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Mass+Spectrometry
Catalog Number:
(10098-386)
Supplier:
Prosci
Description:
Interleukin 6 (IL-6) is a multifunctional 24 kDa protein originally discovered in the medium of RNA stimulated fibroblastoid cells. It is upregulated by IL1, TNF, PDGF, IFN beta, TNF alpha, NGF, IL17 and downregulated by glucocorticoids IL4, TGF beta. IL-6 appears to be directly involved in the responses that occur after infection and cellular injury, and it may prove to be as important as IL1 and TNF alpha in regulating the acute phase response. IL-6 has also been implicated in regulating adipose mass.
Catalog Number:
(10796-742)
Supplier:
Bachem Americas
Description:
In the presence of as little as 1 mol% pPE-amide, a broad range of aldehydes and nitroolefins react readily with each other. The resulting γ-nitroaldehydes were obtained in excellent yields and stereoselectivities at room temperature.
Supplier:
Leica Microsystems
Description:
We move the laser, not the sample. And we use gravity for collection. LMD systems provides perfectly cut, contamination-free, analysis-ready dissectates.
Catalog Number:
(10084-706)
Supplier:
Proteintech
Description:
CHEK1(Checkpoint kinase-1) is also named as CHK1 and belongs to the protein kinase superfamily. It is implicated in a circuit in which it activates checkpoints, DNA repair and proliferating cell nuclear antigen and FANCD2 monoubiquitinylation. CHEK1 protects vertebrate cells against spontaneous chromosome missegregation and is required to sustain anaphase delay when spindle function is disrupted by taxol. It has 3 isoforms produced by alternative splicing with the molecular mass of 54 kDa, 44 kDa and 50 kDa.
Catalog Number:
(75844-412)
Supplier:
BIOGEMS INTERNATIONAL INC.
Description:
The P1H12 monoclonal antibody reacts with CD146, 118kDA transmembrane glycoprotein that is also called the melanoma cell adhesion molecule (Mel-CAM), MUC18, Endo-CAM, and S-Endo. It is a prominently glycosylated protein with carbohydrates comprising the majority of its mass and it is expressed on melanoma, stromal, endothelial, and bone marrow fibroblasts. The P1H12 antibody cross reacts with human, mouse, canine, rabbit to the exclusion of rat protein.
Catalog Number:
(10103-832)
Supplier:
Prosci
Description:
Cytoplasmic dyneins are large enzyme complexes with a molecular mass of about 1,200 kD. They contain two force-producing heads formed primarily from dynein heavy chains, and stalks linking the heads to a basal domain, which contains a varying number of accessory intermediate chains. The complex is involved in intracellular transport and motility. DYNLL1 is a light chain and exists as part of this complex but also physically interacts with and inhibits the activity of neuronal nitric oxide synthase. Binding of this protein destabilizes the neuronal nitric oxide synthase dimer, a conformation necessary for activity, and it may regulate numerous biologic processes through its effects on nitric oxide synthase activity.Cytoplasmic dyneins are large enzyme complexes with a molecular mass of about 1,200 kD. They contain two force-producing heads formed primarily from dynein heavy chains, and stalks linking the heads to a basal domain, which contains a varying number of accessory intermediate chains. The complex is involved in intracellular transport and motility. The protein described in this record is a light chain and exists as part of this complex but also physically interacts with and inhibits the activity of neuronal nitric oxide synthase. Binding of this protein destabilizes the neuronal nitric oxide synthase dimer, a conformation necessary for activity, and it may regulate numerous biologic processes through its effects on nitric oxide synthase activity. Alternate transcriptional splice variants have been characterized.
Supplier:
PeproTech, Inc.
Description:
Mature Myostatin is obtained by proteolytic processing of a biologically-inactive precursor protein, which contains an N-terminal propeptide of 243 amino acid residues. Myostatin-Propeptide exhibits high binding affinity for myostatin, and has been shown to be a potent inhibitor of myostatin. Over-expression of myostatin-propeptide in mice resulted in large increases (up to 200%) in skeletal muscle mass, similar to those observed in myostatin knockout mice. Recombinant Human Myostatin-Propeptide is a 27.8 kDa protein consisting of 244 amino acid residues.
Supplier:
Enzo Life Sciences
Description:
The 19S regulatory complex consists of a ‘base’ sub-complex, composed of a hetero-hexameric ring of AAA-ATPases that not only function as the gate-opener to the 20S proteasome but also, in conjunction with two other high-molecular-mass non-ATPase subunits (Rpn2/S1 and Rpn1/S2), as a platform for protein unfolding. The ‘lid’ sub-complex of the 19S complex, composed of non-ATPase subunits is involved in the binding and deubiquitinylation of proteasome targeted ubiquitin conjugated proteins and assists in the transport of substrates through the ‘base’ and into the 20S catalytic core.
Catalog Number:
(10861-014)
Supplier:
New Pig
Description:
Permanently solidifies to lock in absorbed liquids so they won't leak or liquify when the absorbents are handled or placed under pressure.
Catalog Number:
(75832-844)
Supplier:
Mettler Toledo
Description:
METTLER TOLEDO’s new XPR microbalances incorporate a range of innovative new technologies to deliver the highest accuracy in their class and help make your micro-weighing tasks simpler, safer and more secure.
Catalog Number:
(10098-382)
Supplier:
Prosci
Description:
Interleukin 6 (IL-6) is a multifunctional 24 kDa protein originally discovered in the medium of RNA stimulated fibroblastoid cells. It is upregulated by IL1, TNF, PDGF, IFN beta, TNF alpha, NGF, IL17 and downregulated by glucocorticoids IL4, TGF beta. IL-6 appears to be directly involved in the responses that occur after infection and cellular injury, and it may prove to be as important as IL1 and TNF alpha in regulating the acute phase response. IL-6 has also been implicated in regulating adipose mass.
Catalog Number:
(CAPI90076)
Supplier:
LIFE TECHNOLOGIES CORP CA
Description:
Anti-TMT™ Antibody resin enables selective enrichment of peptides in complex samples that have been labeled with Tandem Mass Tag™ Reagents.
Supplier:
Bachem Americas
Description:
Highly potent and selective β-MSH-derived melanocortin-4 receptor (MC-4R) agonist with sub-nanomolar potency. The binding affinities for human MC-4R, MC-1R, MC-3R and MC-5R were 0.55 ± 0.06, 16.78 ± 1.53, 56.79 ± 4.66, and < 500 nM, respectively. Daily subcutaneous injection of H-6268 to diet-induced obese rats over a period of 14 days demonstrated an effect on reduction of fat mass.
Catalog Number:
(10084-902)
Supplier:
Proteintech
Description:
The gene of CMIP was isolated from one patient of minimal change nephrotic syndrome. The gene encodes two isoforms: CMIP and truncated CMIP. The predicted CMIP and truncated CMIP proteins contain 739 and 679 amino acids and have calculated molecular masses of 85 and 75 kD, respectively. The two isoforms have different distribution and expression pattern.
Supplier:
PeproTech, Inc.
Description:
Erythropoietin (EPO) is a glycoprotein hormone that is principally known for its role in erythropoiesis, where it is responsible for stimulating proliferation and differentiation of erythroid progenitor cells. The differentiation of CFU-E (Colony Forming Unit-Erythroid) cells into erythrocytes can only be accomplished in the presence of EPO. Physiological levels of EPO in adult mammals are maintained primarily by the kidneys, whereas levels in fetal or neonatal mammals are maintained by the liver. EPO also can exert various non-hematopoietic activities, including vascularization and proliferation of smooth muscle, neural protection during hypoxia, and stimulation of certain B cells. PeproTech’s Human EPO contains 166 amino acid residues and has a calculated molecular weight of approximately 18.4 kDa. As a result of glycosylation, Recombinant Human EPO migrates with an apparent molecular mass of 37.0 kDa by SDS-PAGE gel, under reducing and non-reducing conditions.
Catalog Number:
(75793-156)
Supplier:
Prosci
Description:
Leptin is involved in the signaling pathway that regulates the size of the body fat depot. An increase in the level of leptin may act directly or indirectly on the CNS to inhibit food intake and/or regulate energy expenditure as part of a homeostatic mechanism to maintain constancy of the adipose mass. Defects in the leptin gene may be a cause of autosomal recessive obesity.
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