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electrophoresis+reagents+HyClone+products+(Cytiva)
Supplier:
Nichiryo America
Description:
Lightweight, brightly colored digital models are designed for the precise and accurate pipetting of solutions and reagents, as well as other liquid handling applications.
Catalog Number:
(76509-894)
Supplier:
Genscript
Description:
The product is specific for Tocilizumab. This antibody serves as an excellent positive control for Tocilizumab immunogenicity (ADA) assays.
Catalog Number:
(10666-770)
Supplier:
Bioss
Description:
Required for the innate immune response. Downstream effector of the Toll-like receptor (TLR), TNF and IL-1 beta signaling pathways leading to the production of IL-6. Forms a complex with YWHAB that acts to repress transcription of DUSP1.
Catalog Number:
(CA710-1607)
Supplier:
Rockland Immunochemical
Description:
This product is designed for immunofluorescence microscopy, fluorescence based plate assays (FLISA) and fluorescent western blotting. This product is also suitable for multiplex analysis, including multicolor imaging, utilizing various commercial platforms.
Catalog Number:
(10103-910)
Supplier:
Prosci
Description:
HAX1 is known to associate with hematopoietic cell-specific Lyn substrate 1, a substrate of Src family tyrosine kinases. It also interacts with the product of the polycystic kidney disease 2 gene, mutations in which are associated with autosomal-dominant polycystic kidney disease, and with the F-actin-binding protein, cortactin. It was earlier thought that this gene product is mainly localized in the mitochondria, however, recent studies indicate it to be localized in the cell body. Mutations in this gene result in autosomal recessive severe congenital neutropenia, also known as Kostmann disease.The protein encoded by this gene is known to associate with hematopoietic cell-specific Lyn substrate 1, a substrate of Src family tyrosine kinases. It also interacts with the product of the polycystic kidney disease 2 gene, mutations in which are associated with autosomal-dominant polycystic kidney disease, and with the F-actin-binding protein, cortactin. It was earlier thought that this gene product is mainly localized in the mitochondria, however, recent studies indicate it to be localized in the cell body. Mutations in this gene result in autosomal recessive severe congenital neutropenia, also known as Kostmann disease. Two transcript variants encoding different isoforms have been found for this gene.
Catalog Number:
(10798-452)
Supplier:
Prosci
Description:
Tumor necrosis factor alpha (TNF?) is a cytokine produced primarily by monocytes and macrophages. It is found in synovial cells and macrophages in the tissues.The primary role of TNF? is in the regulation of immune cells. TNF? is able to induce apoptotic cell death, to induce inflammation, and to inhibit tumorigenesis and viral replication. Dysregulation of TNF? production has been implicated in a variety of human diseases, including major depression, Alzheimer's disease and cancer. Recombinant TNF? is used as an immunostimulant under the INN tasonermin. TNF? can be produced ectopically in the setting of malignancy and parallels parathyroid hormone both in causing secondary hypercalcemia and in the cancers with which excessive production is associated.
Supplier:
Ansell Healthcare
Description:
First ergonomically certified chemical glove. Maximize worker productivity by minimizing hand fatigue.
Catalog Number:
(10369-422)
Supplier:
Bioss
Description:
Required for lipopolysaccharide (LPS)-induced, TLR4-mediated activation of the MAPK/ERK pathway in macrophages, thus being critical for production of the proinflammatory cytokine TNF-alpha (TNF) during immune responses. Involved in the regulation of T-helper cell differentiation and IFNG expression in T-cells. Involved in mediating host resistance to bacterial infection through negative regulation of type I interferon (IFN) production. In vitro, activates MAPK/ERK pathway in response to IL1 in an IRAK1-independent manner, leading to up-regulation of IL8 and CCL4. Transduces CD40 and TNFRSF1A signals that activate ERK in B-cells and macrophages, and thus may play a role in the regulation of immunoglobulin production. May also play a role in the transduction of TNF signals that activate JNK and NF-kappa-B in some cell types. In adipocytes, activates MAPK/ERK pathway in an IKBKB-dependent manner in response to IL1B and TNF, but not insulin, leading to induction of lipolysis. Plays a role in the cell cycle. Isoform 1 shows some transforming activity, although it is much weaker than that of the activated oncogenic variant.
Catalog Number:
(75791-478)
Supplier:
Prosci
Description:
LY86 is a protein that in humans is encoded by the LY86 gene, which May cooperate with CD180 and TLR4 to mediate the innate immune response to bacterial lipopolysaccharide (LPS) and cytokine production. Important for efficient CD180 cell surface expression.
Catalog Number:
(76338-186)
Supplier:
Marlin Steel Wire Products
Description:
Powder coated steel rack with 6 quart capacity.
Catalog Number:
(10375-520)
Supplier:
Bioss
Description:
Required for lipopolysaccharide (LPS)-induced, TLR4-mediated activation of the MAPK/ERK pathway in macrophages, thus being critical for production of the proinflammatory cytokine TNF-alpha (TNF) during immune responses. Involved in the regulation of T-helper cell differentiation and IFNG expression in T-cells. Involved in mediating host resistance to bacterial infection through negative regulation of type I interferon (IFN) production. In vitro, activates MAPK/ERK pathway in response to IL1 in an IRAK1-independent manner, leading to up-regulation of IL8 and CCL4. Transduces CD40 and TNFRSF1A signals that activate ERK in B-cells and macrophages, and thus may play a role in the regulation of immunoglobulin production. May also play a role in the transduction of TNF signals that activate JNK and NF-kappa-B in some cell types. In adipocytes, activates MAPK/ERK pathway in an IKBKB-dependent manner in response to IL1B and TNF, but not insulin, leading to induction of lipolysis. Plays a role in the cell cycle. Isoform 1 shows some transforming activity, although it is much weaker than that of the activated oncogenic variant.
Supplier:
Diagnostic Biosystems
Description:
The BCL-2 product is considered to act as an inhibitor of apoptosis. BCL-2 expression is inhibited in germinal centers where apoptosis forms part of the B cell production pathway. Reactive follicles show no staining for BCL-2, whereas the cells in neoplastic follicles exhibit membrane staining. BCL-2 α oncoprotein has been shown to inhibit apoptosis.
Catalog Number:
(10464-026)
Supplier:
Bioss
Description:
CTRP1 enhances the production of aldosterone. CTRP1 was highly expressed in obese subjects as well as up-regulated in hypertensive patients, CTRP1 may be a newly identified molecular link between obesity and hypertension.
Catalog Number:
(10469-986)
Supplier:
Bioss
Description:
The product of the GAJ gene associates with HOP2 to form a stable heterodimeric complex that binds DNA and stimulates the recombinase activity of RAD51 and DMC1. Both the MND1 and HOP2 genes are indispensable for meiotic recombination.
Supplier:
Remco Products
Description:
The hygienic design minimizes the risk of cross-contamination and makes it easy to clean and maintain.
Supplier:
Micronova
Description:
These durably constructed squeegees are made with a polypropylene frame and a choice of either solid rubber or double foam blades for use in wash and production areas. Designed with an ACME threaded handle connection for use with most threaded plastic handles.
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