGFD. Plays an essential role in the regulation of angiogenesis, vascular development, vascular permeability, and embryonic hematopoiesis. Promotes proliferation, survival, migration and differentiation of endothelial cells. Promotes reorganization of the actin cytoskeleton. Isoforms lacking a transmembrane domain, such as isoform 2 and isoform 3, may function as decoy receptors for VEGFA, VEGFC and/or VEGFD. Isoform 2 plays an important role as negative regulator of VEGFA-and VEGFC-mediated lymphangiogenesis by limiting the amount of free VEGFA and/or VEGFC and preventing their binding to FLT4. Modulates FLT1 and FLT4 signaling by forming heterodimers. Binding of vascular growth factors to isoform 1 leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate and the activation of protein kinase C. Mediates activation of MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Mediates phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, reorganization of the actin cytoskeleton and activation of PTK2/FAK1. Required for VEGFA-mediated induction of NOS2 and NOS3, leading to the production of the signaling molecule nitric oxide (NO) by endothelial cells. Phosphorylates PLCG1. Promotes phosphorylation of FYN, NCK1, NOS3, PIK3R1, PTK2/FAK1 and SRC.
Catalog Number:
(CA200-301-A99)
Supplier:
Rockland Immunochemical
Description:
Has been tested for use in Western Blot, Immunohistochemistry and ELISA. 100ug Related Product Western Blotting Kit RLKCA002
Supplier:
Ace Glass
Description:
Standard headspace vials with 20 mm finish neck for crimp seals.
Supplier:
TCI America
Description:
[Reagent for Ion-Pair Chromatography]
CAS Number: 1643-19-2 MDL Number: MFCD00011633 Molecular Formula: C16H36BrN Molecular Weight: 322.38 Purity/Analysis Method: >99.0% (T) Form: Crystal Melting point (°C): 103
Catalog Number:
(77436-688)
Supplier:
Bioss
Description:
Nitric oxide (NO) is an inorganic, gaseous free radical that carries a variety of messages between cells. Vasorelaxation, neurotransmission and cytotoxicity can all be potentiated through cellular response to NO. NO production is mediated by members of the nitric oxide synthase (NOS) family. NOS catalyzes the oxidization of L-arginine to produce L-citrulline and NO. Two constitutive isoforms, brain or neuronal NOS (b or nNOS, type I) and endothelial cell NOS (eNOS, type III), and one inducible isoform (iNOS, type II), have been cloned. All NOS isoforms contain calmodulin, nicotinamide adenine dinucleotide phosphate (NADPH), flavin adenine dinucleotide (FAD), and flavin mononucleotide (FMN) binding domains. Nitric oxide synthase is expressed in liver, macrophages, hepatocytes, synoviocytes, stimulated glial cells and smooth muscle cells. Cytokines such as interferon-gamma (IFN), tumor necrosis factor (TNF), interleukin-1 and -2, and lipopolysaccarides (LPS) cause an increase in iNOS mRNA, protein, and activity levels. Protein kinase C-stimulating agents exhibit the same effect on iNOS activity. After cytokine induction, iNOS exhibits a delayed activity response which is then followed by a significant increase in NO production over a long period of time. Human iNOS is regulated by calcium/calmodulin (in contrast with mouse NOS₂).
Catalog Number:
(CA101099-998)
Supplier:
Omni International
Description:
The Omni Mixer Homogenizer is a versatile system that is well suited for laboratory & industrial processing applications such as Food, Cosmetics, Chemicals, Petrochemicals, Dyes and Waste Products.
Catalog Number:
(76108-296)
Supplier:
Bioss
Description:
FAM36A is a multi-pass membrane protein. It belongs to the FAM36 family. The exact function of FAM36A remains unknown.Chromosome 1 is the largest human chromosome spanning about 260 million base pairs and making up 8% of the human genome. There are about 3,000 genes on chromosome 1, and considering the great number of genes there are also a large number of diseases associated with chromosome 1. Notably, the rare aging disease Hutchinson-Gilford progeria is associated with the LMNA gene which encodes lamin A. When defective, the LMNA gene product can build up in the nucleus and cause characteristic nuclear blebs. The mechanism of rapidly enhanced aging is unclear and is a topic of continuing exploration. The MUTYH gene is located on chromosome 1 and is partially responsible for familial adenomatous polyposis. Stickler syndrome, Parkinsons, Gaucher disease and Usher syndrome are also associated with chromosome 1. A breakpoint has been identified in 1q which disrupts the DISC1 gene and is linked to schizophrenia. Aberrations in chromosome 1 are found in a variety of cancers including head and neck cancer, malignant melanoma and multiple myeloma. The FAM36A gene product has been provisionally designated FAM36A pending further characterization.
Catalog Number:
(89064-064)
Supplier:
Ace Glass
Description:
REPLACEMENT CAPS, 20ML SIZE, OPEN-TOP PTFE-FACED, CS/200, w240518.
Supplier:
KEYSTONE ADJUSTABLE CAP CO., INC.
Description:
1073B Tyvek® are ideal for steam sterilization of pharmaceutical components such as vial and syringe stoppers and caps as well as heavy equipment parts with sharp edges.
Supplier:
SPEX CERTIPREP LLC
Description:
Ion chromatography and ion selective electrode standards.
Supplier:
Thermo Scientific Chemicals
Description:
For synthesis of optically active products
Supplier:
Bel-Art Products
Description:
Protecting valuable humidity-sensitive items, such as reagents or electronics, is easy and fully automatic with Secador® Auto-Desiccator Cabinets.
Catalog Number:
(56620-658)
Supplier:
New Pig
Description:
Durable polyurethane plug forms a liquid-tight, chemical-resistant seal in seconds.
Supplier:
Bel-Art Products
Description:
Digital verification thermometers verify sample temperatures inside refrigerators and incubators without the use of a cable.
Supplier:
Hamilton
Description:
Hamilton Company offers the most comprehensive selection of standard and custom syringes in the industry
Catalog Number:
(76468-272)
Supplier:
Contec
Description:
ReFIBE wipes are made from 100% recycled plastic bottles, making them a sustainable single-use option for critical manufacturers in the life sciences, pharmaceutical, medical device, and semi-conductor industries. The revolutionary recycling process converts post-consumer plastic to 100% continuous filament polyester, the same substrate used in many of standard polyester wipes and mops.
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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the
is still displayed and you need assistance, please call us at 1-800-932-5000.
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