Supplier >
BIOTIUM, INC
Print…
You Searched For:
9,422 results were found
BIOTIUM, INC
Supplier:
Biotium
Description:
This antibody recognizes a protein of ~55 kDa, identified as SOX10. This MAb is highly specific and does not cross-react with other members of the SOX-family. SOX genes comprise a family of genes that are related to the mammalian sex-determining gene SRY. These genes similarly contain sequences that encode for the HMG-box domain, which is responsible for the sequence-specific DNA-binding activity. SOX-10 is a sensitive marker of melanoma, including conventional, spindled, and desmoplastic subtypes. It is expressed by metastatic melanomas and nodal capsular nevus in sentinel lymph nodes, but not by other lymph node components such as dendritic cells, which usually express S100 protein. Commonly used melanoma markers, such as anti-HMB-45 and anti-Melan-A, are poorly expressed in desmoplastic melanomas while SOX-10 is moderately to strongly expressed in desmoplastic melanomas. SOX-10 is considered as a very reliable marker for recognizing residual desmoplastic melanomas. In normal tissues, it is expressed in Schwann cells, melanocytes, and myoepithelial cells of salivary, bronchial and mammary glands. SOX-10 expression is also observed in mast cells.
CF® dyes are Biotium's next-generation fluorescent dyes. CF®488A is a green fluorescent dye (Ex/Em 490/515 nm) with excellent brightness and photostability. The dye is minimally charged for less non-specific binding. CF®488A also is compatible with super-resolution imaging by TIRF.
Supplier:
Biotium
Description:
Thyroglobulin, Monoclonal antibody, Clone: TGB04 + TGB05, Host: Mouse, Species reactivity: Mouse, Rat, Human, Isotype: IgG1, kappa, Conjugate: CF405S, Immunogen: Human thyroid follicular cells, Synonyms: AITD3, hTG, TDH3, Tg, Tgn, Size: 500uL
Supplier:
Biotium
Description:
TAG-72 / CA72.4, Monoclonal antibody, Clone: CA72/145, Host: Mouse, Species reactivity: Human, Hamster, Dog, Cow, Rat, Isotype: IgG1, kappa, Conjugate: biotin, Immunogen: Membrane-enriched fraction of a human breast, Synonym: CA72.4, Size: 500uL
Catalog Number:
(75974-740)
Supplier:
Biotium
Description:
TAG-72 / CA72.4, Monoclonal antibody, Clone: B72.3 + CC49, Host: Mouse, Species reactivity: Human, Hamster, Dog, Cow, Rat, Isotype: IgG1, kappa, BSA-free, Immunogen: Membrane-enriched fraction of a human breast, Synonym: CA72.4, Size: 50 uL
Supplier:
Biotium
Description:
This antibody reacts with the TGF alpha and shows no cross-reaction with EGF and the neuropeptide synenkephalin. The staining with this MAb is completely blocked by the peptide used for raising this antibody. TGF alpha (aa50) is a growth factor with 33% homology to EGF, binds to EGFR, activates tyrosine phosphorylation of the receptor, and stimulates cell proliferation. It plays a role in tumor initiation by inducing the reversible transformed phenotype.
Supplier:
Biotium
Description:
TGF-alpha, Monoclonal antibody, Clone: MF9, Host: Mouse, Species reactivity: Rabbit, Zebrafish, Human, Isotype: IgG1, kappa, Conjugate: CF488A, Immunogen: A 10-amino acid synthetic peptide (aa34-43), Synonyms: EGF-like TGF; ETGF, Application: IF, Size: 500uL
Catalog Number:
(75975-412)
Supplier:
Biotium
Description:
TGF-alpha, Monoclonal antibody, Clone: MF9, Host: Mouse, Species reactivity: Rabbit, Zebrafish, Human, Isotype: IgG1, kappa, BSA-free, Immunogen: A 10-amino acid synthetic peptide (aa34-43), Synonyms: EGF-like TGF; ETGF, Application: IF, Size: 50 uL
Supplier:
Biotium
Description:
SUMO-2, Monoclonal antibody, Clone: SUMO2/1199, Host: Mouse, Species reactivity: Human, Rat, Isotype: IgG1, Conjugate: CF647, Immunogen: Recombinant human SUMO2 protein, Application: Immunofluorescence, Immunohistology (formalin), Flow cytometry, Size: 500uL
Supplier:
Biotium
Description:
Thyroglobulin, Monoclonal antibody, Clone: 2H11, Host: Mouse, Species reactivity: Mouse, Rat, Human, Isotype: IgG1, kappa, Conjugate: CF488A, Immunogen: Human thyroid follicular cells, Synonyms: AITD3, Application: Immunohistology (formalin), Flow cytometry, Size: 100uL
Supplier:
Biotium
Description:
TAG-72 / CA72.4, Monoclonal antibody, Clone: B72.3 + CA72/733, Host: Mouse, Species reactivity: Human, Hamster, Dog, Cow, Rat, Isotype: IgG1, kappa, Conjugate: CF488A, Immunogen: Membrane-enriched fraction of a human breast, Synonym: CA72.4, Size: 500uL
Supplier:
Biotium
Description:
TGF-alpha, Monoclonal antibody, Clone: MF9, Host: Mouse, Species reactivity: Rabbit, Zebrafish, Human, Isotype: IgG1, kappa, Conjugate: purified, Immunogen: A 10-amino acid synthetic peptide (aa34-43), Synonyms: EGF-like TGF; ETGF, Application: IF, Size: 100uL
Supplier:
Biotium
Description:
This antibody reacts with the TGF alpha and shows no cross-reaction with EGF and the neuropeptide synenkephalin. The staining with this MAb is completely blocked by the peptide used for raising this antibody. TGF alpha (aa50) is a growth factor with 33% homology to EGF, binds to EGFR, activates tyrosine phosphorylation of the receptor, and stimulates cell proliferation. It plays a role in tumor initiation by inducing the reversible transformed phenotype.
Supplier:
Biotium
Description:
TGF-alpha, Monoclonal antibody, Clone: TGFA/1119, Host: Mouse, Species reactivity: Rabbit, Zebrafish, Human, Isotype: IgG1, kappa, Conjugate: purified, Immunogen: A 10-amino acid synthetic peptide (aa34-43), Synonyms: EGF-like TGF; ETGF, Application: IF, Size: 100uL
Supplier:
Biotium
Description:
DNA topoisomerases are nuclear enzymes that regulate the topological structure of DNA in eukaryotic cells by transiently breaking and rejoining DNA strands. Due to their roles in DNA replication, recombination, and transcription, DNA topoisomerases have been identified as targets of numerous anticancer drugs. Mitochondrial Topo I (DNA topoisomerase I, mitochondrial) is a 601 amino acid protein that primarily acts to relieve DNA strain that may occur during duplication of mitochondrial DNA. As a type IB topoisomerase, mitochondrial Topo I requires a divalent metal, either, calcium or magnesium, as well as an alkaline pH for optimal activity.
CF® dyes are Biotium's next-generation fluorescent dyes. CF®647 is a far-red fluorescent dye (Ex/Em 650/665 nm) with excellent brightness. It also is compatible with super-resolution imaging by STORM.
Supplier:
Biotium
Description:
This antibody neutralizes TNF alpha biological activities. It prevents TNF alpha induced apoptosis in Jurkat cells. It also neutralizes HurTNFamediated cytotoxicity of L929 cells and inhibits tumor growth in mice. It protects mice against toxicity of HurTNFa. Tumor Necrosis Factor Alpha (TNF alpha) is a protein secreted by lipopolysaccharide-stimulated macrophages, and causes tumor necrosis when injected into tumor bearing mice. TNF alpha is believed to mediate pathogenic shock and tissue injury associated with endotoxemia. TNF alpha exists as a multimer of two, three, or five non-covalently linked units, but shows a single 17 kDa band following SDS PAGE under non-reducing conditions. TNF alpha is closely related to the 25 kDa protein Tumor Necrosis Factor beta (lymphotoxin), sharing the same receptors and cellular actions. TNF alpha causes cytolysis of certain transformed cells, being synergistic with interferon gamma in its cytotoxicity. Although it has little effect on many cultured normal human cells, TNF alpha appears to be directly toxic to vascular endothelial cells. Other actions of TNF alpha include stimulating growth of human fibroblasts and other cell lines, activating polymorphonuclear neutrophils and osteoclasts, and induction of interleukin 1, prostaglandin E2 and collagenase production.
CF® dyes are Biotium's next-generation fluorescent dyes. CF®594 is a deep red fluorescent dye (Ex/Em 593/614 nm). It yields the brightest conjugates among spectrally similar dyes, and has excellent photostability.
Supplier:
Biotium
Description:
This antibody neutralises HurTNFamediated cytotoxicity of L929 cells and inhibits tumour growth in mice. It protects mice against toxicity of HurTNFa. Tumor Necrosis Factor Alpha (TNF alpha) is a protein secreted by lipopolysaccharide-stimulated macrophages, and causes tumor necrosis when injected into tumor bearing mice. TNF alpha is believed to mediate pathogenic shock and tissue injury associated with endotoxemia. TNF alpha exists as a multimer of two, three, or five non-covalently linked units, but shows a single 17 kDa band following SDS PAGE under non-reducing conditions. TNF alpha is closely related to the 25 kDa protein Tumor Necrosis Factor beta (lymphotoxin), sharing the same receptors and cellular actions. TNF alpha causes cytolysis of certain transformed cells, being synergistic with interferon gamma in its cytotoxicity. Although it has little effect on many cultured normal human cells, TNF alpha appears to be directly toxic to vascular endothelial cells. Other actions of TNF alpha include stimulating growth of human fibroblasts and other cell lines, activating polymorphonuclear neutrophils and osteoclasts, and induction of interleukin 1, prostaglandin E2 and collagenase production.
CF® dyes are Biotium's next-generation fluorescent dyes. CF®405S is a blue fluorescent dye (Ex/Em 404/431 nm) with superior brightness compared to other blue dyes; it is also compatible with super-resolution imaging by SIM. Note: Conjugates of blue fluorescent dyes are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.
Inquire for Price
Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the
 is still displayed and you need assistance, please call us at 1-800-932-5000.
Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the
is still displayed and you need assistance, please call us at 1-800-932-5000.
You must log in to order restricted items. We request that you provide the required business documentation to purchase this product for the first time.
To order chemicals, medical devices, or other restricted products please provide identification that includes your business name and shipping address via email CMD_NA@vwr.com or fax 484.881.5997 referencing your VWR account number . Acceptable forms of identification are:
-Additional Documentation May be needed to purchase this item. A VWR representative will contact you if needed.
This product has been blocked by your organization. Please contact your purchasing department for more information.
The original product is no longer available. The replacement shown is available.
This product is currently unavailable but limited stock may be available in our extended warehouse network. Please call 1-800-932-5000 and a VWR Customer Service Representative will help you.
|
|||||||||
List View
