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BIOTIUM, INC
Supplier:
Biotium
Description:
MyoD1, Monoclonal antibody, Clone: 5.8A, Host: Mouse, Species reactivity: Mouse, Rat, Human, Chicken, Isotype: IgG1, kappa, Conjugate: CF647, Immunogen: Recombinant mouse MyoD1 protein, Synonyms: bHLHc1, Class C basic helix-loop-helix protein 1, Application: IF, Size: 500uL
Supplier:
Biotium
Description:
Nuclear Membrane, Monoclonal antibody, Clone: NM97, Host: Mouse, Species reactivity: Human, Isotype: IgM, kappa, Conjugate: CF647, Immunogen: Nuclei of myeloid leukemia biopsy cells, Application: Immunofluorescence, Size: 500uL
Supplier:
Biotium
Description:
Napsin-A, Monoclonal antibody, Clone: NAPSA/1238, Host: Mouse, Species reactivity: Human, Isotype: IgG's, Conjugate: CF568, Immunogen: Recombinant fragment of human Napsin-A protein, Synonyms: ASP4, Aspartyl protease 4, KAP, NAP1, NAPA, Application: IF, IHC, WB, Size: 500uL
Supplier:
Biotium
Description:
P21 / WAF1, Monoclonal antibody, Clone: WA-1, Host: Mouse, Species reactivity: Human, Isotype: IgG's, Conjugate: purified, Immunogen: Recombinant full-length human CDKN1A protein (CIP1/823); Human recombinant p21 protein (DCS-60.2), Application: IF, IHC, Size: 500uL
Supplier:
Biotium
Description:
This antibody recognizes a single protein of 33-34 kDa, identified as the prostate specific antigen (PSA). This MAb is highly specific to PSA and stains prostatic secretory and ductal epithelium in both normal and neoplastic tissues. PSA is a chymotrypsin-like serine protease (kallikrein family) exclusively produced by the prostate epithelium, and abundant in seminal fluid. PSA can be detected in the sera of patients with prostatic carcinoma. It is predominantly complexed to a liver-derived serine protease inhibitor, alpha-1-antichymotrypsin (ACT). A higher proportion of serum PSA is complexed to ACT in prostate cancer than in benign prostate hyperplasia. This MAb makes an excellent pair with MAb 1A7G6B6 for PSA tests.
CF® dyes are Biotium's next-generation fluorescent dyes. CF®568 is a red fluorescent dye (Ex/Em 562/583 nm) with superior brightness and photostability. It also is compatible with super-resolution imaging by STORM and TIRF.
Supplier:
Biotium
Description:
This antibody recognizes a 70 kDa membrane-bound isozyme (Regan and Nagao type) of Placental Alkaline Phosphatase (PLAP) occurring in the placenta during the 3rd trimester of gestation. It is highly specific for PLAP and shows no cross-reaction with other isozymes of alkaline phosphatase. Anti-PLAP This antibody recognizes germ cell tumors and can discriminate between these and other neoplasms. Somatic neoplasms e.g. breast, gastrointestinal, prostatic, and urinary cancers may also immunoreact with antibodies to PLAP. Anti-PLAP positivity in conjunction with anti-keratin negativity favors seminoma over carcinoma. Germ cell tumors are usually anti-keratin positive, but they regularly fail to stain with anti-EMA, whereas most carcinomas stain with anti-EMA. Anti-PLAP has been useful in the diagnosis of gestational trophoblastic disease.
Supplier:
Biotium
Description:
TAG-72 / CA72.4, Monoclonal antibody, Clone: CA72/145, Host: Mouse, Species reactivity: Human, Hamster, Dog, Cow, Rat, Isotype: IgG1, kappa, Conjugate: purified, Immunogen: Membrane-enriched fraction of a human breast, Synonym: CA72.4, Size: 500uL
Supplier:
Biotium
Description:
TAG-72 / CA72.4, Monoclonal antibody, Clone: B72.3 + CA72/733, Host: Mouse, Species reactivity: Human, Hamster, Dog, Cow, Rat, Isotype: IgG1, kappa, Conjugate: CF568, Immunogen: Membrane-enriched fraction of a human breast, Synonym: CA72.4, Size: 100uL
Supplier:
Biotium
Description:
TGF-alpha, Monoclonal antibody, Clone: TGFA/1119, Host: Mouse, Species reactivity: Rabbit, Zebrafish, Human, Isotype: IgG1, kappa, Conjugate: CF640R, Immunogen: A 10-amino acid synthetic peptide (aa34-43), Synonyms: EGF-like TGF; ETGF, Application: IF, Size: 100uL
Supplier:
Biotium
Description:
This MAb recognizes proteins of 19-22 kDa (reducing) and 38 kDa-44 kDa (non-reducing), identified as various isoforms of Vascular Endothelial Growth Factor or Vascular Permeability Factor (VEGF/VPF). It is highly specific to VEGF, which is a homodimeric, disulfide-linked glycoprotein with a close homology to platelet derived growth factor (PDGF). There are multiple isoforms of VEGF containing 206-, 189-, 165-, and 121-amino acid residues. The smaller two isoforms, VEGF165 and VEGF121, are secreted proteins and act as diffusible agents, whereas the larger two remain cell associated. VEGF/VPF plays an important role in angiogenesis, which promotes tumor progression and metastasis.
CF® dyes are Biotium's next-generation fluorescent dyes. CF®594 is a deep red fluorescent dye (Ex/Em 593/614 nm). It yields the brightest conjugates among spectrally similar dyes, and has excellent photostability.
Supplier:
Biotium
Description:
This MAb recognizes proteins of 19-22 kDa (reducing) and 38 kDa-44 kDa (non-reducing), identified as various isoforms of Vascular Endothelial Growth Factor or Vascular Permeability Factor (VEGF/VPF). It is highly specific to VEGF, which is a homodimeric, disulfide-linked glycoprotein with a close homology to platelet derived growth factor (PDGF). There are multiple isoforms of VEGF containing 206-, 189-, 165-, and 121-amino acid residues. The smaller two isoforms, VEGF165 and VEGF121, are secreted proteins and act as diffusible agents, whereas the larger two remain cell associated. VEGF/VPF plays an important role in angiogenesis, which promotes tumor progression and metastasis.
Supplier:
Biotium
Description:
WT1 (Wilm's Tumor 1), Monoclonal antibody, Clone: WT1/857, Host: Mouse, Species reactivity: Mouse, Rat, Human, Isotype: IgG1, kappa, Conjugate: CF568, Immunogen: Recombinant protein corresponding to residues 1-181 of human WT1, Synonyms: WT1; AWT1; FWT1, Size: 500uL
Supplier:
Biotium
Description:
WT1 (Wilm's Tumor 1), Monoclonal antibody, Clone: WT1/857, Host: Mouse, Species reactivity: Mouse, Rat, Human, Isotype: IgG1, kappa, Conjugate: CF647, Immunogen: Recombinant protein corresponding to residues 1-181 of human WT1, Synonyms: WT1; AWT1; FWT1, Size: 100uL
Supplier:
Biotium
Description:
Retinol Binding Protein-1, Monoclonal antibody, Clone: RBP1/872, Host: Mouse, Species reactivity: Goat, Chimpanzee, Monkey, Rat, Human, Rabbit, Isotype: IgG2a, kappa, Conjugate: CF488A, Immunogen: Retinol binding protein-1 purified from human plasma, Size: 100uL
Supplier:
Biotium
Description:
This antibody recognizes a protein of ~55 kDa, identified as SOX10. This MAb is highly specific and does not cross-react with other members of the SOX-family. SOX genes comprise a family of genes that are related to the mammalian sex-determining gene SRY. These genes similarly contain sequences that encode for the HMG-box domain, which is responsible for the sequence-specific DNA-binding activity. SOX-10 is a sensitive marker of melanoma, including conventional, spindled, and desmoplastic subtypes. It is expressed by metastatic melanomas and nodal capsular nevus in sentinel lymph nodes, but not by other lymph node components such as dendritic cells, which usually express S100 protein. Commonly used melanoma markers, such as anti-HMB-45 and anti-Melan-A, are poorly expressed in desmoplastic melanomas while SOX-10 is moderately to strongly expressed in desmoplastic melanomas. SOX-10 is considered as a very reliable marker for recognizing residual desmoplastic melanomas. In normal tissues, it is expressed in Schwann cells, melanocytes, and myoepithelial cells of salivary, bronchial and mammary glands. SOX-10 expression is also observed in mast cells.
CF® dyes are Biotium's next-generation fluorescent dyes. CF®568 is a red fluorescent dye (Ex/Em 562/583 nm) with superior brightness and photostability. It also is compatible with super-resolution imaging by STORM and TIRF.
Supplier:
Biotium
Description:
This MAb reacts with a membrane-associated protein present in normal and malignant neuroendocrine tissues including small cell lung cancer (SCLC). It stains neural and a variable number of endocrine tissues and in the lung it reacts preferentially with SCLC and carcinoids. Its epitope is destroyed during formalin fixation. This antibody was categorized during the First International Workshop on Small Cell Lung Cancer Antigens held in London in April 1987. There are two major types of Lung Carcinoma: non-small cell, which accounts for 80% of all cases; and small cell, which accounts for roughly 20% of all lung cancers reported. The lung continues to be a customary place for cancer migration from tumors elsewhere in the body. Treatment depends on the specific cell type of the cancer, level of progression and status of the individual patient.
CF® dyes are Biotium's next-generation fluorescent dyes. CF®594 is a deep red fluorescent dye (Ex/Em 593/614 nm). It yields the brightest conjugates among spectrally similar dyes, and has excellent photostability.
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