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chromatography+columns+HyClone+products+(Cytiva)
Catalog Number:
(CA700002-122)
Supplier:
Spectrum Chemicals
Description:
Boiling Chips, also known as boiling stones, are tiny pieces of an inert substance added to certain liquids to help them boil more calmly. Ungraded products supplied by Spectrum are indicative of a grade suitable for general industrial use or research purposes and typically are not suitable for human consumption or therapeutic use. These materials may or may not have a Certificate of Analysis available.
Catalog Number:
(10666-198)
Supplier:
Bioss
Description:
Calcium-activated non selective (CAN) cation channel that mediates membrane depolarization. While it is activated by increase in intracellular Ca(2+), it is impermeable to it. Mediates transport of monovalent cations (Na(+) >K(+) >Cs(+) >Li(+)), leading to depolarize the membrane. It thereby plays a central role in cadiomyocytes, neurons from entorhinal cortex, dorsal root and vomeronasal neurons, endocrine pancreas cells, kidney epithelial cells, cochlea hair cells etc. Participates in T-cell activation by modulating Ca(2+) oscillations after T lymphocyte activation, which is required for NFAT-dependent IL2 production. Involved in myogenic constriction of cerebral arteries. Controls insulin secretion in pancreatic beta-cells. May also be involved in pacemaking or could cause irregular electrical activity under conditions of Ca(2+) overload. Affects T-helper 1 (Th1) and T-helper 2 (Th2) cell motility and cytokine production through differential regulation of calcium signaling and NFATC1 localization. Enhances cell proliferation through up-regulation of the beta-catenin signaling pathway.Involvement in disease:Defects in TRPM4 are the cause of progressive familial heart block type 1B (PFHB1B) [MIM:604559]. It is a cardiac bundle branch disorder characterized by progressive alteration of cardiac conduction through the His-Purkinje system, with a pattern of a right bundle-branch block and/or left anterior hemiblock occurring individually or together. It leads to complete atrio-ventricular block causing syncope and sudden death.
Supplier:
PeproTech, Inc.
Description:
Proteases (also called Proteolytic Enzymes, Peptidases, or Proteinases) are enzymes that hydrolyze the amide bonds within proteins or peptides. Most proteases act in a specific manner, hydrolyzing bonds at, or adjacent to, specific residues, or a specific sequence of residues contained within the substrate protein or peptide. Proteases play an important role in most diseases and biological processes, including prenatal and postnatal development, reproduction, signal transduction, immune response, various autoimmune and degenerative diseases, and cancer. They are also an important research tool, as they are frequently used in the analysis and production of proteins. Glu-C cleaves at the Carboxyl side of E (can also cleave D under certain conditions). Recombinant Staphylococcus Glu-C is a 28.8 kDa protease consisting of 266 amino acid residues.
Catalog Number:
(10073-090)
Supplier:
Prosci
Description:
The IL-1 family is comprised of 11 structurally related ligands, including recently re-named IL-36α (IL-1F6), β (IL-1F8) and γ (IL-1F9). IL-36β is highly expressed in psoriatic plaques, and at lower levels in various other tissues. IL-36β signals through the IL-1Rrp2 (IL-1R6) receptor, which is primarily expressed on certain dendritic cells. The interaction of the IL-1Rrp2 receptor with IL-36 ligands induces dendritic cell maturation and activation. IL-36β also functions as an agonist of NF-kappaB, and stimulates the production of pro-inflammatory proteins, including IL-6, IL-8, BD-2, and BD-3. Recombinant human IL-36β is a 17.3 kDa protein containing 154 amino acid residues.
Supplier:
Caron Products
Description:
With full visible and UVA ICH Q1B exposures in as little as 42 hours, the 7450 series provides results fast. Many competing chambers take 2 to 3 times as long. Fast photoexposure allows users to test more samples, reducing drug development time, and saving money.
Catalog Number:
(77439-738)
Supplier:
Bioss
Description:
ATP-dependent RNA helicase required during spermatogenesis (PubMed:10920202, PubMed:21034600). Required to repress transposable elements and preventing their mobilization, which is essential for the germline integrity (By similarity). Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons (By similarity). Involved in the secondary piRNAs metabolic process, the production of piRNAs in fetal male germ cells through a ping-pong amplification cycle (By similarity). Required for PIWIL2 slicing-triggered piRNA biogenesis: helicase activity enables utilization of one of the slice cleavage fragments generated by PIWIL2 and processing these pre-piRNAs into piRNAs (By similarity).
Catalog Number:
(89323-320)
Supplier:
Genetex
Description:
Purity: Purified by antigen-affinity chromatography. Species Reactivity: Human Tested Applications: IHC-P, WB Pkg Size: 100 ul
Catalog Number:
(89330-938)
Supplier:
Genetex
Description:
Purity: Purified by antigen-affinity chromatography. Species Reactivity: Human Tested Applications: IHC-P, WB Pkg Size: 100 ul
Catalog Number:
(89323-734)
Supplier:
Genetex
Description:
Purity: Purified by antigen-affinity chromatography. Species Reactivity: Human Tested Applications: ICC/IF, WB Pkg Size: 100 ul
Catalog Number:
(89322-736)
Supplier:
Genetex
Description:
Purity: Purified by antigen-affinity chromatography. Species Reactivity: Human Tested Applications: IHC-P, WB Pkg Size: 100 ul
Catalog Number:
(89321-666)
Supplier:
Genetex
Description:
Purity: Purified by antigen-affinity chromatography. Species Reactivity: Human, Mouse Tested Applications: WB Pkg Size: 100 ul
Catalog Number:
(89323-746)
Supplier:
Genetex
Description:
Purity: Purified by antigen-affinity chromatography. Species Reactivity: Human Tested Applications: IHC-P, WB Pkg Size: 100 ul
Catalog Number:
(76120-344)
Supplier:
Bioss
Description:
The smallest of the human chromosomes, 21 makes up about 1.5% of the human genome. Chromosome 21 contains nearly 300 genes and 47 million base pairs. Down syndrome, also known as trisomy 21, is the disease most commonly associated with chromosome 21. Alzheimer's disease, Jervell and Lange-Nielsen syndrome and amyotrophic lateral sclerosis are also associated with chromosome 21. Translocations are found to occur between chromosome 21 and 8, and chromosome 21 and 12, in certain leukemias. The C21orf58 gene product has been provisionally designated C21orf58 pending further characterization.
Catalog Number:
(76120-336)
Supplier:
Bioss
Description:
The smallest of the human chromosomes, 21 makes up about 1.5% of the human genome. Chromosome 21 contains nearly 300 genes and 47 million base pairs. Down syndrome, also known as trisomy 21, is the disease most commonly associated with chromosome 21. Alzheimer's disease, Jervell and Lange-Nielsen syndrome and amyotrophic lateral sclerosis are also associated with chromosome 21. Translocations are found to occur between chromosome 21 and 8, and chromosome 21 and 12, in certain leukemias. The C21orf62 gene product has been provisionally designated C21orf62 pending further characterization.
Supplier:
Bel-Art Products
Description:
Ideal for sampling from narrow- or wide-mouth containers up to 208-liter (55 Gallon) drums.
Supplier:
Corning
Description:
The Falcon® HTS 24-multiwell insert system is designed to automate many commonly used membrane-based cell assays and increase the productivity and throughput of these assays in the drug discovery process. Available in a choice of membrane pore sizes (1, 3 and 8 µm), 24-multiwell inserts have been successfully used for a variety of applications including permeability studies for oral bioavailability and absorption studies (Caco-2 cells), chemotaxis, cell migration and invasion assays.
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