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BIOTIUM, INC
Catalog Number:
(75918-674)
Supplier:
Biotium
Description:
This MAb recognizes protein of 26 kDa-60 kDa, which is identified as CD63. Its epitope is different from that of MAb LAMP3/529. The tetraspanins are integral membrane proteins expressed on cell surface and granular membranes of hematopoietic cells and are components of multi-molecular complexes with specific integrins. The tetraspanin CD63 is a lysosomal membrane glycoprotein that translocates to the plasma membrane after platelet activation. CD63 is expressed on activated platelets, monocytes and macrophages, and is weakly expressed on granulocytes, T cell and B cells. It is located on the basophilic granule membranes and on the plasma membranes of lymphocytes and granulocytes. CD63 is a member of the TM4 superfamily of leukocyte glycoproteins that includes CD9, CD37 and CD53, which contain four transmembrane regions. CD63 may play a role in phagocytic and intracellular lysosome-phagosome fusion events. CD63 deficiency is associated with Hermansky-Pudlak syndrome and is strongly expressed during the early stages of melanoma progression.
Supplier:
Biotium
Description:
FOXP3 Monoclonal antibody, Clone: FXP3/197, Host: Mouse, Species reactivity: Mouse, Monkey, Human, Isotype: IgG1, kappa, Conjugate: CF568, Immunogen: Recombinant human full-length FOXP3 protein, Application: IF, Immunohistology, Size: 500 uL
Supplier:
Biotium
Description:
Cyclin A2 Monoclonal antibody, Clone: E67, Host: Mouse, Species reactivity: Mouse, Mink, Green monkey, Monkey, Cow, Human, Isotype: IgG1, kappa, Conjugate: CF568, Immunogen: Full length bovine Cyclin A, Synonyms: CCN1, CCNA, CCNA2, Application: IF, Size: 100uL
Supplier:
Biotium
Description:
Complement C4d Monoclonal antibody, Clone: TDM16, Host: Mouse, Species reactivity: Human, Isotype: IgG1, kappa, Conjugate: CF405S, Immunogen: Human Complement 4d protein, Application: Immunofluorescence, Flow cytometry, Size: 500 uL
Supplier:
Biotium
Description:
Cytokeratin 8/18 Monoclonal antibody, Clone: C-43 + DC10, Host: Mouse, Species reactivity: Human, Isotype: IgG1, K, Conjugate: CF405S, Immunogen: Cytoskeletal preparation from HeLa epitheliod carcinoma cells and PMC-42 breast carcinoma cells, Size: 100uL
Supplier:
Biotium
Description:
The c-Myc protein is a transcription factor, which is encoded by the c-Myc gene on human chromosome 8q24. c-Myc is commonly activated in a variety of tumor cells and plays an important role in cellular proliferation, differentiation, apoptosis and cell cycle progression. The phosphorylation of c-Myc has been investigated and previous studies have suggested a functional association between phosphorylation at Thr58/Ser62 by glycogen synthase kinase 3, cyclin dependent kinase, ERK2 and C-Jun N terminal Kinase (JNK) in cell proliferation and cell cycle regulation. Studies also have shown that c-Myc is essential for tumor cell development in vasculogenesis and angiogenesis that distribute blood throughout the cells, and which brought extensive attention in the development of new therapeutic approach for cancer treatment.
CF® dyes are Biotium's next-generation fluorescent dyes. CF®594 is a deep red fluorescent dye (Ex/Em 593/614 nm). It yields the brightest conjugates among spectrally similar dyes, and has excellent photostability.
Supplier:
Biotium
Description:
Creatine Phosphokinase Monoclonal antibody, Clone: 2ba6, Host: Mouse, Species reactivity: Human, Isotype: IgG1, kappa, Conjugate: purified, Immunogen: Human CKBB protein, Application: IF, Immunohistology (frozen), FC, Size: 500 uL
Supplier:
Biotium
Description:
Cytokeratin 19 Monoclonal antibody, Clone: A53-B/A2 + BA17, Host: Mouse, Species reactivity: Human, Isotype: IgG's, Conjugate: CF405S, Immunogen: Human breast cancer MCF-7 cells, Synonyms: k19, k1cs, krt19, Application: IF, Size: 100uL
Catalog Number:
(75784-038)
Supplier:
Biotium
Description:
SUMO-1, Monoclonal antibody, Clone: SUMO1/1188, Host: Mouse, Species reactivity: Human, Rat, Isotype: IgG1, kappa, Conjugate: CF594, Immunogen: Recombinant human SUMO1 protein, Application: Immunofluorescence, Immunohistology (formalin), Western, Flow cytometry, Size: 500uL
Supplier:
Biotium
Description:
Thyroglobulin is a 660 kDa dimeric pre-protein with mutiple glycosylation sites. It is produced by and processed within the thyroid gland to produce the hormone thyroxine and triiodothyronine. Prior to forming dimers, thyroglobulin monomers undergo conformational maturation in the endoplasmic reticulation. The vast majority of follicular carcinomas of the thyroid will give positive immunoreactivity for anti-thyroglobulin even though sometimes only focally. Poorly differentiated carcinomas of the thyroid are frequently anti-thyroglobulin negative. Adenocarcinomas of other-than-thyroid origin do not react with this antibody. This antibody is useful in identification of thyroid carcinoma of the papillary and follicular types. Presence of thyroglobulin in metastatic lesions establishes the thyroid origin of tumor. Anti-thyroglobulin, combined with anti-calcitonin, can identify medullary carcinomas of the thyroid. Furthermore, anti-thyroglobulin, combined with anti-TTF1, can be a reliable marker to differentiate between primary thyroid and lung neoplasms.
CF® dyes are Biotium's next-generation fluorescent dyes. CF®488A is a green fluorescent dye (Ex/Em 490/515 nm) with excellent brightness and photostability. The dye is minimally charged for less non-specific binding. CF®488A also is compatible with super-resolution imaging by TIRF.
Supplier:
Biotium
Description:
This antibody recognizes a protein of ~55 kDa, identified as SOX10. This MAb is highly specific and does not cross-react with other members of the SOX-family. SOX genes comprise a family of genes that are related to the mammalian sex-determining gene SRY. These genes similarly contain sequences that encode for the HMG-box domain, which is responsible for the sequence-specific DNA-binding activity. SOX-10 is a sensitive marker of melanoma, including conventional, spindled, and desmoplastic subtypes. It is expressed by metastatic melanomas and nodal capsular nevus in sentinel lymph nodes, but not by other lymph node components such as dendritic cells, which usually express S100 protein. Commonly used melanoma markers, such as anti-HMB-45 and anti-Melan-A, are poorly expressed in desmoplastic melanomas while SOX-10 is moderately to strongly expressed in desmoplastic melanomas. SOX-10 is considered as a very reliable marker for recognizing residual desmoplastic melanomas. In normal tissues, it is expressed in Schwann cells, melanocytes, and myoepithelial cells of salivary, bronchial and mammary glands. SOX-10 expression is also observed in mast cells.
CF® dyes are Biotium's next-generation fluorescent dyes. CF®647 is a far-red fluorescent dye (Ex/Em 650/665 nm) with excellent brightness. It also is compatible with super-resolution imaging by STORM.
Supplier:
Biotium
Description:
TRAcP (Tartarate Resistant Acid Phosphatase), Monoclonal antibody, Clone: ACP5/1070, Host: Mouse, Species reactivity: Mouse, Rat, Human, Isotype: IgG2b, kappa, Conjugate: biotin, Immunogen: Recombinant full-length human ACP5 protein, Application: IF, Flow cytometry, Size: 500uL
Supplier:
Biotium
Description:
CD21 Monoclonal antibody, Clone: FR5A10, Host: Mouse, Species reactivity: Human, Isotype: IgG3, kappa, Conjugate: biotin, Immunogen: Raji cells, Synonyms: CD21, Complement C3d receptor (C3DR), Application: IF, IHC, FC, Size: 500 uL
Supplier:
Biotium
Description:
MHC II (HLA-DRA), Monoclonal antibody, Clone: IPO-10, Host: Mouse, Species reactivity: Human, Monkey, Isotype: IgM, kappa, Conjugate: CF568, Immunogen: Spleen cells of a patient with hairy cell leukemia (Daudi cells), Application: Immunofluorescence, Flow, Size: 500uL
Supplier:
Biotium
Description:
This antibody recognizes a protein of 52 kDa-58 kDa, identified as CD46 (also known as membrane cofactor protein, MCP). Its epitope is located on the four immunogenic short consensus repeat (SCR) domains at N-terminus of the protein. CD46 exists as many isoforms in a variety of tissues. It is strongly expressed on salivary gland ducts and kidney ducts, moderately on lymphocytes and endothelium, and weakly on interstitial tissues and muscle cells, but not on erythrocytes. CD46 functions as a C3b/C4b-binding glycoprotein that inhibits complement activation on host cells. It also serves as a measles virus receptor, an adherence factor for group A Streptococcus pyogenes, and a cellular pilus receptor for pathogenic Neisseria.
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