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BIOTIUM, INC
Supplier:
Biotium
Description:
c-Myc Monoclonal antibody, Clone: MYC275, Host: Mouse, Species reactivity: Human, Isotype: IgG1, kappa, Conjugate: CF594, Immunogen: Recombinant human c-myc protein, Application: IF, Immunohistology (formalin), FC, Size: 100uL
Supplier:
Biotium
Description:
MITF (microphthalmia transcription factor) is a basic helix-loop-helix-leucine-zipper (bHLH-Zip) transcription factor that regulates the development and survival of melanocytes and retinal pigment epithelium, and also is involved in transcription of pigmentation enzyme genes such as tyrosinase TRP1 and TRP2. MITF has been shown to be phosphorylated by MAP kinase in response to c-kit activation, resulting in upregulation of MITF transcriptional activity. Mutations of the MITF gene are associated with the autosomal dominant hereditary deafness and pigmentation condition, Waardenburg Syndrome type 2A. Multiple isoforms of MITF exist, including MITF-A, MITF-B, MITF-C, MITF-H, and MITF-M, which differ in the amino-terminal domain and in their expression patterns. The MITF-M isoform is restricted to the melanocyte cell lineage. This MAb recognizes a nuclear protein, which is expressed in the majority of primary and metastatic epithelioid malignant melanomas as well as in normal melanocytes, benign nevi and dysplastic nevi.
Supplier:
Biotium
Description:
This MAb recognizes a protein of 145 kDa, identified as CD117/p145kit. It is found on a wide variety of tumor cells including follicular and papillary carcinoma of thyroid, adenocarcinomas from endometrium, lung, ovary, pancreas, and breast as well as malignant melanoma, endodermal sinus tumor, and small cell carcinoma. However, anti-CD117 has been particularly useful in differentiating gastrointestinal stromal tumors from Kaposi's sarcoma, tumors of smooth muscle origin, fibromatosis, and neural tumors of the GI tract. Anti-CD117 is also useful in recognizing myeloblasts in bone marrow biopsy and clot section.
CF® dyes are Biotium's next-generation fluorescent dyes. CF®647 is a far-red fluorescent dye (Ex/Em 650/665 nm) with excellent brightness. It also is compatible with super-resolution imaging by STORM.
Supplier:
Biotium
Description:
Cytokeratin 8 Monoclonal antibody, Clone: H1 + TS1, Host: Mouse, Species reactivity: Human, Isotype: IgG2a, Conjugate: CF640R, Immunogen: Keratin preparation from a human carcinoma, Synonyms: CYK8, CYKER, Cytokeratin Endo A, Application: IF, Size: 100uL
Supplier:
Biotium
Description:
A highly selective actin filament stain for fixed and permeabilized cells. Labeled phalloidins have similar affinity for both large and small filaments.
Supplier:
Biotium
Description:
PLGF, Monoclonal antibody, Clone: PLGF94, Host: Mouse, Species reactivity: Human, Isotype: IgG1, kappa, Conjugate: CF488A, Immunogen: Recombinant human PLGF protein, Synonyms: PGFL; PIGF; placental growth factor (PGF), Application: ELISA, Size: 100uL
Supplier:
Biotium
Description:
CD43 Monoclonal antibody, Clone: SPN/839, Host: Mouse, Species reactivity: Human, Isotype: IgG1, kappa, Conjugate: purified, Immunogen: Recom full-length human SPN protein, Synonyms: GALGP, GPL115, Application: IF, IHC, WB, FC, Size: 500 uL
Supplier:
Biotium
Description:
Anti-IgG Donkey Polyclonal Antibody (CF™ 770)
Supplier:
Biotium
Description:
IgG Immunoglobulin, Monoclonal antibody, Clone: ICO-97, Host: Mouse, Species reactivity: Human, Isotype: IgG's, Conjugate: CF568, Immunogen: Purified polyclonal human Ig Gamma Chain, Application: Immunofluorescence, Immunohistology (formalin), Flow, Size: 500uL
Supplier:
Biotium
Description:
Anti-IgG Goat Polyclonal Antibody (CF™ 543)
Supplier:
Biotium
Description:
Ep-CAM / CD326 Monoclonal antibody, Clone: EGP40/837, Host: Mouse, Conjugate: CF568, Species reactivity: Human, Immunogen: Recombinant human TACSTD1 protein, Isotype: IgG1, Application: IF, FC, IHC, WB, Size: 100uL
Supplier:
Biotium
Description:
At least five CD1 genes (CD1a, b, c, d, and e) are identified. CD1 proteins have been demonstrated to restrict T cell response to non-peptide lipid and glycolipid antigens and play a role in non-classical antigen presentation. CD1a is a non-polymorphic MHC Class 1 related cell surface glycoprotein, expressed in association with Beta-2 microglobulin. Anti-CD1a labels Langerhans cell histiocytosis (Histiocytosis X), extranodal histiocytic sarcoma, a subset of T-lymphoblastic lymphoma/leukemia, and interdigitating dendritic cell sarcoma of the lymph node. When combined with antibodies against TTF-1 and CD5, anti-CD1a is useful in distinguishing between pulmonary and thymic neoplasms since CD1a is consistently expressed in thymic lymphocytes in both typical and atypical thymomas, but only focally in 1/6 of thymic carcinomas and not in lymphocytes in pulmonary neoplasms. Anti-CD1a is reported to be a new marker for perivascular epithelial cell tumor (PEComa).
CF® dyes are Biotium's next-generation fluorescent dyes. CF®647 is a far-red fluorescent dye (Ex/Em 650/665 nm) with excellent brightness. It also is compatible with super-resolution imaging by STORM.
Supplier:
Biotium
Description:
Smooth Muscle Actin, Monoclonal antibody, Clone: ACTA2/791 +1A4, Host: Mouse, Species reactivity: Human, Rat, Isotype: IgG's, Conjugate: CF640R, Immunogen: N-Terminal decapeptide of alpha smooth muscle isoform of actin & conjugated to KLH, Application: IF, Size: 500uL
Supplier:
Biotium
Description:
CMV-p65 Monoclonal antibody, Clone: CMV101, Host: Mouse, Species reactivity: CMV, Isotype: IgG1, kappa, Conjugate: CF405S, Immunogen: Recombinant CMV-p65 protein, Application: IF, Immunohistology (formalin), Immunohistology (frozen), Size: 100uL
Supplier:
Biotium
Description:
This antibody reacts with five invariable CD3 chains designated CD3y, CD3d, CD3e, CD3f, and CD3n with molecular weight ranging from 16-28 kDa. It is found on all mature T-lymphocytes, NK, T-cells, and some thymocytes. CD3, also known as T3, is a member of the immunoglobulin superfamily that plays a role in antigen recognition, signal transduction, and T cell activation. It is expressed, typically at high levels, on peripheral T cells and majority of T cell neoplasms. Thymocytes express CD3 at different level on the cell surface in the course of differentiation and, in cortical thymus, CD3 is predominantly intracytoplasmic. This MAb is particularly useful for induction of T cell activation in vitro and in vivo due to its unusual IgG3 isotype.
CF® dyes are Biotium's next-generation fluorescent dyes. CF®405S is a blue fluorescent dye (Ex/Em 404/431 nm) with superior brightness compared to other blue dyes; it is also compatible with super-resolution imaging by SIM. Note: Conjugates of blue fluorescent dyes are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.
Supplier:
Biotium
Description:
P21 / WAF1, Monoclonal antibody, Clone: DCS-60.2, Host: Mouse, Species reactivity: Human, Isotype: IgG's, Conjugate: biotin, Immunogen: Recombinant full-length human CDKN1A protein (CIP1/823); Human recombinant p21 protein (DCS-60.2), Application: IF, IHC, Size: 500uL
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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the
is still displayed and you need assistance, please call us at 1-800-932-5000.
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