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electrophoresis+reagents+HyClone+products+(Cytiva)
Catalog Number:
(470019-372)
Supplier:
Brinsea Products
Description:
Handheld and easy to use.
Supplier:
AVANTOR PERFORMANCE MATERIAL LLC
Description:
Fine crystals. Lot analysis on label.
Supplier:
Colder Products
Description:
Ensure a sterile connection.
Supplier:
OSAW INDUSTRIAL PRODUCTS SE
Description:
High quality and low cost make this ideally suited for junior high or high school students.
Supplier:
Bel-Art Products
Description:
EnviroKleen™ certified thermometers feature black, non-toxic, biodegradable, Enviro-Safe® liquid against lead-free, yellow back glass for easy readability and fewer reading errors.
Supplier:
Enzo Life Sciences
Description:
The proteasome is widely recognised as the central enzyme of non-lysosomal protein degradation. It is responsible for intracellular protein turnover and it is also critically involved in many regulatory processes and, in higher eukaryotes, in antigen processing. An enzymatic cascade is responsible for the attachment of multiple ubiquitin molecules to lysine residues of proteins targeted for degradation. The 26S proteasome is the key enzyme of the ubiquitin/ATP-dependent pathway of protein degradation.
The catalytic core of this unusually large (2000kDa, 450Å in length) complex (31 subunits) is formed by the 20S proteasome, a barrel shaped structure shown by electron microscopy to comprise of four rings each containing seven subunits. 20S Proteasomes degrade only unfolded proteins in an energy-independent manner, whereas 26S proteasomes degrade native and ubiquitinylated proteins in an ATP-dependent manner. The native protein substrates are recognised by subunits, some with ATP binding sites, of the outer 19S caps of the 26S proteasome. The 19S regulatory subunit recognizes ubiquitinated proteins and plays an essential role in unfolding and translocating targets into the lumen of the 20S subunit. A second activator which can associate with the 20S proteasome in the absence of ATP is known as PA28 or the 11S regulator. The pure PA28 activator is a complex of two alternating subunits, PA28α and PA28β, which share approximately 50% homology but also show considerable similarity (30-40%) to a nuclear protein of unknown function, the Ki autoantigen (recently referred to as PA28γ). These subunits, with an apparent relative molecular weight of approximately 29kDa, form ringlike heteromeric complexes of ~200kDa possibly with an α3β3 stoichiometry. Electron microscopic studies have shown PA28 to be a ring shaped particle which, like the 19S, caps the 20S proteasome, by binding to the α-rings, at both or either end. The complex may, however, be readily dissociated. The finding that PA28 modulates the proteasome-catalysed production of antigenic peptides presented to the immune system on MHC class I molecules indicates a cellular function of this activator in antigen processing. Several genetic diseases are associated with defects in the ubiquitin-proteasome pathway. Some examples of affected proteins include those linked to cystic fibrosis, Angelman's syndrome, and Liddle syndrome.
Catalog Number:
(MFLX06360-18BLK)
Supplier:
Colder Products
Description:
Fittings connect in a snap.
Catalog Number:
(76212-310)
Supplier:
Zymo Research
Description:
The Zymoprep™ Yeast Plasmid Miniprep II used for plasmid isolation from <i>S. pombe.</i>
Catalog Number:
(470178-226)
Supplier:
ALTHOR PRODUCTS LLC
Description:
This clear plastic box has a telescoping cover that fits snugly and lifts off completely.
Catalog Number:
(CA21290-00)
Supplier:
Hach
Description:
Simple, low-cost color disc method is the most accurate visual test kit method.
Supplier:
Spectrum Chemicals
Description:
DL-Menthol, Crystal, FCC is used as a flavor and fragrance additive. The FCC grade meets the requirements of the Food Chemical Codex indicates and is suitable for all food, beverage and nutritional supplement applications. Spectrum Chemical offers over 300 Food grade chemical ingredients packaged in laboratory size bottles to production drum quantities and are manufactured, packaged and stored under current Good Manufacturing Practices (cGMP) per 21CFR part 211 in FDA registered and inspected facilities.
Catalog Number:
(470029-810)
Supplier:
EDUCATIONAL & SCIEN. PRODUCT
Description:
Explore The Interior Of Blood Vessels On Raised-Relief Plaque
Catalog Number:
(470029-794)
Supplier:
EDUCATIONAL & SCIEN. PRODUCT
Description:
View Circulation And Neural Anatomy In Life-Size Human Skull
Catalog Number:
(62866-107)
Supplier:
Bel-Art Products
Description:
Make precise additions of liquid components to microplate wells by adjusting plates to the most convenient angle.
Supplier:
MICROMOLD PRODUCTS, INC.
Description:
Maintain a permanent connection.
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