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electrophoresis+reagents+HyClone+products+(Cytiva)
Catalog Number:
(10109-296)
Supplier:
Prosci
Description:
SHH is a protein that is instrumental in patterning the early embryo. It has been implicated as the key inductive signal in patterning of the ventral neural tube, the anterior-posterior limb axis, and the ventral somites. Defects in this protein or in its signalling pathway are a cause of holoprosencephaly (HPE). It is also thought that mutations in its gene or in its signalling pathway may be responsible for VACTERL syndrome, which is characterized by vertebral defects, anal atresia, tracheoesophageal fistula with esophageal atresia, radial and renal dysplasia, cardiac anomalies, and limb abnormalities.This gene, which is expressed only during embryogenesis, encodes a protein that is instrumental in patterning the early embryo. It has been implicated as the key inductive signal in patterning of the ventral neural tube, the anterior-posterior limb axis, and the ventral somites. Of three human proteins showing sequence and functional similarity to the sonic hedgehog protein of Drosophila, this protein is the most similar. The protein is made as a precursor that is autocatalytically cleaved; the N-terminal portion is soluble and contains the signalling activity while the C-terminal portion is involved in precursor processing. More importantly, the C-terminal product covalently attaches a cholesterol moiety to the N-terminal product, restricting the N-terminal product to the cell surface and preventing it from freely diffusing throughout the developing embryo. Defects in this protein or in its signalling pathway are a cause of holoprosencephaly (HPE), a disorder in which the developing forebrain fails to correctly separate into right and left hemispheres. HPE is manifested by facial deformities. In addition, it is thought that mutations in this gene or in its signalling pathway may be responsible for VACTERL syndrome, which is characterized by vertebral defects, anal atresia, tracheoesophageal fistula with esophageal atresia, radial and renal dysplasia, cardiac anomalies, and limb abnormalities.
Catalog Number:
(89415-988)
Supplier:
Prosci
Description:
TOLLIP Antibody: Toll-like receptors (TLRs) are evolutionarily conserved pattern-recognition molecules resembling the toll proteins that mediate antimicrobial responses in Drosophila. These proteins recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses. The TLRs act through adaptor molecules to activate various kinases and transcription factors so the organism can respond to potential infection. These adaptor molecules include TOLLIP, MyD88, and TRIF. TOLLIP associates directly with TLR2 and TLR 4, acting as an inhibitor to TLR activation. This negative regulation of TLR signaling may serve to limit the production of proinflammatory mediators during infection and inflammation.
Catalog Number:
(CA82022-600)
Supplier:
G-Biosciences
Description:
For the enrichment of cytoplasmic and nuclear fractions from cultured cells and tissues
Supplier:
DWK Life Sciences (KIMBLE)
Description:
High-quality LC injection valve accessories for use with LC applications.
Catalog Number:
(76085-510)
Supplier:
Bioss
Description:
Galactokinase is a major enzyme for the metabolism of galactose and its deficiency causes congenital cataracts in the adult population. GALK1 sequence shares the greatest level of conservation, 44.5% identity with that from E. coli and 34.6% amino acid identity with the product of the human GALK2 gene.
Catalog Number:
(76474-658)
Supplier:
Transforming Technologies
Description:
Anti-Static and ESD curtains are a great way to separate critical workspaces while also attending to the static-sensitive nature of certain products.
Catalog Number:
(10100-642)
Supplier:
Prosci
Description:
HTR2A belongs to the G-protein coupled receptor 1 family. It is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. This receptor is involved in tracheal smooth muscle contraction, bronchoconstriction, and control of aldosterone production.
Catalog Number:
(77282-338)
Supplier:
Brady Worldwide
Description:
Amazing on their own, even better together. Add the power of on-demand printing to lockout tagout, confined space and maintenance safety software for the ultimate in procedure management and facility ID. Get convenience and productivity with the LINK360® safety software with BradyPrinter S3100 sign and label printer and lockout materials kit.
Catalog Number:
(10068-902)
Supplier:
Prosci
Description:
The production of the second messenger molecules diacylglycerol. (DAG) and inositol 1, 4, 5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. It is a crucial enzyme in transmembrane signaling.
Catalog Number:
(10073-054)
Supplier:
Prosci
Description:
The three mammalian isoforms of TGF-β, TGF-β1, β2, β3, signal through the same receptor and elicit similar biological responses. They are multifunctional cytokines that regulate cell proliferation, growth, differentiation and motility as well as synthesis and deposition of the extracellular matrix. They are involved in various physiological processes including embryogenesis, tissue remodeling and would healing. They are secreted predominantly as latent complexes which are stored at the cell surface and in the extracellular matrix. The release of biologically active TGF-β isoform from a latent complex involves proteolytic processing of the complex and /or induction of conformational changes by proteins such as thrombospondin-1. The physiological role of TGF-β3 is still unknown but its expression pattern suggests a role in the regulation of certain development processes. Recombinant TGF-β3 is a 25.0 kDa protein composed of two identical 112 amino acid polypeptide chains linked by a single disulfide bond.Manufactured using all non-animal reagents.
Supplier:
BioFit
Description:
Eton Series chairs boast a number of ergonomic features and benefits that make them a popular choice for laboratory, healthcare, education and technical workspaces. The ergonomic design enhances user comfort and productivity when sitting for prolonged periods.
Catalog Number:
(76423-144)
Supplier:
BioFit
Description:
Elite Series chairs boast a number of ergonomic features and benefits that make them a popular choice for laboratory, healthcare, education and technical workspaces. The ergonomic design enhances user comfort and productivity when sitting for prolonged periods.
Supplier:
Thermo Scientific
Description:
Enjoy strict quality control of raw materials and finished product and a high quality product every time with the Epredia™ Eosin-Y Alcoholic, Eosin-Y with Phloxine, and Eosin-Y Saturated Staining Solutions.
Supplier:
Thermo Scientific Chemicals
Description:
PDPPTT, Formula: (C68H104N2O2S4)n Weight %: <=100 Synonyms: Poly[2,5-(2-decyltetradecyl)-3,6-diketopyrrolopyrrole-alt-5,5-(2,5- di(thien-2- yl)thieno[3,2-b]thiophene)] Storage nd Sensitivity: Ambient temperatures, Size: 100mg
Catalog Number:
(RL600-144-096)
Supplier:
Rockland Immunochemical
Description:
Anti-Fluorescein Antibody Dylight® 680 Conjugated is designed for immunofluorescence microscopy, fluorescence based plate assays (FLISA) and fluorescent western blotting. This product is also suitable for multiplex analysis, including multicolor imaging.
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