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electrophoresis+reagents+HyClone+products+(Cytiva)
Catalog Number:
(10107-308)
Supplier:
Prosci
Description:
SMAD1 belongs to the SMAD family. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. SMAD1 mediates the signals of the bone morphogenetic proteins (BMPs), which are involved in a range of biological activities including cell growth, apoptosis, morphogenesis, development and immune responses. In response to BMP ligands, SMAD1 can be phosphorylated and activated by the BMP receptor kinase. The phosphorylated form of SMAD1 forms a complex with SMAD4, which is important for its function in the transcription regulation. SMAD1 is a target for SMAD-specific E3 ubiquitin ligases, such as SMURF1 and SMURF2, and undergoes ubiquitination and proteasome-mediated degradation.The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signals of the bone morphogenetic proteins (BMPs), which are involved in a range of biological activities including cell growth, apoptosis, morphogenesis, development and immune responses. In response to BMP ligands, this protein can be phosphorylated and activated by the BMP receptor kinase. The phosphorylated form of this protein forms a complex with SMAD4, which is important for its function in the transcription regulation. This protein is a target for SMAD-specific E3 ubiquitin ligases, such as SMURF1 and SMURF2, and undergoes ubiquitination and proteasome-mediated degradation. Alternatively spliced transcript variants encoding the same protein have been observed.
Catalog Number:
(CAPIPA5-18335)
Supplier:
Thermo Scientific
Description:
Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-transferase that belongs to the mu class. The mu class of enzymes functions in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding the mu class of enzymes are organized in a gene cluster on chromosome 1p13. 3 and are known to be highly polymorphic. These genetic variations can change an individual's susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of certain drugs. Null mutations of this class mu gene have been linked with an increase in a number of cancers, likely due to an increased susceptibility to environmental toxins and carcinogens. Multiple protein isoforms are encoded by transcript variants of this gene.
Catalog Number:
(CAPIPA5-14807)
Supplier:
Thermo Scientific
Description:
Protein kinases are enzymes that transfer a phosphate group from a phosphate donor, generally the g phosphate of ATP, onto an acceptor amino acid in a substrate protein. By this basic mechanism, protein kinases mediate most of the signal transduction in eukaryotic cells, regulating cellular metabolism, transcription, cell cycle progression, cytoskeletal rearrangement and cell movement, apoptosis, and differentiation. With more than 500 gene products, the protein kinase family is one of the largest families of proteins in eukaryotes. The family has been classified in 8 major groups based on sequence comparison of their tyrosine (PTK) or serine/threonine (STK) kinase catalytic domains. The tyrosine kinase (TK) group is mainly involved in the regulation of cell-cell interactions such as differentiation, adhesion, motility and death. There are currently about 90 TK genes sequenced, 58 are of receptor protein TK (e.g. EGFR, EPH, FGFR, PDGFR, TRK, and VEGFR families), and 32 of cytosolic TK (e.g. ABL, FAK, JAK, and SRC families).
Catalog Number:
(CAPI22309)
Supplier:
LIFE TECHNOLOGIES CORP CA
Description:
Thermo Scientific Pierce GMBS is an amine-to-sulfhydryl crosslinker that contains NHS-ester and maleimide reactive groups at opposite ends of a short spacer arm (7.3 angstroms).
Catalog Number:
(CASX0795-1)
Supplier:
MilliporeSigma
Description:
Meets ACS Specifications, Meets Reagent Specifications for testing USP/NF monographs
Catalog Number:
(MSPP-780821006)
Supplier:
Stemcell Technologies
Description:
Interleukin 21 (IL-21) is a pleiotropic cytokine that is composed of four α-helical bundles and primarily produced by natural killer T (NKT) cells, T follicular helper (Tfh) cells, and Th17 cells (Spolski and Leonard 2008). IL-21 signals via heterodimers of the IL-21 receptor (IL-21R) and the IL2RG encoded common cytokine receptor γ-chain (Parrish-Novak <i>et al.</i>; Ozaki K <i>et al.</i> 2000), and utilizes the JAK/STAT, MAPK, and PI3K pathways (Spolski and Leonard 2014). IL-21 has been shown to have a critical role in regulating immunoglobulin production and differentiation of the pro-inflammatory Th17 population of cells (Ozaki <i>et al.</i> 2002; Nurieva <i>et al.</i>). Additionally, IL-21 specifically sustains CD8+ T cell effector activity and provides a mechanism of CD4+ T cell help during chronic viral infection (Elsaesser <i>et al.</i>). IL-21 signaling was also found critical for the development of type 1 diabetes in NOD mice (Sutherland <i>et al.</i>) and control of T cell autoimmunity by regulatory B cells (Yoshizaki <i>et al.</i>).
Supplier:
GE Healthcare - Life Sciences
Description:
Polycap HD (Heavy Duty) capsule filter offers a broad range of particle size retention ratings and excellent filtrate purity with polypropylene filters (PP).
Supplier:
Foodchek
Description:
Food and environmental samples require enrichment before pathogen testing, enabling any bacterial pathogen present to grow and be detected in test samples
Catalog Number:
(CAPI22297)
Supplier:
LIFE TECHNOLOGIES CORP CA
Description:
Thermo Scientific Pierce BMPH is a short, maleimide-and-hydrazide crosslinker for conjugating sulfhydryls (cysteines) to carbonyls (aldehyde or ketones, such as those formed by oxidation of glycoprotein carbohydrates).
Supplier:
Thermo Scientific Chemicals
Description:
Applications: Stabilizer for HCN, temperature indicator
Soluble in aqueous ammonia. Insoluble in water. Slightly soluble in acids
Supplier:
Sartorius
Description:
Arium comfort systems produce ASTM Type 1 ultrapure water and Type 3 pure water.
Catalog Number:
(CA200-343-200)
Supplier:
Rockland Immunochemical
Description:
Primary Mouse Anti-Glutathione-S-Transferase (GST) Reacts with Pan
Catalog Number:
(RK31012)
Supplier:
Restek
Description:
Contains: Aldrin (309-00-2); α-BHC (319-84-6); β-BHC (319-85-7); δ-BHC (319-86-8); γ-BHC (Lindane) (58-89-9); 4,4'-DDD (72-54-8); 4,4'-DDE (72-55-9); 4,4'-DDT (50-29-3); Dieldrin (60-57-1); Endosulfan I (959-98-8); Endosulfan II (33213-65-9); Endosulfan sulfate (1031-07-8); Endrin (72-20-8); Endrin aldehyde (7421-93-4); Endrin ketone (53494-70-5); Heptachlor (76-44-8); Heptachlor epoxide (isomer B) (1024-57-3); Methoxychlor (72-43-5)
Catalog Number:
(CA600-401-483)
Supplier:
Rockland Immunochemical
Description:
This affinity purified antibody has been tested for use in ELISA and western blotting.
Supplier:
BioFit
Description:
Used to transport resources between classrooms or as a standalone multipurpose activity center, the BioFit STEAM Cart is a versatile mobile learning platform specially designed to help educate tomorrow’s innovators; its rugged, kid-friendly construction and flexibility make it a popular solution in today’s most progressive K-12 learning environments and maker spaces alike.
Catalog Number:
(CAPIPA5-15552)
Supplier:
Thermo Scientific
Description:
This antibody is predicted to react with bovine based on sequence homology. DUSP6 is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP)kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associatedwith cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK2, is expressed in a variety of tissues with the highest levels in heart and pancreas, and unlike most other members of this family, is localized in the cytoplasm. Twotranscript variants encoding different isoforms have been found for the DUSP6 gene.
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