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BIOTIUM, INC
Supplier:
Biotium
Description:
IgM Immunoglobulin, Monoclonal antibody, Clone: IM260 + ICO-30, Host: Mouse, Species reactivity: Human, Isotype: IgG1, kappa, Conjugate: CF594, Immunogen: Heavy chain of human IgM, Synonyms: AGM1; IGHM, Application: IF, IHC (formalin), Flow cytometry, Size: 100uL
Supplier:
Biotium
Description:
CD50 Monoclonal antibody, Clone: 101-1D2, Host: Mouse, Species reactivity: Human, Isotype: IgG2a, kappa, Conjugate: biotin, Immunogen: Stimulated human leukocytes, Synonyms: ICAMR, Intercellular adhesion molecule 3, Application: IF, Immunohistology, Size: 500 uL
Supplier:
Biotium
Description:
In Western blotting, this antibody recognizes proteins in MW range of 265-400 kDa, identified as different glycoforms of EMA. EMA may provide a protective layer on epithelial cells against bacterial and enzyme attack. In immunohistochemical assays, it superbly stains routine formalin/paraffin carcinomas. Antibody to EMA is useful as a pan-epithelial marker for detecting early metastatic loci of carcinoma in bone marrow or liver.
Supplier:
Biotium
Description:
This antibody recognizes a cluster of proteins between 70-80 kDa, identified as tyrosinase. Occasionally a minor band at 55 kDa is also detected. This MAb shows no cross-reaction with MAGE-1 and tyrosinase-related protein 1, TRP-1/gp75. Tyrosinase is a copper-containing metalloglycoprotein that catalyzes several steps in the melanin pigment biosynthetic pathway; the hydroxylation of tyrosine to L-3,4-dihydroxy-phenylalanine (dopa), and the subsequent oxidation of dopa to dopaquinone. Mutations of the tyrosinase gene occur in various forms of albinism. Tyrosinase is one of the targets for cytotoxic T-cell recognition in melanoma patients. Staining of melanomas with this MAb shows tyrosinase in melanotic as well as amelanotic variants. This MAb is a useful marker for melanocytes and melanomas.
Supplier:
Biotium
Description:
Chromogranin A is present in neuroendocrine cells throughout the body, including the neuroendocrine cells of the large and small intestine, adrenal medulla and pancreatic islets. It is an excellent marker for carcinoid tumors, pheochromocytomas, paragangliomas, and other neuroendocrine tumors. Co-expression of chromogranin A and neuron specific enolase (NSE) is common in neuroendocrine neoplasms. Reportedly, co-expression of certain keratins and chromogranin indicates neuroendocrine lineage. The presence of strong anti-chromogranin staining and absence of anti-keratin staining should raise the possibility of paraganglioma. The co-expression of chromogranin and NSE is typical of neuroendocrine neoplasms. Most pituitary adenomas and prolactinomas readily express chromogranin.
Supplier:
Biotium
Description:
P27 / KIP1, Monoclonal antibody, Clone: SX53G8), Host: Mouse, Species reactivity: Mouse, Monkey, Rat, Human, Isotype: IgG's, Conjugate: CF594, Immunogen: Mouse recombinant p27 protein (DCS-72.F6), Synonyms: CDKN1B, CDKN4, Cyclin Dependent Kinase Inhibitor 1B, Size: 100uL
Supplier:
Biotium
Description:
IgG Immunoglobulin, Monoclonal antibody, Clone: IG217, Host: Mouse, Species reactivity: Human, Isotype: IgG's, Conjugate: CF647, Immunogen: Purified polyclonal human Ig Gamma Chain, Application: Immunofluorescence, Immunohistology (formalin), Flow, Size: 500uL
Supplier:
Biotium
Description:
Mucin 5AC (MUC5AC), Monoclonal antibody, Clone: 45M1, Host: Mouse, Species reactivity: Mouse, Hedgehog, Monkey, Pig, Cat, Rat, Human, Chicken, Rabbit, Isotype: IgG1, kappa, Conjugate: biotin, Synonyms: Apomucin Major Airway Glycoprotein, Size: 500uL
Supplier:
Biotium
Description:
This antibody reacts with Ig domain of CD47 protein. CD47, originally named integrin-associated protein (IAP), is a 50 kDa protein containing five membrane-spanning sequences and a short cytoplasmic tail. CD47 plays a role in both cell adhesion by acting as an adhesion receptor for THBS1 on platelets, and in the modulation of integrins. It is important in memory formation and synaptic plasticity in the hippocampus. CD47 may play a role in membrane transport and/or integrin dependent signal transduction.
CF® dyes are Biotium's next-generation fluorescent dyes. CF®568 is a red fluorescent dye (Ex/Em 562/583 nm) with superior brightness and photostability. It also is compatible with super-resolution imaging by STORM and TIRF.
Supplier:
Biotium
Description:
VEGFR2 / Flk-1 / KDR3 / CD309, Monoclonal antibody, Clone: KDR657, Host: Mouse, Species reactivity: Human, Isotype: IgG1, kappa, Conjugate: CF405S, Immunogen: Recombinant human VEGF-R2 protein, Application: Immunofluorescence, Flow cytometry, Size: 500uL
Supplier:
Biotium
Description:
Involucrin, Monoclonal antibody, Clone: IVRN/827, Host: Mouse, Species reactivity: Human, Isotype: IgG1, kappa, Conjugate: CF488A, Immunogen: Purified involucrin from human keratinocytes, Synonyms: IVL, Application: Immunofluorescence, Flow cytometry, Size: 500uL
Supplier:
Biotium
Description:
Hepatocyte Specific Antigen, Monoclonal antibody, Clone: HSA133, Host: Mouse, Species reactivity: Human, Isotype: IgG2b, kappa, Conjugate: CF568, Immunogen: SK-H1A9-2 human hepatocellular carcinoma cells, Application: Immunofluorescence, Size: 500uL
Supplier:
Biotium
Description:
This antibody recognizes a protein of 25-26 kDa, identified as the bcl-2 α oncoprotein. It shows no cross-reaction with Bcl-x or Bax protein. Expression of bcl-2 α oncoprotein inhibits the programmed cell death (apoptosis). In most follicular lymphomas, neoplastic germinal centers express high levels of bcl-2 α protein, whereas the normal or hyperplastic germinal centers are negative. Consequently, this antibody is valuable when distinguishing between reactive and neoplastic follicular proliferation in lymph node biopsies. It may also be used in distinguishing between those follicular lymphomas that express bcl-2 protein and the small number in which the neoplastic cells are bcl-2 negative.
CF® dyes are Biotium's next-generation fluorescent dyes. CF®488A is a green fluorescent dye (Ex/Em 490/515 nm) with excellent brightness and photostability. The dye is minimally charged for less non-specific binding. CF®488A also is compatible with super-resolution imaging by TIRF.
Supplier:
Biotium
Description:
CD68 Monoclonal antibody, Clone: LAMP4/824, Host: Mouse, Species reactivity: Human, Isotype: IgG2a, kappa, Conjugate: purified, Immunogen: Recom human LAMP4 protein, Synonyms: GP110, LAMP4, Application: IF, IHC, FC, Size: 500 uL
Supplier:
Biotium
Description:
Glucose Regulated Protein 94 (GRP94), Monoclonal antibody, Clone: HSP90B1/1192, Host: Mouse, Species reactivity: Horse, Monkey, Pig, Dog, Cow, Sheep, Rat, Human, Guinea Pig, Isotype: IgM, kappa, Conjugate: CF488A, Immunogen: Purified (grp94), Size: 100uL
Catalog Number:
(75885-508)
Supplier:
Biotium
Description:
Calponin-1 Monoclonal antibody, Clone: CALP + CNN1/832, Host: Mouse, Species reactivity: Human, Rat, Isotype: IgG1, K, Conjugate: BSA-free, Immunogen: Recom full-length human CNN1 ; Crude human uterus extract, Synonyms: CNN1, Cnn1, Application: IF, Size: 50 uL
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