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BIOTIUM, INC
Supplier:
Biotium
Description:
CD43 Monoclonal antibody, Clone: SPN/839, Host: Mouse, Species reactivity: Human, Isotype: IgG1, kappa, Conjugate: purified, Immunogen: Recom full-length human SPN protein, Synonyms: GALGP, GPL115, Application: IF, IHC, WB, FC, Size: 500 uL
Supplier:
Biotium
Description:
Anti-IgG Donkey Polyclonal Antibody (CF™ 770)
Supplier:
Biotium
Description:
Twenty human keratins are resolved with two-dimensional gel electrophoresis into acidic (pI 6.0) subfamilies. This antibody cocktail recognizes acidic (Type I or LMW) and basic (Type II or HMW) cytokeratins, which 67 kDa (CK1); 64 kDa (CK3); 59 kDa (CK4); 58 kDa (CK5); 56 kDa (CK6); 52 kDa (CK8); 56.5 kDa (CK10); 50 kDa (CK14); 50 kDa (CK15); 48 kDa (CK16); 40 kDa (CK19). Many studies have shown the usefulness of keratins as markers in cancer research and tumor diagnosis. AE-1/AE-3 is a broad spectrum anti pan-cytokeratin antibody cocktail, which differentiates epithelial tumors from non-epithelial tumors e.g. squamous vs. adenocarcinoma of the lung, liver carcinoma, breast cancer, and esophageal cancer. It has been used to characterize the source of various neoplasms and to study the distribution of cytokeratin containing cells in epithelia during normal development and during the development of epithelial neoplasms. This antibody stains cytokeratins present in normal and abnormal human tissues and has shown high sensitivity in the recognition of epithelial cells and carcinomas.
CF® dyes are Biotium's next-generation fluorescent dyes. CF®568 is a red fluorescent dye (Ex/Em 562/583 nm) with superior brightness and photostability. It also is compatible with super-resolution imaging by STORM and TIRF.
Supplier:
Biotium
Description:
Anti-IgG Bovine Polyclonal Antibody (CF™ 568)
Supplier:
Biotium
Description:
This antibody recognizes a protein of 25-26 kDa, identified as the bcl-2 α oncoprotein. It shows no cross-reaction with Bcl-x or Bax protein. Expression of bcl-2 α oncoprotein inhibits the programmed cell death (apoptosis). In most follicular lymphomas, neoplastic germinal centers express high levels of bcl-2 α protein, whereas the normal or hyperplastic germinal centers are negative. Consequently, this antibody is valuable when distinguishing between reactive and neoplastic follicular proliferation in lymph node biopsies. It may also be used in distinguishing between those follicular lymphomas that express bcl-2 protein and the small number in which the neoplastic cells are bcl-2 negative.
CF® dyes are Biotium's next-generation fluorescent dyes. CF®594 is a deep red fluorescent dye (Ex/Em 593/614 nm). It yields the brightest conjugates among spectrally similar dyes, and has excellent photostability.
Supplier:
Biotium
Description:
Smooth muscle myosin heavy chain (SM-MHC) is a cytoplasmic structural protein, which is a major component of the contractile apparatus in smooth muscle cells. Expression of smooth muscle myosin is developmentally regulated, appearing early in smooth muscle development, and is specific for smooth muscle development. Two isoforms of smooth muscle myosin heavy chain have been identified, designated MHC-1 and MHC-2. The antibody may be useful for the study of breast tumors as the presence of an intact layer of myoepithelial cells is an important feature, which may distinguish benign breast lesions and carcinoma in situ from invasive tumors.
CF® dyes are Biotium's next-generation fluorescent dyes. CF®488A is a green fluorescent dye (Ex/Em 490/515 nm) with excellent brightness and photostability. The dye is minimally charged for less non-specific binding. CF®488A also is compatible with super-resolution imaging by TIRF.
Supplier:
Biotium
Description:
This antibody recognizes a protein of 205 kDa-220 kDa, identified as CD45RA. CD45RA is isoforms of the human leukocyte common antigen (CD45). Human CD45 contains three exons which encode peptide segments designated A, B and C, respectively. The differential splicing of the exons generates at least five isoforms, ABC, AB, BC, B and O. This antibody reacts with ABC and BC isoforms. CD45RA is expressed on 40-50% of peripheral CD4 T-cells, 50% of peripheral CD8 T-cells, B-cells, and leukemic B-cell lines. T-cells expressing CD45RA are naive or virgin T-cells. T-cells expressing CD45RO are memory T-cells. CD45RA and CD45RO define complementary, predominantly non-overlapping populations of resting peripheral T-cells. This MAb is useful in study on the subpopulation of CD4 or CD8 T-cells. It can especially be used to differentiate T-cell lymphomas (CD45RO ve) from B cell lymphomas (CD45RA ve).
CF® dyes are Biotium's next-generation fluorescent dyes. CF®488A is a green fluorescent dye (Ex/Em 490/515 nm) with excellent brightness and photostability. The dye is minimally charged for less non-specific binding. CF®488A also is compatible with super-resolution imaging by TIRF.
Catalog Number:
(75977-252)
Supplier:
Biotium
Description:
TOX3, Monoclonal antibody, Clone: TOX3/1123, Host: Mouse, Species reactivity: Human, Isotype: IgG1, kappa, BSA-free, Immunogen: Recombinant fragment (139 Amino acid residues around aa 200-400) of human TOX3 protein, Synonyms: TOX3, Application: IF, Size: 50 uL
Supplier:
Biotium
Description:
Chromogranin A is present in neuroendocrine cells throughout the body, including the neuroendocrine cells of the large and small intestine, adrenal medulla and pancreatic islets. It is an excellent marker for carcinoid tumors, pheochromocytomas, paragangliomas, and other neuroendocrine tumors. Co-expression of chromogranin A and neuron specific enolase (NSE) is common in neuroendocrine neoplasms. Reportedly, co-expression of certain keratins and chromogranin indicates neuroendocrine lineage. The presence of strong anti-chromogranin staining and absence of anti-keratin staining should raise the possibility of paraganglioma. The co-expression of chromogranin and NSE is typical of neuroendocrine neoplasms. Most pituitary adenomas and prolactinomas readily express chromogranin.
CF® dyes are Biotium's next-generation fluorescent dyes. CF®640R is a far-red fluorescent dye (Ex/Em 642/662 nm) with excellent brightness, and the best photostabiity among spectrally-similar dyes.
Supplier:
Biotium
Description:
This antibody recognizes an oncofetal glycoprotein with a single chain of 70 kDa, which is identified as alpha-fetoprotein (AFP) (ISOBM TD-2 workshop). This MAb is highly specific to AFP and shows no cross-reaction with other oncofetal antigens or serum albumin. AFP is normally synthesized in the liver, intestinal tract, and yolk sac of the fetus. Antibody to AFP has been shown to be useful in detecting hepatocellular carcinomas (HCC) and germ cell neoplasms, especially yolk sac tumors.
Catalog Number:
(89493-094)
Supplier:
Biotium
Description:
Anti-IgY Goat Polyclonal Antibody (CF™ 555)
Supplier:
Biotium
Description:
Cytokeratin 18 Monoclonal antibody, Clone: KRT18/1190, Host: Mouse, Species reactivity: Human, Rat, Isotype: IgG1, kappa, Conjugate: CF640R, Immunogen: Recom human KRT18 protein, Synonyms: K18, Application: IF, IHC, FC, Size: 100uL
Catalog Number:
(75915-964)
Supplier:
Biotium
Description:
Cytokeratin, LMW Monoclonal antibody, Clone: AE-1, Host: Mouse, Species reactivity: Mouse, Turtle, Monkey, Dog, Cow, Rat, Human, Chicken, Rabbit, Isotype: IgG1, K, Conjugate: BSA-free, Immunogen: Human epidermal keratin, Synonyms: K1B, Size: 50 uL
Supplier:
Biotium
Description:
Cytokeratin 17 Monoclonal antibody, Clone: E3, Host: Mouse, Species reactivity: Goat, Pig, Cow, Rat, Human, Isotype: IgG2b, kappa, Conjugate: CF568, Immunogen: The cytoskeletal fraction, Synonyms: K17, KRT17, PCHC1, Application: IF, IHC, IHC, Size: 500 uL
Supplier:
Biotium
Description:
This antibody recognizes a protein doublet of 20-22 kDa, identified as MART-1 (Melanoma Antigen Recognized by T cells 1) or Melan-A. MART-1 is a newly identified melanocyte differentiation antigen recognized by autologous cytotoxic T lymphocytes. Seven other melanoma associated antigens recognized by autologous cytotoxic T cells include MAGE-1, MAGE-3, tyrosinase, gp100, gp75, BAGE-1, and GAGE-1. Subcellular fractionation shows that MART-1 is present in melanosomes and endoplasmic reticulum. This MAb labels melanomas and other tumors showing melanocytic differentiation. It is also a useful positive-marker for angiomyolipomas. It does not stain tumor cells of epithelial, lymphoid, glial, or mesenchymal origin.
Supplier:
Biotium
Description:
Smooth Muscle Actin, Monoclonal antibody, Clone: ACTA2/791 +1A4, Host: Mouse, Species reactivity: Human, Rat, Isotype: IgG's, Conjugate: biotin, Immunogen: N-Terminal decapeptide of alpha smooth muscle isoform of actin & conjugated to KLH, Application: IF, Size: 500uL
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