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BIOTIUM, INC
Supplier:
Biotium
Description:
The epitope of this MAb is located between aa343-357. Cytokeratin 8 (CK8) belongs to the type II (or B or basic) subfamily of high molecular weight cytokeratins and exists in combination with cytokeratin 18 (CK18). CK8 is primarily found in the non-squamous epithelia and is present in majority of adenocarcinomas and ductal carcinomas. It is absent in squamous cell carcinomas. Hepatocellular carcinomas are defined by the use of antibodies that recognize only cytokeratin 8 and 18. CK8 exists on several types of normal and neoplastic epithelia, including many ductal and glandular epithelia such as colon, stomach, small intestine, trachea, and esophagus as well as in transitional epithelium. Anti-CK8 does not react with skeletal muscle or nerve cells. Epithelioid sarcoma, chordoma, and adamantinoma show strong positivity corresponding to that of simple epithelia (with antibodies against CK8, CK18 and CK19). Reportedly, anti-CK8 is useful for the differentiation of lobular (ring-like, perinuclear) from ductal (peripheral-predominant) carcinoma of the breast.
CF® dyes are Biotium's next-generation fluorescent dyes. CF®647 is a far-red fluorescent dye (Ex/Em 650/665 nm) with excellent brightness. It also is compatible with super-resolution imaging by STORM.
Supplier:
Biotium
Description:
CD8 Monoclonal antibody, Clone: C8/468 + C8/144B, Host: Mouse, Species reactivity: Human, Isotype: IgG1, K, Conjugate: CF594, Immunogen: A 13 amino acid synthetic peptide, C-term, Synonyms: T8/Leu-2, Application: IF, Size: 500 uL
Supplier:
Biotium
Description:
CD171 / L1CAM Monoclonal antibody, Clone: UJ127, Host: Mouse, Conjugate: CF647, Species reactivity: Human, Immunogen: Recombinant human VCAM1 protein, Isotype: IgG1, kappa, Synonyms: CD106; INCAM-100, Application: IF, IHC, Size: 500 uL
Supplier:
Biotium
Description:
This antibody recognizes a 66 kDa protein, which is identified as Tripartite motif-containing protein 29 (TRIM29). It interacts with the intermediate filament protein vimentin, a substrate for the PKC family of protein kinases, and with hPKCI-1, an inhibitor of the PKCs. TRIM29 protein contains both zinc finger and leucine zipper motifs, suggesting that the it may form homodimers and possibly associate with DNA. High expression of TRIM29 has been reported in gastric cancer and pancreatic cancer, and correlates with enhanced tumor growth and lymph node metastasis. TRIM29 is also able to distinguish lung squamous cell carcinoma from lung adenocarcinoma with ~90% positive accuracy, when used in a panel with TTF-1, p63, CK5/6, and Napsin-A antibodies.
CF® dyes are Biotium's next-generation fluorescent dyes. CF®488A is a green fluorescent dye (Ex/Em 490/515 nm) with excellent brightness and photostability. The dye is minimally charged for less non-specific binding. CF®488A also is compatible with super-resolution imaging by TIRF.
Supplier:
Biotium
Description:
Insulin, Monoclonal antibody, Clone: E2-E3 + 2D11-H5, Host: Mouse, Species reactivity: Mouse, Pig, Cow, Human, Rabbit, Isotype: IgG1, kappa, Conjugate: biotin, Immunogen: Purified pig insulin, conjugated to KLH, Synonyms: IDDM2, ILPR, IRDN, MODY10, Application: IF, Size: 500uL
Catalog Number:
(89139-518)
Supplier:
Biotium
Description:
5-(and-6)-Carboxyrhodamine 110-X (full name: 5-(and-6)-Carboxyrhodamine 110-X, hydrochloride) is similar to 5-(and-6)-carboxyrhodamine 110 (#90000). The X linker molecule is useful to reduce the interaction between the dye and the molecule to be labeled.
Supplier:
Biotium
Description:
TAG-72 / CA72.4, Monoclonal antibody, Clone: CC49, Host: Mouse, Species reactivity: Human, Hamster, Dog, Cow, Rat, Isotype: IgG1, kappa, Conjugate: CF568, Immunogen: Membrane-enriched fraction of breast carcinoma, Synonyms: CA72.4, Size: 500uL
Supplier:
Biotium
Description:
HLA-DRB, Monoclonal antibody, Clone: LN-3 + HLA-DRB/1067, Host: Mouse, Species reactivity: Human, Monkey, Isotype: IgG's, Conjugate: CF594, Immunogen: Activated human peripheral blood mononuclear cells (LN-3 & HLA-DRB/1067), Application: IF, IHC Western, Size: 500uL
Supplier:
Biotium
Description:
This MAb reacts with a wide variety of simple epithelia. It does not react with stratified squamous epithelia. It reacts with epithelial tumors of the gastrointestinal tract, lung, breast, pancreas, ovary, and thyroid. Cytokeratin 18, which belongs to the type A (acidic) subfamily of low molecular weight keratins, exists in combination with cytokeratin 8. It was reported that tissues from gastrointestinal tract are positive for both cytokeratin 8 and 18 but do not contain cytokeratin 14. Tissues from gastrointestinal tract, respiratory tract and urogenital tract, as well as endocrine and exocrine tissues and mesothelial cells are positive for cytokeratin 18.
CF® dyes are Biotium's next-generation fluorescent dyes. CF®647 is a far-red fluorescent dye (Ex/Em 650/665 nm) with excellent brightness. It also is compatible with super-resolution imaging by STORM.
Supplier:
Biotium
Description:
Beta-2 microglobulin Monoclonal antibody, Clone: BBM.1, Host: Mouse, Species: Human, Non-human primates, Isotype: IgG2b, kappa, Conjugate: CF405S, Immunogen: Recognizes a protein of 12kDa, Synonyms: Hdcma22p, Application: IF, Immunohistology, Fc, Size: 100ul
Supplier:
Biotium
Description:
ACTH Monoclonal antibody, Clone: 57, Host: Mouse, Species: Mouse, Rat, Human, Isotype: IgG1, kappa, Conjugate: CF647, Immunogen: 39 amino acid active peptide produced by the anterior pituitary, Synonyms: Adrenocorticotropin, Application: IF, IHC, Fc, Size: 500ul
Supplier:
Biotium
Description:
Twenty human keratins are resolved with two-dimensional gel electrophoresis into acidic (pI 6.0) subfamilies. This antibody recognizes acidic (Type I or LMW) and basic (Type II or HMW) cytokeratins, including 59 kDa (CK4); 58 kDa (CK5); 56 kDa (CK6); 52 kDa (CK8); 56.5 kDa (CK10); 53 kDa (CK13) and 45 kDa (CK18). This is a broad-spectrum antibody, which has been reported to differentiate epithelial tumors from non-epithelial tumors. Many studies have shown the usefulness of keratins as markers in cancer research and tumor diagnosis.
Supplier:
Biotium
Description:
IgM Immunoglobulin, Monoclonal antibody, Clone: IM260 + ICO-30, Host: Mouse, Species reactivity: Human, Isotype: IgG1, kappa, Conjugate: CF647, Immunogen: Heavy chain of human IgM, Synonyms: AGM1; IGHM, Application: IF, IHC (formalin), Flow cytometry, Size: 100uL
Supplier:
Biotium
Description:
CD74 Monoclonal antibody, Clone: CLIP/1133, Host: Mouse, Species reactivity: Human, Isotype: IgG1, kappa, Conjugate: CF594, Immunogen: Recombinant full-length human CD74 protein, Application: IF, Western, FC, Size: 500 uL
Supplier:
Biotium
Description:
PLGF, Monoclonal antibody, Clone: PLGF94, Host: Mouse, Species reactivity: Human, Isotype: IgG1, kappa, Conjugate: CF640R, Immunogen: Recombinant human PLGF protein, Synonyms: PGFL; PIGF; placental growth factor (PGF), Application: ELISA, Size: 100uL
Supplier:
Biotium
Description:
with our near-IR fluorescent dye CF680. CF680 is brighter than other spectrally similar dyes and have by far the best signal-to-noise ratio than antibody conjugates prepared from other spectrally similar dyes.
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 is still displayed and you need assistance, please call us at 1-800-932-5000.
Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the
is still displayed and you need assistance, please call us at 1-800-932-5000.
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