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BIOTIUM, INC
Supplier:
Biotium
Description:
This antibody recognizes an epitope on the extracellular domain of gonadotropin releasing hormone (GnRH) receptor or luteinizing hormone receptor (LHCGR). Lutropin (also designated luteinizing hormone) plays a role in spermatogenesis and ovulation by stimulating the testes and ovaries to produce steroids. Gonadotropin (also designated choriogonadotropin) production in the placenta maintains estrogen and progesterone levels during the first trimester of pregnancy. Ovaries and testes abundantly express luteinizing hormone/choriogonadotropin receptor. GnRH receptor contains seven hydrophobic transmembrane domains connected by hydrophilic extracellular and intracellular loops characteristic of G-protein coupled receptors. GnRH stimulates the gonadotrophs of the anterior pituitary to secrete luteinizing hormone (LH) as well as follicle-stimulating hormone (FSH). GnRH influences the protective effect of pregnancy and Gonadotropin against breast cancer. The expression of GnRH on breast carcinoma correlates in part to the degree of tumor differentiation. GnRH-positive breast tumors occur more frequently in tumors with greater cell differentiation in premenopausal women. GnRH is present in luteal and granulosa cells as well as in ovarian cell membrane preparations.
CF® dyes are Biotium's next-generation fluorescent dyes. CF®640R is a far-red fluorescent dye (Ex/Em 642/662 nm) with excellent brightness, and the best photostabiity among spectrally-similar dyes.
Supplier:
Biotium
Description:
CD56 / NCAM Monoclonal antibody, Clone: 123C3.D5, Host: Mouse, Species reactivity: Human, Isotype: IgG1, kappa, Conjugate: CF405S, Immunogen: Membrane preparation of a small cell lung carcinoma, Synonyms: NCAM, Leu-19, NKH1, Size: 100uL
Catalog Number:
(75959-840)
Supplier:
Biotium
Description:
MART-1 / Melan-A, Monoclonal antibody, Clone: M2-9E3, Host: Mouse, Species reactivity: Mouse, Dog, Rat, Human, Isotype: IgG1, kappa, BSA-free, Immunogen: Recombinant hMART-1 protein, Synonyms: Antigen LB39-AA, Antigen SK29-AA, Application: IF, Size: 50 uL
Supplier:
Biotium
Description:
BCL-2 Monoclonal antibody, Clone: 100/D5 + 124, Host: Mouse, Species reactivity: Human, Isotype: IgG's, Conjugate: CF488A, Immunogen: A synthetic peptide, aa41-54 (GAAPAPGIFSSQPG-Cys), Synonyms: B-cell CLL/lymphoma-2, Application: IF, Western, FC, Size: 100uL
Supplier:
Biotium
Description:
This antibody reacts with tissue non-specific alkaline phosphatase. There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue non-specific). The first three are located together on chromosome 2, while the tissue non-specific form is located on chromosome 1. The product of this gene is a membrane bound glycosylated enzyme that is not expressed in any particular tissue and is, therefore, referred to as the tissue-nonspecific form of the enzyme. The exact physiological function of the alkaline phosphatases is not known. A proposed function of this form of the enzyme is matrix mineralization; however, mice that lack a functional form of this enzyme show normal skeletal development. This enzyme has been linked directly to hypo-phosphatasia, a disorder that is characterized by hypercalcemia and includes skeletal defects. The character of this disorder can vary, however, depending on the specific mutation since this determines age of onset and severity of symptoms. Alternatively spliced transcript variants, which encode the same protein, have been identified for this gene.
CF® dyes are Biotium's next-generation fluorescent dyes. CF®647 is a far-red fluorescent dye (Ex/Em 650/665 nm) with excellent brightness. It also is compatible with super-resolution imaging by STORM.
Supplier:
Biotium
Description:
Cyclin D1 Monoclonal antibody, Clone: DCS-6, Host: Mouse, Species reactivity: Mouse, Monkey, Rat, Human, Isotype: IgG2a, kappa, Conjugate: CF647, Immunogen: Human full length recombinant cyclin D1 protein, Application: IF, IHC, Western, FC, Size: 500 uL
Supplier:
Biotium
Description:
Cyclin B1 Monoclonal antibody, Clone: CCNB1/1098, Host: Mouse, Species reactivity: Mouse, Human, Isotype: IgG1, kappa, Conjugate: CF640R, Immunogen: Recom human full-length CCNB1 protein, Synonyms: CCNB, CCNB1, Application: IF, IHC, FC, Size: 100uL
Supplier:
Biotium
Description:
This antibody recognizes a single chain glycoprotein of 105/120 kDa, identified as CD30/Ki-1. CD30 is synthesized as a 90 kDa precursor, which is processed in the Golgi complex into a membrane-bound phosphorylated mature 105/120 kDa glycoprotein. In Hodgkins disease, CD30/Ki-1 antigen is expressed by mononuclear-Hodgkin and multinucleated Reed-Sternberg cells. It is also expressed by the tumor cells of a majority of anaplastic large cell lymphomas as well as by a varying proportion of activated T and B cells. This MAb distinguishes large cell lymphomas derived from activated lymphoid cells from histiocytic malignancies and lymphomas derived from resting and precursor lymphoid cells or from anaplastic carcinomas. About one third of the Ki-1 positive lymphomas lack the leukocyte common antigen (CD45).
Supplier:
Biotium
Description:
FOXP3 Monoclonal antibody, Clone: 3G3, Host: Mouse, Species reactivity: Mouse, Monkey, Human, Isotype: IgG1, kappa, Conjugate: CF488A, Immunogen: Full-length His-tagged mouse FOXP3 protein, Application: Immunofluorescence, Flow cytometry, Size: 100uL
Supplier:
Biotium
Description:
Involucrin, Monoclonal antibody, Clone: IVRN/827, Host: Mouse, Species reactivity: Human, Isotype: IgG1, kappa, Conjugate: CF568, Immunogen: Purified involucrin from human keratinocytes, Synonyms: IVL, Application: Immunofluorescence, Flow cytometry, Size: 500uL
Supplier:
Biotium
Description:
MART-1 / Melan-A, Monoclonal antibody, Clone: M2-9E3, Host: Mouse, Species reactivity: Mouse, Dog, Rat, Human, Isotype: IgG1, kappa, Conjugate: CF405S, Immunogen: Recombinant hMART-1 protein, Synonyms: Antigen LB39-AA, Application: IF, IHC Western, Size: 500uL
Supplier:
Biotium
Description:
EGFr Monoclonal antibody, Clone: GFR1195 + 31G7, Host: Mouse, Species reactivity: Human, Isotype: IgG1, kappa, Conjugate: biotin, Immunogen: Human EGFR purified from A431 cells ; Recom human EGFR protein, Synonyms: Erbb1, ERBB1, Application: IF, IHC, FC, Size: 100uL
Supplier:
Biotium
Description:
Expression of DOG-1 protein is elevated in the gastrointestinal stromal tumors (GISTs), c-kit signaling-driven mesenchymal tumors of the GI tract. DOG-1 is rarely expressed in other soft tissue tumors, which, due to appearance, may be difficult to diagnose. Immunoreactivity for DOG-1 has been reported in 97.8 percent of scorable GISTs, including all c-kit negative GISTs. Overexpression of DOG-1 has been suggested to aid in the identification of GISTs, including Platelet-Derived Growth Factor Receptor Alpha mutants that fail to express c-kit antigen. The overall sensitivity of DOG1 and c-kit in GISTs is nearly identical: 94.4% vs. 94.7%.
CF® dyes are Biotium's next-generation fluorescent dyes. CF®640R is a far-red fluorescent dye (Ex/Em 642/662 nm) with excellent brightness, and the best photostabiity among spectrally-similar dyes.
Supplier:
Biotium
Description:
PTH (Parathyroid Hormone), Monoclonal antibody, Clone: 3H9 + PTH/1175, Host: Mouse, Species reactivity: Human, Isotype: IgG2a, kappa, Conjugate: CF647, Immunogen: Synthetic peptide corresponding to amino acids 1 to 34, Synonyms: hPTH; Parathormone, Application: IF, Size: 100uL
Supplier:
Biotium
Description:
is prepared by labeling IgG with CF568, a red fluorescent dye with an excitation spectrum optimal for the 568nm laser line. Antibody conjugates of the dye are brighter & more photostable than those of Alexa Fluor 568 making CF568 a better choice for demanding applications.
Supplier:
Biotium
Description:
EGFr Monoclonal antibody, Clone: GFR1195, Host: Mouse, Species reactivity: Human, Isotype: IgG1, kappa, Conjugate: CF488A, Immunogen: Recom human EGFR protein, Synonyms: Erbb1, ERBB1, Errp, HER1, mENA, PIG61, Proto-oncogene c-ErbB-1, Application: IF, IHC, Size: 100uL
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 is still displayed and you need assistance, please call us at 1-800-932-5000.
Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the
is still displayed and you need assistance, please call us at 1-800-932-5000.
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