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BIOTIUM, INC
Supplier:
Biotium
Description:
PTH (Parathyroid Hormone), Monoclonal antibody, Clone: 3H9 + PTH/1175, Host: Mouse, Species reactivity: Human, Isotype: IgG2a, kappa, Conjugate: CF594, Immunogen: Synthetic peptide corresponding to amino acids 1 to 34, Synonyms: hPTH; Parathormone, Application: IF, Size: 500uL
Supplier:
Biotium
Description:
PTH (Parathyroid Hormone), Monoclonal antibody, Clone: 3H9 + PTH/1175, Host: Mouse, Species reactivity: Human, Isotype: IgG2a, kappa, Conjugate: CF640R, Immunogen: Synthetic peptide corresponding to amino acids 1 to 34, Synonyms: hPTH; Parathormone, Application: IF, Size: 100uL
Supplier:
Biotium
Description:
S100 belongs to the family of calcium binding proteins. S100A and S100B proteins are two members of the S100 family. S100A is composed of an alpha and a beta chain whereas S100B is composed of two beta chains. This antibody is specific against an epitope located on the beta-chain (i.e. in S-100A and S-100B) but not on the alpha-chain of S-100 (i.e. in S-100A and S100A0). This antibody can be used to localize S-100A and S-100B in various tissue sections. S-100 protein has been found in normal melanocytes, Langerhans cells, histiocytes, chondrocytes, lipocytes, skeletal and cardiac muscle, Schwann cells, epithelial and myoepithelial cells of the breast, salivary and sweat glands, as well as in glial cells. Neoplasms derived from these cells also express S-100 protein, albeit non-uniformly. A large number of well-differentiated tumors of the salivary gland, adipose and cartilaginous tissue, and Schwann cell-derived tumors express S-100 protein. Almost all malignant melanomas and cases of histiocytosis X are positive for S-100 protein.
CF® dyes are Biotium's next-generation fluorescent dyes. CF®647 is a far-red fluorescent dye (Ex/Em 650/665 nm) with excellent brightness. It also is compatible with super-resolution imaging by STORM.
Supplier:
Biotium
Description:
In Western blotting, this antibody reacts with two bands of ~MW of 210 kDa and 300 kDa, identified as two isoforms of Tenascin C. Specificity of this MAb is validated by sequential immunoprecipitation with a PAb against Tenascin C. Tenascin C is a multifunctional, disulfide-linkedhexameric extracellular matrix glycoprotein expressed in association with mesenchymal epithelial interactions during development and in the neo-vasculature and stroma of undifferentiated tumors. In adults, it is restricted to certain epithelial-stromal interfaces and increases markedly in hyper-proliferative diseases and in stroma of many neoplasms, including gliomas, breast, squamous and lung carcinomas.
CF® dyes are Biotium's next-generation fluorescent dyes. CF®568 is a red fluorescent dye (Ex/Em 562/583 nm) with superior brightness and photostability. It also is compatible with super-resolution imaging by STORM and TIRF.
Supplier:
Biotium
Description:
TAG-72 / CA72.4, Monoclonal antibody, Clone: B72.3, Host: Mouse, Species reactivity: Human, Hamster, Dog, Cow, Rat, Isotype: IgG1, kappa, Conjugate: biotin, Immunogen: Membrane-enriched fraction of breast carcinoma, Synonyms: CA72.4, Size: 100uL
Supplier:
Biotium
Description:
TAG-72 / CA72.4, Monoclonal antibody, Clone: B72.3 + CC49, Host: Mouse, Species reactivity: Human, Hamster, Dog, Cow, Rat, Isotype: IgG1, kappa, Conjugate: biotin, Immunogen: Membrane-enriched fraction of a human breast, Synonym: CA72.4, Size: 100uL
Supplier:
Biotium
Description:
TAG-72 / CA72.4, Monoclonal antibody, Clone: B72.3 + CC49, Host: Mouse, Species reactivity: Human, Hamster, Dog, Cow, Rat, Isotype: IgG1, kappa, Conjugate: CF568, Immunogen: Membrane-enriched fraction of a human breast, Synonym: CA72.4, Size: 500uL
Supplier:
Biotium
Description:
This antibody reacts with the TGF alpha and shows no cross-reaction with EGF and the neuropeptide synenkephalin. The staining with this MAb is completely blocked by the peptide used for raising this antibody. TGF alpha (aa50) is a growth factor with 33% homology to EGF, binds to EGFR, activates tyrosine phosphorylation of the receptor, and stimulates cell proliferation. It plays a role in tumor initiation by inducing the reversible transformed phenotype.
CF® dyes are Biotium's next-generation fluorescent dyes. CF®640R is a far-red fluorescent dye (Ex/Em 642/662 nm) with excellent brightness, and the best photostabiity among spectrally-similar dyes.
Supplier:
Biotium
Description:
TGF-alpha, Monoclonal antibody, Clone: TGFA/1119, Host: Mouse, Species reactivity: Rabbit, Zebrafish, Human, Isotype: IgG1, kappa, Conjugate: CF568, Immunogen: A 10-amino acid synthetic peptide (aa34-43), Synonyms: EGF-like TGF; ETGF, Application: IF, Size: 100uL
Supplier:
Biotium
Description:
This antibody recognizes a 77-85 kDa protein, identified as cellular or tissue transglutaminase II (TGase II). Transglutaminases are enzymes that catalyze the crosslinking of proteins by epsilon-gamma glutamyl lysine isopeptide bonds. While the primary structure of transglutaminases is not conserved, they all have the same amino acid sequence at their active sites and their activity is calcium-dependent. The protein encoded by this gene acts as a monomer, is induced by retinoic acid, and appears to be involved in apoptosis. Finally, the encoded protein is the autoantigen implicated in celiac disease. The identification of transglutaminase as the main antigen of endomysium antibodies allows a new diagnostic approach to celiac disease (CD), a genetic, immunologically mediated small bowel enteropathy that causes malabsorption. TGase II is implicated in programmed cell death, signal transduction, drug-resistance, cell growth, endocytosis, insulin secretion, cell adhesion, cataract formation, and wound healing.
Supplier:
Biotium
Description:
IDH1, Monoclonal antibody, Clone: IDH1/1152, Host: Mouse, Species reactivity: Human, Isotype: IgG1 and IgG2a, kappa, Conjugate: CF405S, Immunogen: Recombinant fragment (119 Amino acid residues around aa 280-420) of human IDH1 protein, Application: IF, IHC (formalin), Size: 100uL
Supplier:
Biotium
Description:
This antibody recognizes a protein of 75 kDa, identified as γ heavy chain of human immunoglobulins. Its epitope maps in CH2 domain of Fc region of IgG. It reacts with all sub-classes of γ chain of human immunoglobulins. It does not cross-react with α (IgA), μ (IgM), ε (IgE), or δ (IgD), heavy chains, T-cells, monocytes, granulocytes, or erythrocytes. This MAb is useful in the identification of leukemias, plasmacytomas, and certain non-Hodgkins lymphomas. The most common feature of these malignancies is the restricted expression of a single heavy chain class. Demonstration of clonality in lymphoid infiltrates indicates that the infiltrate is clonal and therefore malignant.
CF® dyes are Biotium's next-generation fluorescent dyes. CF®405S is a blue fluorescent dye (Ex/Em 404/431 nm) with superior brightness compared to other blue dyes; it is also compatible with super-resolution imaging by SIM. Note: Conjugates of blue fluorescent dyes are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.
Supplier:
Biotium
Description:
IgM Immunoglobulin, Monoclonal antibody, Clone: IM260, Host: Mouse, Species reactivity: Human, Isotype: IgG1, kappa, Conjugate: purified, Immunogen: Heavy chain of human IgM, Synonyms: AGM1; IGHM, Application: IF, IHC (formalin), Flow, Size: 500uL
Supplier:
Biotium
Description:
WT1 (Wilm's Tumor 1), Monoclonal antibody, Clone: 6F-H2, Host: Mouse, Species reactivity: Mouse, Rat, Human, Isotype: IgG1, kappa, Conjugate: CF405S, Immunogen: Recombinant protein corresponding to residues 1-181 of human WT1, Synonyms: WT1; AWT1; FWT1, Size: 100uL
Supplier:
Biotium
Description:
WT1 (Wilm's Tumor 1), Monoclonal antibody, Clone: 6F-H2, Host: Mouse, Species reactivity: Mouse, Rat, Human, Isotype: IgG1, kappa, Conjugate: CF594, Immunogen: Recombinant protein corresponding to residues 1-181 of human WT1, Synonyms: WT1; AWT1; FWT1, Size: 500uL
Supplier:
Biotium
Description:
CD8 is a cell surface receptor expressed either as a heterodimer with the CD8 alpha chain (CD8 alpha/beta) or as a homodimer (CD8 alpha/alpha). A majority of thymocytes and a subpopulation of mature T cells and NK cell express CD8a. CD8 binds to MHC class 1 and through its association with protein tyrosine kinase p56lck plays a role in T cell development and activation of mature T cells. For mature T-cells, CD4 and CD8 are mutually exclusive, so anti-CD8, generally used in conjunction with anti-CD4. It is a useful marker for distinguishing helper/inducer T-lymphocytes, and most peripheral T-cell lymphomas are CD4 /CD8-. Anaplastic large cell lymphoma is usually CD4 and CD8-, and in T-lymphoblastic lymphoma/leukemia, CD4 and CD8 are often co-expressed. CD8 is also found in littoral cell angioma of the spleen.
CF® dyes are Biotium's next-generation fluorescent dyes. CF®640R is a far-red fluorescent dye (Ex/Em 642/662 nm) with excellent brightness, and the best photostabiity among spectrally-similar dyes.
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